Glutamine Metabolism Heterogeneity in Glioblastoma Unveils an Innovative Combination Therapy Strategy

Bikfalvi A, da Costa CA, Avril T et al (2023) Challenges in glioblastoma research: focus on the tumor microenvironment. Trends Cancer 9:9–27

Article  CAS  PubMed  Google Scholar 

Cai X, Miao J, Sun R et al (2021) Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer. Pharmacol Res 170:105701

Chen A, Jiang Y, Li Z et al (2021) Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. J Clin Invest 131:16

Chen Y, Mi Y, Zhang X et al (2019) Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells. J Exp Clin Cancer Res 38:402

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhary N, Osorio RC, Oh JY, Aghi MK (2023) Metabolic barriers to glioblastoma immunotherapy. Cancers (Basel) 15:5

Chung S, Sugimoto Y, Huang J, Zhang M (2023) Iron oxide nanoparticles decorated with functional peptides for a targeted siRNA delivery to glioma cells. ACS Appl Mater Interfaces 15:106–119

Article  CAS  PubMed  Google Scholar 

De Los Santos-Jiménez J, Rosales T, Ko B et al (2023) Metabolic adjustments following glutaminase inhibition by CB-839 in glioblastoma cell lines. Cancers (Basel) 15:2

Dunphy MPS, Harding JJ, Venneti S et al (2018) In vivo PET assay of tumor glutamine flux and metabolism: in-human trial of (18)F-(2S,4R)-4-fluoroglutamine. Radiology 287:667–675

Article  PubMed  Google Scholar 

Fang YJ, Wu M, Chen HN et al (2021) Carnosine suppresses human glioma cells under normoxic and hypoxic conditions partly via inhibiting glutamine metabolism. Acta Pharmacol Sin 42:767–779

Article  CAS  PubMed  Google Scholar 

Friedman J, Hastie T, Tibshirani R (2010) Regularization paths for generalized linear models via coordinate descent. J Stat Softw 33:1–22

Article  PubMed  PubMed Central  Google Scholar 

Geeleher P, Cox N, Huang RS (2014) pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One 9:e107468

Article  PubMed  PubMed Central  Google Scholar 

Ge C, Zhu X, Niu X et al (2021) A transcriptome profile in gallbladder cancer based on annotation analysis of microarray studies. Mol Med Rep 23:1

Ghosh D, Ulasov IV, Chen L et al (2016) TGFβ-responsive HMOX1 Expression is associated with stemness and invasion in glioblastoma multiforme. Stem Cells 34:2276–2289

Article  CAS  PubMed  Google Scholar 

Gielen PR, Schulte BM, Kers-Rebel ED et al (2016) Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function. Neuro Oncol 18:1253–1264

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gravendeel LA, Kouwenhoven MC, Gevaert O et al (2009) Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res 69:9065–9072

Article  CAS  PubMed  Google Scholar 

Hänzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7

Article  PubMed  PubMed Central  Google Scholar 

Hoogstrate Y, Draaisma K, Ghisai SA et al (2023) Transcriptome analysis reveals tumor microenvironment changes in glioblastoma. Cancer Cell 41:678-692.e677

Article  CAS  PubMed  Google Scholar 

Hou K, Liu J, Du J et al (2021) Dihydroartemisinin prompts amplification of photodynamic therapy-induced reactive oxygen species to exhaust Na/H exchanger 1-mediated glioma cells invasion and migration. J Photochem Photobiol B 219:112192

Article  CAS  PubMed  Google Scholar 

Hu J, Yu A, Othmane B et al (2021) Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer. Theranostics 11:3089–3108

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji X, Liu Z, Gao J et al (2023) N(6)-Methyladenosine-modified lncRNA LINREP promotes glioblastoma progression by recruiting the PTBP1/HuR complex. Cell Death Differ 30:54–68

Article  CAS  PubMed  Google Scholar 

Kim SH, Kang SH, Kang BS (2016) Therapeutic effects of dihydroartemisinin and transferrin against glioblastoma. Nutr Res Pract 10:393–397

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koch K, Hartmann R, Tsiampali J et al (2020) A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity. Cell Death Discov 6:20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leone RD, Zhao L, Englert JM et al (2019) Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science 366:1013–1021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Zhu H, Sun W et al (2021) Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells. Cancer Cell Int 21:479

Article  PubMed  PubMed Central  Google Scholar 

Li F, Qi B, Yang L et al (2022) CHI3L1 predicted in malignant entities is associated with glioblastoma immune microenvironment. Clin Immunol 245:109158

Article  CAS  PubMed  Google Scholar 

Liberzon A, Birger C, Thorvaldsdóttir H et al (2015) The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst 1:417–425

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magri S, Musca B, Pinton L et al (2022) The immunosuppression pathway of tumor-associated macrophages is controlled by heme oxygenase-1 in glioblastoma patients. Int J Cancer 151:2265–2277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Majewska E, Márquez J, Albrecht J, Szeliga M (2019) Transfection with GLS2 glutaminase (GAB) sensitizes human glioblastoma cell lines to oxidative stress by a common mechanism involving suppression of the PI3K/AKT pathway. Cancers (Basel) 11:1

Martins F, van der Kellen D, Goncalves LG, Serpa J (2023) Metabolic profiles point out metabolic pathways pivotal in two glioblastoma (GBM) cell lines, U251 and U-87MG. Biomedicines 11:7

Newman AM, Liu CL, Green MR et al (2015) Robust enumeration of cell subsets from tissue expression profiles. Nat Methods 12:453–457

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng P, Zhu H, Liu D et al (2022) TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling. Theranostics 12:4221–4236

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu C, Ma J, Liu X et al (2017) Dihydroartemisinin exerts anti-tumor activity by inducing mitochondrion and endoplasmic reticulum apoptosis and autophagic cell death in human glioblastoma cells. Front Cell Neurosci 11:310

Article  PubMed  PubMed Central  Google Scholar 

Que Z, Wang P, Hu Y et al (2017) Dihydroartemisin inhibits glioma invasiveness via a ROS to P53 to β-catenin signaling. Pharmacol Res 119:72–88

Article  CAS  PubMed  Google Scholar 

Rehman FU, Liu Y, Yang Q et al (2022) Heme oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy. J Control Release 345:696–708

Article  CAS  PubMed  Google Scholar 

Sabu A, Liu TI, Ng SS et al (2023) Nanomedicines targeting glioma stem cells. ACS Appl Mater Interfaces 15:158–181

Article  CAS  PubMed  Google Scholar 

Sidoryk M, Matyja E, Dybel A, Zielinska M, Bogucki J, Jaskólski DJ, Liberski PP, Kowalczyk P, Albrecht J (2004) Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. Neuroreport 15:575–578

Article  CAS 

Comments (0)

No login
gif