Bettencourt-Silva R, Aguiar B, Sá-Araújo V et al (2019) Diabetes-related symptoms, acute complications and management of diabetes mellitus of patients who are receiving palliative care: a protocol for a systematic review. BMJ Open 9(6):1–5. https://doi.org/10.1136/bmjopen-2018-028604

Article  Google Scholar 

Bregman JA, Herren DJ, Estopinal CB, Chocron IM, Harlow PA, Warden C, Brantley MA, Samuels DC (2017) Mitochondrial haplogroups affect severity but not prevalence of diabetic retinopathy. Investig Ophthalmol vis Sci 58:1346–1351. https://doi.org/10.1167/iovs.16-20616

Article  CAS  Google Scholar 

Cai X, Li J, Wang M, She M, Tang Y, Li J, Li H, Hui H (2017) GLP-1 treatment improves diabetic retinopathy by alleviating autophagy through GLP-1R-ERK1/2-HDAC6 signaling pathway. Int J Med Sci 14:1203–1212. https://doi.org/10.7150/ijms.20962

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Ko KM (2013) Ursolic-acid-enriched herba cynomorii extract protects against oxidant injury in H9c2 cells and rat myocardium by increasing mitochondrial ATP generation capacity and enhancing cellular glutathione redox cycling, possibly through mitochondrial uncoupling. Evidence-based Complement Altern Med https://doi.org/10.1155/2013/924128

Ekberg NR, Eliasson S, Li YW, Zheng X, Chatzidionysiou K, Falhammar H, Gu HF, Catrina SB (2019) Protective effect of the HIF-1A Pro582Ser polymorphism on severe diabetic retinopathy. J. Diabetes Res https://doi.org/10.1155/2019/2936962

Fan Y, Liu K, Wang Q, Ruan Y, Zhang Y, Ye W (2014) Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2/Bax and Bcl-xL/Bax ratios and reducing reactive gliosis. Mol vis 20:1557–1568

CAS  PubMed  PubMed Central  Google Scholar 

Fang W, Wang C, He Y, Zhou Y, Peng X, Liu S (2017) Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation. Acta Pharmacol. Sin. 1–15 https://doi.org/10.1038/aps.2017.50

Feenstra DJ, Yego EC, Mohr S (2013) Modes of retinal cell death in diabetic retinopathy. J Clin Exp Ophthalmol 4(5):298. https://doi.org/10.4172/2155-9570.1000298

Article  PubMed  PubMed Central  Google Scholar 

Han WH, Gotzmann J, Kuny S, Huang H, Chan CB, Lemieux H, Sauvé Y (2017) Modifications in retinal mitochondrial respiration precede type 2 diabetes and protracted microvascular retinopathy. Investig Ophthalmol vis Sci 58:3826–3839. https://doi.org/10.1167/iovs.17-21929

Article  CAS  Google Scholar 

Hsu YJ, Lin CW, Cho SL, Yang WS, Yang CM, Yang CH (2020) Protective effect of fenofibrate on oxidative stress-induced apoptosis in retinal–choroidal vascular endothelial cells: implication for diabetic retinopathy treatment. Antioxidants 9:1–18. https://doi.org/10.3390/antiox9080712

Article  CAS  Google Scholar 

Huang X, Sun L, Ji S, Zhao T, Zhang W, Xu J, Zhang J, Wang Y, Wang X, Franzini-Armstrong C, Zheng M, Cheng H (2013) Kissing and nanotunneling mediate intermitochondrial communication in the heart. Proc Natl Acad Sci USA 110:2846–2851. https://doi.org/10.1073/pnas.1300741110

Article  PubMed  PubMed Central  Google Scholar 

Kiu H, Nicholson SE (2012) Biology and significance of the JAK/STAT signalling pathways. Growth Factors 30:88–106. https://doi.org/10.3109/08977194.2012.660936

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kowluru RA (2005) Diabetic retinopathy: mitochondrial dysfunction and retinal capillary cell death. Antioxid Redox Signal 7:1581–1587. https://doi.org/10.1089/ars.2005.7.1581

Article  CAS  PubMed  Google Scholar 

Kowluru RA, Mishra M (2015) Oxidative stress, mitochondrial damage and diabetic retinopathy. Biochim Biophys Acta - Mol Basis Dis 1852:2474–2483. https://doi.org/10.1016/j.bbadis.2015.08.001

Article  CAS  Google Scholar 

Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry, 1st ed, Methods in Enzymology. Elsevier Inc. https://doi.org/10.1016/B978-0-12-416618-9.00009-1

Lei X, He J, Ren C, Zhou Y, Chen X, Dou J (2018) Protective effects of the Chinese herbal medicine prescription Zhujing pill on retina of streptozotocin-induced diabetic rats. Biomed Pharmacother 98:643–650. https://doi.org/10.1016/j.biopha.2017.12.071

Article  PubMed  Google Scholar 

Li K, Cui YC, Zhang H, Liu XP, Zhang D, Wu AL, Li JJ, Tang Y (2015) Glutamine reduces the apoptosis of H9C2 cells treated with high-glucose and reperfusion through an oxidation-related mechanism. PLoS ONE 10:1–16. https://doi.org/10.1371/journal.pone.0132402

Article  CAS  Google Scholar 

Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z (2018) Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med 120:228–238. https://doi.org/10.1016/j.freeradbiomed.2018.03.014

