Bao Yuqing, Jinzhou Medical University
Peng Chengyu, Jinzhou Medical University
Zhang Fenglei, Stem Cell Center of Precision Medicine Innovation Institute, He University
Zheng Yuqiang, Stem Cell Center of Precision Medicine Innovation Institute, He University
Zhang Mingqi, Department of Stem Cell Center of Precision Medicine Innovation Institute, He University, No.66 Sishui Street, Hunnan District, Shenyang, 110163, ChinaFollow
He Wei, Department of Stem Cell Center of Precision Medicine Innovation Institute, He University, No.66 Sishui Street, Hunnan District, Shenyang, 110163, China.Follow

Corneal epithelial cells, Protocorm-like bodies of Dendrobium officinale, Dry eye disease, Inflammation, Nanovesicles

Plant-derived nanovesicles (PDNVs) offer a promising, biocompatible therapeutic platform. In this study, we isolatednanovesicles from protocorm-like bodies of Dendrobium officinale (PLBs-NVs) and evaluated their efficacy in dry eyedisease (DED) models. PLBs-NVs protected human corneal epithelial cells against hyperosmotic stress, supportedwound repair, and inhibited inflammation in vitro. In a desiccating stress-induced DED mouse model, topical PLBs-NVstreatment significantly restored tear secretion, reduced corneal epithelial damage, and lowered levels of proinflammatorycytokines. These results suggest that PLBs-NVs are a safe, natural, and effective therapeutic strategy for DED, sup-porting their potential for future clinical translation in ocular surface disorders.

Yuqing, Bao; Chengyu, Peng; Fenglei, Zhang; Yuqiang, Zheng; Mingqi, Zhang; and Wei, He (2025) "Nanovesicles derived from protocorm-like bodies of Dendrobium officinal enhance corneal epithelial repair and reduce inflammation in dry eye disease models," Journal of Food and Drug Analysis: Vol. 33 : Iss. 3 , Article 10.
Available at: https://doi.org/10.38212/2224-6614.3559

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