Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Ilya N, Shindyalov BPE (2000) The protein data bank. Nucleic Acids Res 28:235–242. https://doi.org/10.1093/nar/28.1.235
Article PubMed PubMed Central CAS Google Scholar
Bonfili L, Amici M, Cecarini V, Cuccioloni M, Tacconi R, Angeletti M, Eleuteri AM (2009) Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation. Biochimie 91:1131–1144. https://doi.org/10.1016/j.biochi.2009.06.001
Article PubMed CAS Google Scholar
Brown ED, Wright GD (2016) Antibacterial drug discovery in the resistance era. Nature 529:336–343. https://doi.org/10.1038/nature17042
Article PubMed CAS Google Scholar
Castaño G, Más R, Fernández JC, Fernández L, Illnait J, López E (2002) Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs RD 3:159–172. https://doi.org/10.2165/00126839-200203030-00004
Ciric MZ, Ostojic M, Baralic I, Kotur-Stevuljevic J, Djordjevic BI, Markovic S, Stankovic I (2021) Supplementation with octacosanol affects the level of PCSK9 and restore its physiologic relation with LDL-C in patients on chronic statin therapy. Nutrients 13:903. https://doi.org/10.3390/nu13030903
Article PubMed PubMed Central CAS Google Scholar
Ciric MZ, Kotur-Stevuljevic J, Stankovic I, Djordjevic B, Baralic I, Ostojic M (2023) Association of octacosanol supplementation with redox status in patients on chronic statin therapy. J Med Biochem 42:47–57. https://doi.org/10.5937/jomb0-38224
Cunningham D, Danley DE, Geoghegan KF, Griffor MC, Hawkins JL, Subashi TA, Varghese AH, Ammirati MJ, Culp JS, Hoth LR, Mansour MN, McGrath KM, Seddon AP, Shenolikar S, Stutzman-Engwall KJ, Warren LC, Xia D, Qiu X (2007) Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat Struct Mol Biol 14:413–419. https://doi.org/10.1038/nsmb1235
Article PubMed CAS Google Scholar
de Oliveira AM, Conserva LM, de Souza Ferro JN, de Almeida BF, Lyra Lemos RP, Barreto E (2012) Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. Int J Mol Sci 13:1598–1611. https://doi.org/10.3390/ijms13021598
Article PubMed PubMed Central CAS Google Scholar
Dewalkar LP, Shambharkar RB, Masram SC (2014) Immunostimulatory effects of etiolated wheatgrass, Triticum aestivum L. on dexamethasone induced immunosuppressed albino rats. J Pharm Sci 6:556–558
Fährrolfes R, Bietz S, Flachsenberg F, Meyder A, Nittinger E, Otto T, Rarey M (2017) Proteins Plus: a web portal for structure analysis of macromolecules. Nucleic Acids Res 45:337–343. https://doi.org/10.1093/nar/gkx333
Francini-Pesenti FD, Beltramolli S, Dall’Acqua BF (2008) Effect of sugar cane policosanol on lipid profile in primary hypercholesterolemia. Phytother Res 22:318–322. https://doi.org/10.1002/ptr.2315
Article PubMed CAS Google Scholar
Hernández F, Illnait J, Más R, Castaño G, Fernández L, Gonzalez M (1992) Effect of policosanol on serum lipids and lipoproteins in healthy volunteers. Curr Ther Res 51:568–575
Hooper AJ, Watts GF (2015) Sorting the wheat from the chaff in familial hypercholesterolemia. Clin Chem 61:6–8. https://doi.org/10.1373/clinchem.2014.234609
Article PubMed CAS Google Scholar
Horton JD, Cohen JC, Hobbs HH (2007) Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem Sci 32:71–77. https://doi.org/10.1016/j.tibs.2006.12.008
Article PubMed PubMed Central CAS Google Scholar
Kamboj VP (2000) Herbal medicine. Curr Sci 78:35–39
Kellenberger E, Muller P, Schalon C, Bret G, Foata N, Rognan D (2006) sc-PDB: an annotated database of druggable binding sites from the Protein Data Bank. J Chem Inf Model 46:717–727. https://doi.org/10.1021/ci050372x
