Abdullah A, Zhang M, Frugier T, Bedoui S, Taylor JM, Crack PJ (2018) STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury. J Neuroinflammation 15(1):323
Article CAS PubMed Central PubMed Google Scholar
Abe T, Barber GN (2014) Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-kappaB activation through TBK1. J Virol 88(10):5328–5341
Article PubMed Central PubMed Google Scholar
Aguado J, Chaggar HK, Gomez-Inclan C, Shaker MR, Leeson HC, Mackay-Sim A, Wolvetang EJ (2021) Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids. Aging Cell 20(9):e13468
Article CAS PubMed Central PubMed Google Scholar
Bähr O, Gross S, Harter PN, Kirches E, Mawrin C, Steinbach JP, Mittelbronn M (2017) ASA404, a vascular disrupting agent, as an experimental treatment approach for brain tumors. Oncol Lett 14(5):5443–5451
PubMed Central PubMed Google Scholar
Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC (2018) Chromosomal instability drives metastasis through a cytosolic DNA response. Nature 553(7689):467–472
Article CAS PubMed Central PubMed Google Scholar
Bao P, Gu HY, Ye JJ, He JL, Zhong Z, Yu AX, Zhang XZ (2024) Chimeric exosomes functionalized with STING activation for personalized glioblastoma immunotherapy. Adv Sci (Weinh) 11(6):e2306336
Barrett JP, Knoblach SM, Bhattacharya S, Gordish-Dressman H, Stoica BA, Loane DJ (2021) Traumatic brain injury induces cGAS activation and type I interferon signaling in aged mice. Front Immunol 12:710608
Article CAS PubMed Central PubMed Google Scholar
Bielecki PA, Lorkowski ME, Becicka WM, Atukorale PU, Moon TJ, Zhang Y, Wiese M, Covarrubias G, Ravichandran S, Karathanasis E (2021) Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors. Nanoscale Horiz 6(2):156–167
Article CAS PubMed Central PubMed Google Scholar
Bodda C, Reinert LS, Fruhwurth S, Richardo T, Sun C, Zhang BC, Kalamvoki M, Pohlmann A, Mogensen TH, Bergstrom P, Agholme L, O’Hare P, Sodeik B, Gyrd-Hansen M, Zetterberg H, Paludan SR (2020) HSV1 VP1–2 deubiquitinates STING to block type I interferon expression and promote brain infection. J Exp Med. https://doi.org/10.1084/jem.20191422
Article PubMed Central PubMed Google Scholar
Boudreau CE, Najem H, Ott M, Horbinski C, Fang D, DeRay CM, Levine JM, Curran MA, Heimberger AB (2021) Intratumoral delivery of STING agonist results in clinical responses in canine glioblastoma. Clin Cancer Res 27(20):5528–5535
Article CAS PubMed Central PubMed Google Scholar
Cao Y, Shi M, Liu L, Zuo Y, Jia H, Min X, Liu X, Chen Z, Zhou Y, Li S, Yang G, Liu X, Deng Q, Chen F, Chen X, Zhang S, Zhang J (2023) Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1alpha pathway after traumatic brain injury in mice. Front Immunol 14:1125759
Article CAS PubMed Central PubMed Google Scholar
Ceron S, North BJ, Taylor SA, Leib DA (2019) The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease. Virology 529:23–28
Article CAS PubMed Google Scholar
Chang H, Li Z, Zhang W, Lin C, Shen Y, Zhang G, Mao L, Ma C, Liu N, Lu H (2024) Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage. Cell Commun Signal 22(1):3
Article CAS PubMed Central PubMed Google Scholar
Chellen T, Bausart M, Maus P, Vanvarenberg K, Limaye N, Preat V, Malfanti A (2024) In situ administration of STING-activating hyaluronic acid conjugate primes anti-glioblastoma immune response. Mater Today Bio 26:101057
Article CAS PubMed Central PubMed Google Scholar
Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, Jacob L, Patwa R, Shah H, Xu K, Cross JR, Massagué J (2016) Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533(7604):493–498
Article CAS PubMed Central PubMed Google Scholar
Chen Q, Boire A, Jin X, Valiente M, Emrah Er E, Lopez-Soto A, Jacob LS, Patwa R, Shah H, Xu K, Cross JR, Massagué J (2017) Corrigendum: carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 544(7648):124
Article CAS PubMed Google Scholar
Chen X, Yu M, Xu W, Kun P, Wan W, Yuhong X, Ye J, Liu Y, Luo J (2022) PCBP2 reduced oxidative stress-induced apoptosis in glioma through cGAS/STING pathway by METTL3-mediated m6A modification. Oxid Med Cell Longev 2022:9049571
Article PubMed Central PubMed Google Scholar
Chen J, Zhu T, Yu D, Yan B, Zhang Y, Jin J, Yang Z, Zhang B, Hao X, Chen Z, Yan C, Yu J (2023) Moderate intensity of treadmill exercise rescues TBI-induced ferroptosis, neurodegeneration, and cognitive impairments via suppressing STING pathway. Mol Neurobiol. https://doi.org/10.1007/s12035-023-03379-8
Article PubMed Central PubMed Google Scholar
Chen Y, Tian H, Zhang X, Nice EC, Huang C, Zhang H, Zheng S (2024) Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming. J Nanobiotechnol 22(1):801
Cherney EC, Zhang L, Lo J, Huynh T, Wei D, Ahuja V, Quesnelle C, Schieven GL, Futran A, Locke GA, Lin Z, Monereau L, Chaudhry C, Blum J, Li S, Fereshteh M, Li-Wang B, Gangwar S, Pan C, Chong C, Zhu X, Posy SL, Sack JS, Zhang P, Ruzanov M, Harner M, Akhtar F, Schroeder GM, Vite G, Fink B (2022) Discovery of non-nucleotide small-molecule STING agonists via chemotype hybridization. J Med Chem 65(4):3518–3538
Article CAS PubMed Google Scholar
Chiu LY, Sun Q, Zenke FT, Blaukat A, Vassilev LT (2023) Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death. Aging (Albany NY) 15(2):492–512
Article CAS PubMed Google Scholar
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N (2021) Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C. Nature 596(7873):570–575
Article CAS PubMed Central PubMed Google Scholar
Chung S, Jeong JH, Park JC, Han JW, Lee Y, Kim JI, Mook-Jung I (2024) Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer’s disease pathologies. Exp Mol Med 56(9):1936–1951
Article CAS PubMed Central PubMed Google Scholar
Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA (2013) Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol 190(10):5216–5225
Costa Franco MM, Marim F, Guimarães ES, Assis NRG, Cerqueira DM, Alves-Silva J, Harms J, Splitter G, Smith J, Kanneganti TD, de Queiroz N, Gutman D, Barber GN, Oliveira SC (2018) Brucella abortus triggers a cGAS-independent STING pathway to induce host protection that involves guanylate-binding proteins and inflammasome activation. J Immunol 200(2):607–622
Article CAS PubMed Google Scholar
Ding R, Li H, Liu Y, Ou W, Zhang X, Chai H, Huang X, Yang W, Wang Q (2022) Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis. J Neuroinflamm 19(1):137
Dogan E, Yildirim Z, Akalin T, Ozgiray E, Akinturk N, Aktan C, Solmaz AE, Biceroglu H, Caliskan KE, Ertan Y, Yurtseven T, Kosova B, Bozok V (2024) Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours. J Neurooncol 166(2):283–292
Article CAS PubMed Central PubMed Google Scholar
Dong X (2018) Current strategies for brain drug delivery. Theranostics 8(6):1481–1493
Comments (0)