Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder

Arteaga-Henríquez G, Lugo-Marín J, Gisbert L et al (2022) Activation of the monocyte/macrophage system and abnormal blood levels of lymphocyte subpopulations in individuals with autism spectrum disorder: a systematic review and meta-analysis. Int J Mol Sci 23:14329. https://doi.org/10.3390/ijms232214329

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker JF, Ghio AJ (2009) Iron homoeostasis in rheumatic disease. Rheumatology (Oxford) 48:1339–1344. https://doi.org/10.1093/rheumatology/kep221

Bener A, Khattab AO, Bhugra D, Hoffmann GF (2017) Iron and vitamin D levels among autism spectrum disorders children. Ann Afr Med 16:186–191. https://doi.org/10.4103/aam.aam_17_17

Article  PubMed  PubMed Central  Google Scholar 

Bjørklund G, Meguid NA, El-Bana MA et al (2020) Oxidative stress in autism spectrum disorder. Mol Neurobiol 57:2314–2332. https://doi.org/10.1007/s12035-019-01742-2

Article  CAS  PubMed  Google Scholar 

Campbell RK, Buhimschi CS, Zhao G et al (2022) Prevalence of and risk factors for iron deficiency in twin and singleton newborns. Nutrients 14:3854. https://doi.org/10.3390/nu14183854

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheli VT, Correale J, Paez PM, Pasquini JM (2020) Iron metabolism in oligodendrocytes and astrocytes, implications for myelination and remyelination. ASN Neuro 12:1759091420962681. https://doi.org/10.1177/1759091420962681

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Fu Q, Du Y et al (2023) Transcriptome analysis and epigenetics regulation in the hippocampus and the prefrontal cortex of VPA-induced rat model. Mol Neurobiol. https://doi.org/10.1007/s12035-023-03560-z

Article  PubMed  PubMed Central  Google Scholar 

Cuomo BM, Vaz S, Lee EAL et al (2017) Effectiveness of sleep-based interventions for children with autism spectrum disorder: a meta-synthesis. Pharmacotherapy 37:555–578. https://doi.org/10.1002/phar.1920

Article  PubMed  Google Scholar 

David S, Jhelum P, Ryan F et al (2022) Dysregulation of iron homeostasis in the central nervous system and the role of ferroptosis in neurodegenerative disorders. Antioxid Redox Signal 37:150–170. https://doi.org/10.1089/ars.2021.0218

Article  CAS  PubMed  Google Scholar 

De Giacomo A, Medicamento S, Pedaci C et al (2022) Peripheral iron levels in autism spectrum disorders vs. other neurodevelopmental disorders: preliminary data. Int J Environ Res Public Health 19:4006. https://doi.org/10.3390/ijerph19074006

Du Y, Chen L, Yan M-C et al (2023) Neurometabolite levels in the brains of patients with autism spectrum disorders: a meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501). Mol Psychiatry. https://doi.org/10.1038/s41380-023-02079-y

Article  PubMed  PubMed Central  Google Scholar 

Dusek P, Hofer T, Alexander J et al (2022) Cerebral iron deposition in neurodegeneration. Biomolecules 12:714. https://doi.org/10.3390/biom12050714

East P, Doom JR, Blanco E et al (2021) Iron deficiency in infancy and neurocognitive and educational outcomes in young adulthood. Dev Psychol 57:962–975. https://doi.org/10.1037/dev0001030

Article  PubMed  PubMed Central  Google Scholar 

Elhodaky M, Diamond AM (2018) Selenium-binding protein 1 in human health and disease. Int J Mol Sci 19:3437. https://doi.org/10.3390/ijms19113437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gesundheit B, Rosenzweig JP, Naor D et al (2013) Immunological and autoimmune considerations of autism spectrum disorders. J Autoimmun 44:1–7. https://doi.org/10.1016/j.jaut.2013.05.005

Article  CAS  PubMed  Google Scholar 

Ghosh MC, Zhang D-L, Rouault TA (2015) Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins. Neurobiol Dis 81:66–75. https://doi.org/10.1016/j.nbd.2015.02.026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gillberg C, Fernell E, Kočovská E et al (2017) The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: a hypothesis paper. Autism Res 10:1022–1044. https://doi.org/10.1002/aur.1777

Article  PubMed  PubMed Central  Google Scholar 

Gu X, Lai D, Liu S et al (2022) Hub genes, diagnostic model, and predicted drugs related to iron metabolism in Alzheimer’s disease. Front Aging Neurosci 14:949083. https://doi.org/10.3389/fnagi.2022.949083

