Seok Hyun Chung, Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Republic of Korea
Hyeongyeong Kim, Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Republic of Korea
Singeun Kim, Life Science Research Institute, NOVAREX Co., Ltd., Cheongju 28220, Republic of Korea
Pan-Young Jeong, Life Science Research Institute, NOVAREX Co., Ltd., Cheongju 28220, Republic of Korea
Hyowon Lee, Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Republic of KoreaFollow

Antioxidant, GABA receptors, Neuroprotection, Oxidative stress, Sleep

Jujube seed extract (JSE), rich in polyphenols and flavonoids, exhibits neuroprotective and sleep-enhancing properties.In vitro, JSE protected HT22 cells against oxidative stress by activating the Nrf2/HO-1 pathway and upregulatingantioxidant enzymes. In vivo, JSE increased non-REM sleep and delta wave activity in pentobarbital- and caffeine-induced sleep models. Spinosin contributed to these effects. Long-term JSE administration upregulated GABAA, GABAB, and 5-HT1A receptors in brain tissue. These findings suggest that JSE offers dual benefits in mitigating oxidativestress and promoting sleep through antioxidant defense and neurotransmitter modulation, supporting its potential as a natural therapeutic agent.

Chung, Seok Hyun; Kim, Hyeongyeong; Kim, Singeun; Jeong, Pan-Young; and Lee, Hyowon (2025) "Protective effects of jujube seed extract against oxidative stress in HT22 cells and its sleep-promoting action through GABAergic receptors," Journal of Food and Drug Analysis: Vol. 33 : Iss. 3 , Article 8.
Available at: https://doi.org/10.38212/2224-6614.3555

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