LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review

Abbott NJ, Rönnbäck L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7(1):41–53

Article  CAS  PubMed  Google Scholar 

Anilkumar AK, Vij P, Lopez S, Leslie SM, Doxtater K, Khan MM et al (2024) Long non-coding RNAs: new insights in neurodegenerative diseases. Int J Mol Sci 25(4):2268

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai G, Jiang L, Meng P, Li J, Han C, Wang Y et al (2021) LncRNA Neat1 promotes regeneration after spinal cord injury by targeting miR-29b. J Mol Neurosci 71(6):1174–1184

Article  CAS  PubMed  Google Scholar 

Black CM, Braden AA, Nasim S, Tripathi M, Xiao J, Khan MM (2024) The association between long non-coding RNAs and Alzheimer’s disease. Brain Sci 14(8):818

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bridges MC, Daulagala AC, Kourtidis A (2021) LNCcation: lncRNA localization and function. J Cell Biol 220(2):e202009045. https://doi.org/10.1083/jcb.202009045

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai J, Shangguan S, Li G, Cai Y, Chen Y, Ma G et al (2019) Knockdown of lncRNA Gm11974 protect against cerebral ischemic reperfusion through miR-766-3p/NR3C2 axis. Artif Cells Nanomed Biotechnol 47(1):3847–3853

Article  CAS  PubMed  Google Scholar 

Cai LJ, Tu L, Huang XM, Huang J, Qiu N, Xie GH et al (2020a) LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease. Mol Brain 13(1):130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai X, Long L, Zeng C, Ni G, Meng Y, Guo Q et al (2020b) LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression. Aging (Albany NY) 12(9):8413–8422

Article  CAS  PubMed  Google Scholar 

Cao DW, Liu MM, Duan R, Tao YF, Zhou JS, Fang WR et al (2020c) The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation. Acta Pharmacol Sin 41(1):22–33

Article  PubMed  Google Scholar 

Cao Y, Tan X, Lu Q, Huang K, Tang X, He Z (2021a) MiR-29c-3p may promote the progression of Alzheimer’s disease through BACE1. J Healthc Eng 2021:2031407

Article  PubMed  PubMed Central  Google Scholar 

Cao Y, Jiang C, Lin H, Chen Z (2021b) Silencing of long noncoding RNA growth arrest-specific 5 alleviates neuronal cell apoptosis and inflammatory responses through sponging microRNA-93 to repress PTEN expression in spinal cord injury. Front Cell Neurosci 15:646788

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chanda K, Mukhopadhyay D (2020) LncRNA Xist, X-chromosome instability and Alzheimer’s disease. Curr Alzheimer Res 17(6):499–507

Article  CAS  PubMed  Google Scholar 

Chanda K, Das S, Chakraborty J, Bucha S, Maitra A, Chatterjee R et al (2018) Altered Levels of Long NcRNAs Meg3 and Neat1 in Cell And Animal Models Of Huntington’s Disease. RNA Biol 15(10):1348–1363

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Chopp M (2018) Exosome therapy for stroke. Stroke 49(5):1083–1090

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Li X (2019) LncRNA ROR is involved in cerebral hypoxia/reoxygenation-induced injury in PC12 cells via regulating miR-135a-5p/ROCK1/2. Am J Transl Res 11(9):6145–6158

CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Huang Y, Xia P, Zhang F, Li L, Wang E et al (2021a) Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis. Eur J Histochem. 65(3):3224

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, Lai X, Wang X, Ying J, Zhang L, Zhou B et al (2021b) Long non-coding RNAs and circular RNAs: insights into microglia and astrocyte mediated neurological diseases. Front Mol Neurosci 14:745066

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Wei Z, Liu J, Xie H, Wang B, Wu J et al (2021c) Long noncoding RNA ZFAS1 aggravates spinal cord injury by binding with miR-1953 and regulating the PTEN/PI3K/AKT pathway. Neurochem Int 147:104977

Article  CAS  PubMed  Google Scholar 

Chen C, Zhang S, Wei Y, Sun X (2022a) LncRNA RMST regulates neuronal apoptosis and inflammatory response via sponging miR-150-5p in Parkinson’s disease. NeuroImmunoModulation 29(1):55–62

Article  PubMed  Google Scholar 

Chen X, Xie Y, Liang C, Yang D, Li X, Yu J (2022b) Tug1 Acts on ERK12 signaling pathway to aggravate neuronal damage after acute ischemic stroke. Cell Mol Biol (Noisy-le-grand) 68(1):51–58

Article  PubMed  Google Scholar 

Chen Y, Mateski J, Gerace L, Wheeler J, Burl J, Prakash B et al (2024) Non-coding RNAs and neuroinflammation: implications for neurological disorders. Exp Biol Med (Maywood) 249:10120

Article  PubMed  Google Scholar 

Cheng J, Duan Y, Zhang F, Shi J, Li H, Wang F et al (2021a) The role of lncRNA TUG1 in the Parkinson disease and its effect on microglial inflammatory response. Neuromolecular Med 23(2):327–334

Article  CAS  PubMed  Google Scholar 

Cheng S, Zhang Y, Chen S, Zhou Y (2021b) LncRNA HOTAIR participates in microglia activation and inflammatory factor release by regulating the ubiquitination of MYD88 in traumatic brain injury. J Mol Neurosci 71(1):169–177

Article  CAS  PubMed  Google Scholar 

Choi SW, Kim HW, Nam JW (2019) The small peptide world in long noncoding RNAs. Brief Bioinform 20(5):1853–1864

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu Z, Lu Y, Qin R, Dong Y (2022) LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury. An Acad Bras Cienc 94(2):e20210188

Article  CAS  PubMed  Google Scholar 

Cipriano GL, Schepici G, Mazzon E, Anchesi I (2024) Multiple sclerosis: roles of miRNA, lcnRNA, and circRNA and their implications in cellular pathways. Int J Mol Sci 25(4):2255. https://doi.org/10.3390/ijms25042255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corey-Bloom J, Jia H, Aikin AM, Thomas EA (2014) Disease modifying potential of glatiramer acetate in Huntington’s disease. J Huntingtons Dis 3(3):311–316

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui Y, Yin Y, Xiao Z, Zhao Y, Chen B, Yang B et al (2019) LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells. Stem Cell Res Ther 10(1):400

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui SY, Zhang W, Cui ZM, Yi H, Xu DW, Liu W et al (2021) Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury. J Orthop Surg Res 16(1):6

Article  PubMed  PubMed Central  Google Scholar 

DiSabato DJ, Quan N, Godbout JP (2016) Neuroinflammation: the devil is in the details. J Neurochem 139(Suppl 2):136–153

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