Akyol S, Ugur Z, Yilmaz A et al (2021) Lipid profiling of Alzheimer’s disease brain highlights enrichment in glycerol (phospho) lipid, and sphingolipid metabolism. Cells. https://doi.org/10.3390/cells10102591
Article PubMed PubMed Central Google Scholar
Altendorfer B, Unger MS, Poupardin R et al (2022) Transcriptomic profiling identifies CD8(+) T cells in the brain of aged and Alzheimer’s disease transgenic mice as tissue-resident memory T cells. J Immunol 209:1272–1285. https://doi.org/10.4049/jimmunol.2100737
Article CAS PubMed PubMed Central Google Scholar
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259. https://doi.org/10.1007/BF00308809
Article CAS PubMed Google Scholar
Chen X, Holtzman DM (2022) Emerging roles of innate and adaptive immunity in Alzheimer’s disease. Immunity 55:2236–2254. https://doi.org/10.1016/j.immuni.2022.10.016
Article CAS PubMed PubMed Central Google Scholar
Dai L, Shen Y (2021) Insights into T-cell dysfunction in Alzheimer’s disease. Aging Cell 20:e13511. https://doi.org/10.1111/acel.13511
Article CAS PubMed PubMed Central Google Scholar
Durack DT, Sumi SM, Klebanoff SJ (1979) Neurotoxicity of human eosinophils. Proc Natl Acad Sci U S A 76:1443–1447. https://doi.org/10.1073/pnas.76.3.1443
Article CAS PubMed PubMed Central Google Scholar
Fiala M, Lin J, Ringman J et al (2005) Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer’s disease patients. J Alzheimers Dis 7:221–232. https://doi.org/10.3233/jad-2005-7304. Discussion 255–262.
Article CAS PubMed Google Scholar
Franz M, Rodriguez H, Lopes C et al (2018) GeneMANIA update 2018. Nucleic Acids Res 46:W60–W64. https://doi.org/10.1093/nar/gky311
Article CAS PubMed PubMed Central Google Scholar
Gabbita SP, Johnson MF, Kobritz N et al (2015) Oral TNFalpha modulation alters neutrophil infiltration, improves cognition and diminishes tau and amyloid pathology in the 3xTgAD mouse model. PLoS ONE 10:e0137305. https://doi.org/10.1371/journal.pone.0137305
Article CAS PubMed PubMed Central Google Scholar
Giri M, Zhang M, Lü Y (2016) Genes associated with Alzheimer’s disease: an overview and current status. Clin Interv Aging 11:665–681. https://doi.org/10.2147/CIA.S105769
Article CAS PubMed PubMed Central Google Scholar
Gu X, Lai D, Liu S et al (2022) Hub genes, diagnostic model, and predicted drugs related to iron metabolism in Alzheimer’s disease. Frontiers in Aging Neurosci. https://doi.org/10.3389/fnagi.2022.949083
Gustavsson EK, Zhang D, Reynolds RH et al (2022) ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2. Bioinformatics 38:3844–3846. https://doi.org/10.1093/bioinformatics/btac409
Article CAS PubMed PubMed Central Google Scholar
Han L, Yuan Y, Zheng S et al (2014) The pan-cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes. Nat Commun 5:3963. https://doi.org/10.1038/ncomms4963
Article CAS PubMed Google Scholar
Haney MS, Palovics R, Munson CN et al (2024) APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia. Nature. https://doi.org/10.1038/s41586-024-07185-7
Article PubMed PubMed Central Google Scholar
Heneka MT, Carson MJ, El Khoury J et al (2015) Neuroinflammation in Alzheimer’s disease. Lancet Neurol 14:388–405. https://doi.org/10.1016/S1474-4422(15)70016-5
Article CAS PubMed PubMed Central Google Scholar
Hinz FI, Geschwind DH (2017) Molecular genetics of neurodegenerative dementias. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a023705
Article PubMed PubMed Central Google Scholar
Hu C, Li T, Xu Y et al (2023) Cell Marker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data. Nucleic Acids Res 51:D870–D876. https://doi.org/10.1093/nar/gkac947
Article CAS PubMed Google Scholar
Järemo P, Milovanovic M, Buller C et al (2013) Alzheimer’s disease and granulocyte density diversity. Eur J Clin Investig 43:545–548. https://doi.org/10.1111/eci.12072
Johansen A, Rosti RO, Musaev D et al (2016) Mutations in MBOAT7, encoding lysophosphatidylinositol acyltransferase I, lead to intellectual disability accompanied by epilepsy and autistic features. Am J Hum Genet 99:912–916. https://doi.org/10.1016/j.ajhg.2016.07.019
Article CAS PubMed PubMed Central Google Scholar
Jorfi M, Maaser-Hecker A, Tanzi RE (2023) The neuroimmune axis of Alzheimer’s disease. Genome Med 15:6. https://doi.org/10.1186/s13073-023-01155-w
Article CAS PubMed PubMed Central Google Scholar
King E, O’Brien JT, Donaghy P et al (2018) Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias. J Neurol Neurosurg Psychiatry 89:339–345. https://doi.org/10.1136/jnnp-2017-317134
Knopman DS, Amieva H, Petersen RC et al (2021) Alzheimer Disease Nat Rev Dis Primers 7:33. https://doi.org/10.1038/s41572-021-00269-y
Kölsch H, Lütjohann D, Jessen F et al (2009) RXRA gene variations influence Alzheimer’s disease risk and cholesterol metabolism. J Cell Mol Med 13:589–598. https://doi.org/10.1111/j.1582-4934.2009.00383.x
Article CAS PubMed PubMed Central Google Scholar
Kolykhalov IV, Androsova LV, Gavrilova SI (2022) Clinical and immunological effects of choline alfoscerate in the treatment of amnestic type mild cognitive impairment. Zh Nevrol Psikhiatr Im S S Korsakova 122:59–66. https://doi.org/10.17116/jnevro202212211259
Article CAS PubMed Google Scholar
Komers R, Diva U, Inrig JK et al (2020) Study design of the phase 3 sparsentan versus irbesartan (DUPLEX) study in patients with focal segmental glomerulosclerosis. Kidney Int Rep 5:494–502. https://doi.org/10.1016/j.ekir.2019.12.017
Article PubMed PubMed Central Google Scholar
Koran ME, Hohman TJ, Meda SA et al (2014) Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. J Alzheimers Dis 38:145–154. https://doi.org/10.3233/JAD-130989
Kunkle BW, Grenier-Boley B, Sims R et al (2019) Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. Nat Genet 51:414–430. https://doi.org/10.1038/s41588-019-0358-2
Article CAS PubMed PubMed Central Google Scholar
Lau SF, Cao H, Fu AKY et al (2020) Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease. Proc Natl Acad Sci U S A 117:25800–25809.
Comments (0)