Targeting Neuroinflammation in Preterm White Matter Injury: Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes

Abyadeh M, Mirshahvaladi S, Kashani SA et al (2024) Proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Impact of isolation methods on protein cargo. J Extracell Biol 3:e159. https://doi.org/10.1002/jex2.159

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahmad S, Choe K, Badshah H et al (2024) Physcion mitigates LPS-induced neuroinflammation, oxidative stress, and memory impairments via TLR-4/NF-кB signaling in adult mice. Pharmaceuticals (Basel). https://doi.org/10.3390/ph17091199

Article  PubMed  PubMed Central  Google Scholar 

Ahn SY, Sung DK, Kim YE et al (2021) Brain-derived neurotropic factor mediates neuroprotection of mesenchymal stem cell-derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats. Stem Cells Transl Med 10:374–384. https://doi.org/10.1002/sctm.20-0301

Article  PubMed  CAS  Google Scholar 

Al-Griw MA, Salter MG, Wood IC (2022) Blocking of NF-kB/p38 MAPK pathways mitigates oligodendrocyte pathology in a model of neonatal white matter injury. Acta Neurobiol Exp (Wars) 82:52–64. https://doi.org/10.55782/ane-2022-005

Article  PubMed  Google Scholar 

Back SA (2017) White matter injury in the preterm infant: pathology and mechanisms. Acta Neuropathol 134:331–349. https://doi.org/10.1007/s00401-017-1718-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Beacom MJ, Gunn AJ, Bennet L (2025) Preterm brain injury: mechanisms and challenges. Annu Rev Physiol 87:79–106. https://doi.org/10.1146/annurev-physiol-022724-104754

Article  PubMed  CAS  Google Scholar 

Bell EF, Hintz SR, Hansen NI et al (2022) Mortality, in-hospital morbidity, care practices, and 2-year outcomes for extremely preterm infants in the US, 2013–2018. JAMA 327:248–263. https://doi.org/10.1001/jama.2021.23580

Article  PubMed  Google Scholar 

Brandebura AN, Paumier A, Onur TS, Allen NJ (2023) Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat Rev Neurosci 24:23–39. https://doi.org/10.1038/s41583-022-00641-1

Article  PubMed  CAS  Google Scholar 

Brandt MJV, Kosmeijer CM, Achterberg EJM et al (2024) Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity. Brain Behav Immun Health 40:100817. https://doi.org/10.1016/j.bbih.2024.100817

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cao G, Liu J, Liu M (2022) Global, regional, and national incidence and mortality of neonatal preterm birth, 1990–2019. JAMA Pediatr 176:787–796. https://doi.org/10.1001/jamapediatrics.2022.1622

Article  PubMed  PubMed Central  Google Scholar 

Che J, Wang H, Dong J et al (2024) Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway. CNS Neurosci Ther 30:e14454. https://doi.org/10.1111/cns.14454

Article  PubMed  CAS  Google Scholar 

Ciesielska A, Matyjek M, Kwiatkowska K (2021) TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci 78:1233–1261. https://doi.org/10.1007/s00018-020-03656-y

Article  PubMed  CAS  Google Scholar 

Darwish SF, Elbadry AMM, Elbokhomy AS et al (2023) The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. Front Aging 4:1231706. https://doi.org/10.3389/fragi.2023.1231706

Article  PubMed  PubMed Central  Google Scholar 

Dave C, Mei SHJ, McRae A et al (2022) Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: a pre-clinical systematic review. Elife. https://doi.org/10.7554/eLife.75053

Article  PubMed  PubMed Central  Google Scholar 

Delavogia E, Ntentakis DP, Cortinas JA et al (2022) Mesenchymal stromal/stem cell extracellular vesicles and perinatal injury: one formula for many diseases. Stem Cells 40:991–1007. https://doi.org/10.1093/stmcls/sxac062

Article  PubMed  PubMed Central  Google Scholar 

Diao S, Xiao M, Chen C (2021) The role of hyaluronan in myelination and remyelination after white matter injury. Brain Res 1766:147522. https://doi.org/10.1016/j.brainres.2021.147522

Article  PubMed  CAS  Google Scholar 

Drommelschmidt K, Serdar M, Bendix I et al (2017) Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury. Brain Behav Immun 60:220–232. https://doi.org/10.1016/j.bbi.2016.11.011

Article  PubMed  CAS  Google Scholar 

Escartin C, Galea E, Lakatos A et al (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24:312–325. https://doi.org/10.1038/s41593-020-00783-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fang M, Yu Q, Ou J et al (2024) The neuroprotective mechanisms of PPAR-γ: inhibition of microglia-mediated neuroinflammation and oxidative stress in a neonatal mouse model of hypoxic-ischemic white matter injury. CNS Neurosci Ther 30:e70081. https://doi.org/10.1111/cns.70081

Article  PubMed  PubMed Central  CAS  Google Scholar 

Farfán N, Carril J, Redel M et al (2020) Intranasal administration of mesenchymal stem cell secretome reduces hippocampal oxidative stress, neuroinflammation and cell death, improving the behavioral outcome following perinatal asphyxia. Int J Mol Sci 5:46. https://doi.org/10.3390/ijms21207800

Article  CAS  Google Scholar 

Ferro A, Auguste YSS, Cheadle L (2021) Microglia, cytokines, and neural activity: unexpected interactions in brain development and function. Front Immunol 12:703527. https://doi.org/10.3389/fimmu.2021.703527

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fleiss B, Van Steenwinckel J, Bokobza C et al (2021) Microglia-mediated neurodegeneration in perinatal brain injuries. Biomolecules. https://doi.org/10.3390/biom11010099

Article  PubMed  PubMed Central  Google Scholar 

Fujita Y, Yamashita T (2020) Alterations in chromatin structure and function in the microglia. Front Cell Dev Biol 8:626541. https://doi.org/10.3389/fcell.2020.626541

Article  PubMed  Google Scholar 

Fuma K, Iitani Y, Imai K et al (2025) Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. Commun Biol 8:75. https://doi.org/10.1038/s42003-025-07511-3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao X, Gao LF, Kong XQ et al (2023a) Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy. Int Immunopharmacol 115:109695. https://doi.org/10.1016/j.intimp.2023.109695

Article  PubMed  CAS  Google Scholar 

Gao X, Gao LF, Zhang YN et al (2023b) Huc-MSCs-derived exosomes attenuate neuropathic pain by inhibiting activation of the TLR2/MyD88/NF-κB signaling pathway in the spinal microglia by targeting Rsad2. Int Immunopharmacol 114:109505. https://doi.org/10.1016/j.intimp.2022.109505

Article  PubMed  CAS  Google Scholar 

Ge Y, Wu J, Zhang L et al (2024) A new strategy for the regulation of neuroinflammation: exosomes derived from mesenchymal stem cells. Cell Mol Neurobiol 44:24. https://doi.org/10.1007/s10571-024-01460-x

Article  PubMed  PubMed Central  Google Scholar 

Giunti D, Marini C, Parodi B et al (2021) Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation. Sci Rep 11:1740. https://doi.org/10.1038/s41598-021-81039-4

Article

Comments (0)

No login
gif