Absalon S, Kochanek DM, Raghavan V, Krichevsky AM (2013) MiR-26b, upregulated in Alzheimer’s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 33(37):14645–14659. https://doi.org/10.1523/JNEUROSCI.1327-13.2013
Article CAS PubMed PubMed Central Google Scholar
Arendt T (2012) Cell cycle activation and aneuploid neurons in Alzheimer’s disease. Mol Neurobiol 46(1):125–135. https://doi.org/10.1007/s12035-012-8262-0
Article CAS PubMed Google Scholar
Arendt T, Mosch B, Morawski M (2009) Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons. Int J Mol Sci 10(4):1609–1627. https://doi.org/10.3390/ijms10041609
Article CAS PubMed PubMed Central Google Scholar
Arendt T, Bruckner MK, Mosch B, Losche A (2010) Selective cell death of hyperploid neurons in Alzheimer’s disease. Am J Pathol 177(1):15–20. https://doi.org/10.2353/ajpath.2010.090955
Article CAS PubMed PubMed Central Google Scholar
Arendt T, Stieler J, Ueberham U (2017) Is sporadic Alzheimer’s disease a developmental disorder? J Neurochem 143(4):396–408. https://doi.org/10.1111/jnc.14036
Article CAS PubMed Google Scholar
Bajic G, Degn SE, Thiel S, Andersen GR (2015) Complement activation, regulation, and molecular basis for complement-related diseases. EMBO J 34(2):2735–2757. https://doi.org/10.15252/embj.201591881
Article CAS PubMed PubMed Central Google Scholar
Barnham KJ, Masters CL, Bush AI (2004) Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 3(3):205–214. https://doi.org/10.1038/nrd1330
Article CAS PubMed Google Scholar
Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Bjork-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisen J (2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A 103(33):12564–12568. https://doi.org/10.1073/pnas.0605177103
Article CAS PubMed PubMed Central Google Scholar
Boeras DI, Granic A, Padmanabhan J, Crespo NC, Rojiani AM, Potter H (2008) Alzheimer’s presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiol Aging 29(3):319–328. https://doi.org/10.1016/j.neurobiolaging.2006.10.027
Article CAS PubMed Google Scholar
Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ (2018) Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 22(4):589-599 e585. https://doi.org/10.1016/j.stem.2018.03.015
Article CAS PubMed PubMed Central Google Scholar
Buckton KE, Whalley LJ, Lee M, Christie JE (1982) Chromosome aneuploidy in Alzheimer’s disease. Exp Brain Res, Suppl 5:58–63. https://doi.org/10.1007/978-3-642-68507-1_9
Buckton KE, Whalley LJ, Lee M, Christie JE (1983) Chromosome changes in Alzheimer’s presenile dementia. J Med Genet 20(1):46–51. https://doi.org/10.1136/jmg.20.1.46
Article CAS PubMed PubMed Central Google Scholar
Buffin E, Emre D, Karess RE (2007) Flies without a spindle checkpoint. Nat Cell Biol 9(5):565–572. https://doi.org/10.1038/ncb1570
Article CAS PubMed Google Scholar
Caneus J, Granic A, Rademakers R, Dickson DW, Coughlan CM, Chial HJ, Potter H (2018) Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations. Mol Biol Cell 29(5):575–586. https://doi.org/10.1091/mbc.E17-01-0031
Article CAS PubMed PubMed Central Google Scholar
Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, Lee JC, Tabb LP, Saunders AJ, Marenda DR (2011) Characterization of a Drosophila Alzheimer’s disease model: pharmacological rescue of cognitive defects. PLoS ONE 6(6):e20799. https://doi.org/10.1371/journal.pone.0020799
Article CAS PubMed PubMed Central Google Scholar
Culig L, Chu X, Bohr VA (2022) Neurogenesis in aging and age-related neurodegenerative diseases. Ageing Res Rev 78:101636. https://doi.org/10.1016/j.arr.2022.101636
Article CAS PubMed PubMed Central Google Scholar
Devalle S, Sartore RC, Paulsen BS, Borges HL, Martins RA, Rehen SK (2012) Implications of aneuploidy for stem cell biology and brain therapeutics. Front Cell Neurosci 6:36. https://doi.org/10.3389/fncel.2012.00036
Article PubMed PubMed Central Google Scholar
Faggioli F, Vijg J, Montagna C (2011) Chromosomal aneuploidy in the aging brain. Mech Ageing Dev 132(8–9):429–436. https://doi.org/10.1016/j.mad.2011.04.008
Article CAS PubMed PubMed Central Google Scholar
Fantin F, Macchi F, Giani A, Bissoli L (2019) The importance of nutrition in hypertension. Nutrients 11(10). https://doi.org/10.3390/nu11102542
Farmer BC, Walsh AE, Kluemper JC, Johnson LA (2020) Lipid droplets in neurodegenerative disorders. Front Neurosci 14:742. https://doi.org/10.3389/fnins.2020.00742
Article PubMed PubMed Central Google Scholar
Fischer HG, Morawski M, Bruckner MK, Mittag A, Tarnok A, Arendt T (2012) Changes in neuronal DNA content variation in the human brain during aging. Aging Cell 11(4):628–633. https://doi.org/10.1111/j.1474-9726.2012.00826.x
Article CAS PubMed Google Scholar
Geller LN, Potter H (1999) Chromosome missegregation and trisomy 21 mosaicism in Alzheimer’s disease. Neurobiol Dis 6(3):167–179. https://doi.org/10.1006/nbdi.1999.0236
Article CAS PubMed Google Scholar
Granic A, Padmanabhan J, Norden M, Potter H (2010) Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Mol Biol Cell 21(4):511–520. https://doi.org/10.1091/mbc.E09-10-0850
Article CAS PubMed PubMed Central Google Scholar
Haynes CM, Titus EA, Cooper AA (2004) Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell 15(5):767–776. https://doi.org/10.1016/j.molcel.2004.08.025
Article CAS PubMed Google Scholar
Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL (2013) Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci 33(4):1651–1659. https://doi.org/10.1523/JNEUROSCI.3191-12.2013
Article CAS PubMed PubMed Central Google Scholar
Ibrahim S, Hu W, Wang X, Gao X, He C, Chen J (2016) Traumatic brain injury causes aberrant migration of adult-born neurons in the hippocampus. Sci Rep 6:21793. https://doi.org/10.1038/srep21793
Article CAS PubMed PubMed Central Google Scholar
Iourov IY, Vorsanova SG, Yurov YB (2006) Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses. Int Rev Cytol 249:143–191. https://doi.org/10.1016/S0074-7696(06)49003-3
Comments (0)