Article  CAS  PubMed  Google Scholar 

Liu WY, Liou SS, Hong TY, Liu IM (2017) Protective effects of hesperidin (Citrus flavonone) on high glucose induced oxidative stress and apoptosis in a cellular model for diabetic retinopathy. Nutrients 9. https://doi.org/10.3390/nu9121312

Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319–1338. https://doi.org/10.3390/biom5031319

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maleškić S, Kusturica J, Gušić E, Rakanović-Todić M, Šečić D, Burnazović-Ristić L, Kulo A (2017) Metformin use associated with protective effects for ocular complications in patients with type 2 diabetes - observational study. Acta Med Acad 46:116–123. https://doi.org/10.5644/ama2006-124.196

Article  PubMed  Google Scholar 

Mehrzadi S, Motevalian M, Rezaei Kanavi M, Fatemi I, Ghaznavi H, Shahriari M (2018) Protective effect of melatonin in the diabetic rat retina. Fundam Clin Pharmacol 32:414–421. https://doi.org/10.1111/fcp.12361

Article  CAS  PubMed  Google Scholar 

Miller DJ, Cascio MA, Rosca MG (2020) Diabetic retinopathy: the role of mitochondria in the neural retina and microvascular disease. Antioxidants 9:1–29. https://doi.org/10.3390/antiox9100905

Article  CAS  Google Scholar 

Mujkošová J, Ferko M, Humeník P, Waczulíková I, Ziegelhffer A (2008) Seasonal variations in properties of healthy and diabetic rat heart mitochondria: Mg2+-ATPase activity, content of conjugated dienes and membrane fluidity. Physiol Res 57. https://doi.org/10.33549/physiolres.931555

Nishikawa T, Araki E (2007) Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications. Antioxid Redox Signal 9:343–353. https://doi.org/10.1089/ars.2006.1458

Article  CAS  PubMed  Google Scholar 

Osorio-Paz I, Uribe-Carvajal S, Salceda R (2015) In the early stages of diabetes, rat retinal mitochondria undergo mild uncoupling due to UCP2 activity. PLoS ONE 10:1–15. https://doi.org/10.1371/journal.pone.0122727

Article  CAS  Google Scholar 

Perez-gutierrez RM, Garcia-campoy AH, Muñiz-ramirez A (2016). Properties of Flavonoids Isolated from the Bark of Eysenhardtia Polystachya and Their Effect on Oxidative Stress in Streptozotocin-Induced Diabetes Mellitus in Mice. https://doi.org/10.1155/2016/9156510

Article  Google Scholar 

Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid. Med. Cell. Longev https://doi.org/10.1155/2019/6521218

Sadikan MZ, Nasir NAA, Agarwal R, Ismail NM (2020) Protective effect of palm oil-derived tocotrienol-rich fraction against retinal neurodegenerative changes in rats with streptozotocin-induced diabetic retinopathy. Biomolecules 10. https://doi.org/10.3390/biom10040556

Sun X, Chen R, Yang Z, Sun G, Wang M, Ma X, Yang L, Sun XB (2014) Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol 63:221–232. https://doi.org/10.1016/j.fct.2013.11.013

Article  CAS  PubMed  Google Scholar 

Sun Z, Lan X, Ahsan A, Xi Y, Liu S, Zhang Z, Chu P, Song Y, Piao F, Peng J, Lin Y, Han G, Tang Z (2016) Erratum to: Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation. Apoptosis 21:514–515. https://doi.org/10.1007/s10495-016-1215-8

Article  PubMed  Google Scholar 

Taegtmeyer H, Ingwall JS (2013) Creatine-A dispensable metabolite? Circ Res 112:878–880. https://doi.org/10.1161/CIRCRESAHA.113.300974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Villarroel M (2010) Neurodegeneration: an early event of diabetic retinopathy. World J Diabetes 1:57. https://doi.org/10.4239/wjd.v1.i2.57

Article  PubMed  PubMed Central  Google Scholar 

Wang Q, Navitskaya S, Chakravarthy H, Huang C, Kady N, Lydic TA, Chen YE, Yin KJ, Powell FL, Martin PM, Grant MB, Busik JV (2016) Dual anti-inflammatory and anti-angiogenic action of miR-15a in diabetic retinopathy. EBioMedicine 11:138–150. https://doi.org/10.1016/j.ebiom.2016.08.013

Article  PubMed  PubMed Central  Google Scholar 

Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z (2022) Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways. Cell Biol Toxicol 38:531–551. https://doi.org/10.1007/s10565-021-09644-7

Article  CAS  PubMed  Google Scholar 

Zhong Q, Kowluru RA (2011) Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Investig Ophthalmol vis Sci 52:8739–8746. https://doi.org/10.1167/iovs.11-8045

Article  CAS  Google Scholar 

Zhu X, Wang K, Zhang K, Tan X, Wu Z, Sun S, Zhou F, Zhu L (2015) Tetramethylpyrazine protects retinal capillary endothelial cells (TR-iBRB2) against IL-1β-induced nitrative/oxidative stress. Int J Mol Sci 16:21775–21790. https://doi.org/10.3390/ijms160921775

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu XF, Zou HD (2012) PEDF in diabetic retinopathy: a protective effect of oxidative stress. J Biomed Biotechnol https://doi.org/10.1155/2012/580687