Jashanpreet Kaur, Department of pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111,Follow
Gursimran Kaur, Department of pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111
Chamanpreet Kaur, Department of pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111,
Sandeep Kumar, Department of pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, PIN: 140111,

Drug delivery, Endothelial cells, Nanosponges, Pulmonary hypertension, Targeted therapy

Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side effects andimproving drug efficacy. Additionally, their unique surface properties allow for targeted delivery to specific cells or tissues involved in PH, such as the pulmonary arteries' smooth muscle and endothelial cells. This review explores the potential role of nanosponges in pulmonary hypertension, highlighting recent advances in their design and function-alization. The integration of nanosponges into PH therapy could revolutionize the treatment landscape, offering more effective and individualized treatment plans.

Kaur, Jashanpreet; Kaur, Gursimran; Kaur, Chamanpreet; and Kumar, Sandeep (2025) "Targeted nanosponge-based treatment for pulmonary hypertension: A novel approach," Journal of Food and Drug Analysis: Vol. 33 : Iss. 3 , Article 3.
Available at: https://doi.org/10.38212/2224-6614.3550

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