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gunes S, Ekinci O, Celik T (2017) Iron deficiency parameters in autism spectrum disorder: clinical correlates and associated factors. Ital J Pediatr 43:86. https://doi.org/10.1186/s13052-017-0407-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gyawali S, Patra BN (2019) Autism spectrum disorder: trends in research exploring etiopathogenesis. Psychiatry Clin Neurosci 73:466–475. https://doi.org/10.1111/pcn.12860

Article  PubMed  Google Scholar 

Hare D, Ayton S, Bush A, Lei P (2013) A delicate balance: iron metabolism and diseases of the brain. Front Aging Neurosci 5:34. https://doi.org/10.3389/fnagi.2013.00034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haschka D, Hoffmann A, Weiss G (2021) Iron in immune cell function and host defense. Semin Cell Dev Biol 115:27–36. https://doi.org/10.1016/j.semcdb.2020.12.005

Article  CAS  PubMed  Google Scholar 

Hergüner S, Keleşoğlu FM, Tanıdır C, Cöpür M (2012) Ferritin and iron levels in children with autistic disorder. Eur J Pediatr 171:143–146. https://doi.org/10.1007/s00431-011-1506-6

Article  CAS  PubMed  Google Scholar 

Heyer NJ, Echeverria D, Woods JS (2012) Disordered porphyrin metabolism: a potential biological marker for autism risk assessment. Autism Res 5:84–92. https://doi.org/10.1002/aur.236

Article  PubMed  PubMed Central  Google Scholar 

Hoffbrand AV (2009) Recent advances in the understanding of iron metabolism and iron-related diseases. Acta Haematol 122:75–77. https://doi.org/10.1159/000243790

Article  CAS  PubMed  Google Scholar 

Huang L, Bian M, Zhang J, Jiang L (2022) Iron metabolism and ferroptosis in peripheral nerve injury. Oxid Med Cell Longev 2022:5918218. https://doi.org/10.1155/2022/5918218

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes HK, Mills Ko E, Rose D, Ashwood P (2018) Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders. Front Cell Neurosci 12:405. https://doi.org/10.3389/fncel.2018.00405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hyman SL, Levy SE, Myers SM (2020) Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics 145:e20193447. https://doi.org/10.1542/peds.2019-3447

Article  PubMed  Google Scholar 

Katz J, Reichenberg A, Kolevzon A (2021) Prenatal and perinatal metabolic risk factors for autism: a review and integration of findings from population-based studies. Curr Opin Psychiatry 34:94–104. https://doi.org/10.1097/YCO.0000000000000673

Article  PubMed  PubMed Central  Google Scholar 

Kumar S, Reynolds K, Ji Y et al (2019) Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. J Neurodev Disord 11:10. https://doi.org/10.1186/s11689-019-9268-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lai X, Wu X, Hou N et al (2018) Vitamin A deficiency induces autistic-like behaviors in rats by regulating the RARβ-CD38-oxytocin axis in the hypothalamus. Mol Nutr Food Res 62. https://doi.org/10.1002/mnfr.201700754

Li H, Xu Y, Li W et al (2022) Novel insights into the immune cell landscape and gene signatures in autism spectrum disorder by bioinformatics and clinical analysis. Front Immunol 13:1082950. https://doi.org/10.3389/fimmu.2022.1082950

Article  CAS  PubMed  Google Scholar 

Li X, Chauhan A, Sheikh AM et al (2009) Elevated immune response in the brain of autistic patients. J Neuroimmunol 207:111–116. https://doi.org/10.1016/j.jneuroim.2008.12.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Yang Z, Du Y et al (2022) Antioxidant interventions in autism spectrum disorders: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 113:110476. https://doi.org/10.1016/j.pnpbp.2021.110476

Article  PubMed  Google Scholar 

Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J (2018) Autism spectrum disorder. Lancet 392:508–520. https://doi.org/10.1016/S0140-6736(18)31129-2

Maenner MJ, Shaw KA, Bakian AV et al (2021) Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2018. MMWR Surveill Summ 70:1–16. https://doi.org/10.15585/mmwr.ss7011a1

Maenner MJ, Warren Z, Williams AR et al (2023) Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2020. MMWR Surveill Summ 72:1–14. https://doi.org/10.15585/mmwr.ss7202a1

Mead J, Ashwood P (2015) Evidence supporting an altered immune response in ASD. Immunol Lett 163:49–55. https://doi.org/10.1016/j.imlet.2014.11.006

Article  CAS  PubMed  Google Scholar 

Meltzer A, Van de Water J (2017) The role of t

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