Article PubMed CAS Google Scholar
Keskes H, Belhadj S, Jlail L, El Feki A, Damak M, Sayadi S, Allouche N (2017) LC-MS–MS and GC-MS analyses of biologically active extracts and fractions from Tunisian Juniperus phoenice leaves. Pharm Biol 55:88–95. https://doi.org/10.1080/13880209.2016.1230139
Article PubMed CAS Google Scholar
Kitts DD, Kopec A, Zawistowski J, Popovich DG (2012) Effects of high molecular weight alcohols from sugar cane fed alone or in combination with plant sterols on lipid profile and antioxidant status of Wistar rats. Appl Physiol Nutr Metab 37:938–946. https://doi.org/10.1139/h2012-072
Article PubMed CAS Google Scholar
Laskowski RA, Swindells MB (2011) LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model 51:2778–2786. https://doi.org/10.1021/ci200227u
Article PubMed CAS Google Scholar
Malongane F, McGAW LJ, Mudau FN (2017) The synergistic potential of various teas, herbs and therapeutic drugs in health improvement: a review. J Sci Food Agric 97:4679–4689. https://doi.org/10.1002/jsfa.8472
Article PubMed CAS Google Scholar
Nayak S, Bhat MP, Udayashankar AC, Lakshmeesha TR, Geetha N, Jogaiah S (2020) Biosynthesis and characterization of Dillenia indica-mediated silver nanoparticles and their biological activity. Appl Organomet Chem 34:5567. https://doi.org/10.1002/aoc.5567
O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR (2011) Open Babel: an open chemical toolbox. J Cheminformatics 3(1):1–14. https://doi.org/10.1186/1758-2946-3-33
Ohashi K, Ishikawa H, Ohta Y (2011) Octacosanol ameliorates hyperlipidemia and oxidative stress in KKAy mice with type 2 diabetes. J Anal Bio-Sci 34(3):1598–1611
Ouyang M, Li C, Hu D, Peng D, Yu B (2023) Mechanisms of unusual response to lipid-lowering therapy: PCSK9 inhibition. Clin Chim Acta 538:113–123. https://doi.org/10.1016/j.cca.2022.11.018
Article PubMed CAS Google Scholar
Pandey MM, Rastogi S, Rawat AK (2013) Indian traditional ayurvedic system of medicine and nutritional supplementation. Evid Based Complem Altern Med 2013:376327. https://doi.org/10.1155/2013/376327
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25:1605–1612. https://doi.org/10.1002/jcc.20084
Article PubMed CAS Google Scholar
Piper DE, Jackson S, Liu Q, Romanow WG, Shetterly S, Thibault ST, Shan B, Walker NP (2007) The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol. Structure 15(5):545–552. https://doi.org/10.1016/j.str.2007.04.004
Article PubMed CAS Google Scholar
Razack S, Hemanth Kumar K, Nallamuthu I, Naika M, Khanum F (2015) Antioxidant, biomolecule oxidation protective activities of Nardostachys jatamansi DC and its phytochemical analysis by RP-HPLC and GC-MS. Antioxidants 4:185–203. https://doi.org/10.3390/antiox4010185
Article PubMed PubMed Central CAS Google Scholar
Sanner MF (1999) Python: a programming language for software integration and development. J Mol Graph Model 17:57–61
Sarkar A, Kellogg GE (2010) Hydrophobicity-shake flasks, protein folding and drug discovery. Curr Top Med Chem 10:67–83. https://doi.org/10.2174/156802610790232233
Article PubMed PubMed Central CAS Google Scholar
Schöning-Stierand K, Diedrich K, Fährrolfes R, Flachsenberg F, Meyder A, Nittinger E, Rarey M (2020) Proteins Plus: interactive analysis of protein–ligand binding interfaces. Nucleic Acids Res 48:48–53. https://doi.org/10.1093/nar/gkaa235
Comments (0)