REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage

Adlanmerini M, Nguyen HC, Krusen BM, Teng CW, Geisler CE, Peed LC, Carpenter BJ, Hayes MR, Lazar MA (2021) Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice. J Clin Investig 131:e140424

Article  CAS  PubMed  PubMed Central  Google Scholar 

Araujo B, Caridade-Silva R, Soares-Guedes C, Martins-Macedo J, Gomes ED, Monteiro S, Teixeira FG (2022) Neuroinflammation and Parkinson's disease-from neurodegeneration to therapeutic opportunities. Cells 11(18):2908

Brandebura AN, Paumier A, Onur TS, Allen NJ (2023) Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat Rev Neurosci 24:23–39

Article  CAS  PubMed  Google Scholar 

Breen DP, Vuono R, Nawarathna U, Fisher K, Shneerson JM, Reddy AB, Barker RA (2014) Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol 71:589–595

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Zhang DM, Feng X, Wang J, Qin YY, Zhang T, Huang Q, Sheng R, Chen Z, Li M, Qin ZH (2018) TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes. Neuropharmacology 131:377–388

Article  CAS  PubMed  Google Scholar 

Colombo E, Farina C (2016) Astrocytes: key regulators of neuroinflammation. Trends Immunol 37:608–620

Article  CAS  PubMed  Google Scholar 

Colwell CS (2021) Defining circadian disruption in neurodegenerative disorders. J Clin Invest 131(19):e148288

Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, Khakh BS (2022) Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science. 378:eadc9020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhauser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Diaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Gotz M, Gutierrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Perez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24:312–325

Article  CAS  PubMed  PubMed Central  Google Scholar 

Everett LJ, Lazar MA (2014) Nuclear receptor Rev-erbalpha: up, down, and all around. Trends Endocrinol Metab 25:586–592

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeno MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES (2019) Circadian clock protein Rev-erbalpha regulates neuroinflammation. Proc Natl Acad Sci USA 116:5102–5107

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J & Musiek ES (2020) REV-ERBalpha mediates complement expression and diurnal regulation of microglial synaptic phagocytosis, eLife. 9. https://doi.org/10.7554/eLife.58765

Guo DK, Zhu Y, Sun HY, Xu XY, Zhang S, Hao ZB, Wang GH, Mu CC, Ren HG (2019) Pharmacological activation of REV-ERBalpha represses LPS-induced microglial activation through the NF-kappaB pathway. Acta Pharmacol Sin 40:26–34

Article  PubMed  Google Scholar 

Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, Mouatt-Prigent A, Turmel H, Srinivasan A, Ruberg M, Evan GI, Agid Y, Hirsch EC (2000) Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson’s disease. Proc Natl Acad Sci U S A 97:2875–2880

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hastings MH, Brancaccio M, Gonzalez-Aponte MF, Herzog ED (2023) Circadian rhythms and astrocytes: the good, the bad, and the ugly. Ann Rev Neurosci 46:123–143

Article  CAS  PubMed  Google Scholar 

Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada K, Koyanagi S, Ohdo S (2013) A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson’s disease. NeuroMol Med 15:238–251

Article  CAS  Google Scholar 

Ikegami K, Refetoff S, Van Cauter E, Yoshimura T (2019) Interconnection between circadian clocks and thyroid function. Nat Rev Endocrinol 15:590–600

Article  PubMed  PubMed Central  Google Scholar 

Ishii T, Warabi E, Mann GE (2019) Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis. Free Radical Biol Med 133:169–178

Article  CAS  Google Scholar 

Koronowski KB, Sassone-Corsi P (2021) Communicating clocks shape circadian homeostasis. Science 371(6530):eabd0951

Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T (2022) The circadian clock protein Rev-erbalpha provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome. J Neuroinflammation 19:133

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lananna BV, Nadarajah CJ, Izumo M, Cedeno MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES (2018) Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1. Cell Rep 25(1–9):e5

Google Scholar 

Lee J, Kim DE, Griffin P, Sheehan PW, Kim DH, Musiek ES, Yoon SY (2020) Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease. Aging Cell 19:e13078

Article  CAS  PubMed  Google Scholar 

Lee HG, Wheeler MA, Quintana FJ (2022) Function and therapeutic value of astrocytes in neurological diseases. Nat Rev Drug Discovery 21:339–358

Article  CAS  PubMed  Google Scholar 

Lee J, Dimitry JM, Song JH, Son M, Sheehan PW, King MW, Travis Tabor G, Goo YA, Lazar MA, Petrucelli L, Musiek ES (2023) Microglial REV-ERBalpha regulates inflammation and lipid droplet formation to drive tauopathy in male mice. Nat Commun 14:5197

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leone MJ, Marpegan L, Bekinschtein TA, Costas MA, Golombek DA (2006) Suprachiasmatic astrocytes as an interface for immune-circadian signalling. J Neurosci Res 84:1521–1527

Article  CAS  PubMed  Google Scholar 

Liang P, Zhang X, Zhang Y, Wu Y, Song Y, Wang X, Chen T, Liu W, Peng B, Yin J, He F, Fan Y, Han S, He X (2023) Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy. Free Radical Biol Med 195:329–342

Article  CAS  Google Scholar 

Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46:957–967

Article  CAS  PubMed  Google Scholar 

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Munch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541:481–487

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKee CA, Lananna BV, Musiek ES (2020) Circadian regulation of astrocyte function: implications for Alzheimer’s disease. Cell Mole Life Sci : CMLS 77:1049–1058

Article  CAS  Google Scholar 

Park MW, Cha HW, Kim J, Kim JH, Yang H, Yoon S, Boonpraman N, Yi SS, Yoo ID, Moon JS (2021) NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases. Redox Biol 41:101947

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patani R, Hardingham GE, Liddelow SA (2023) Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration. Nat Rev Neurol 19:395–409

Article  CAS  PubMed  Google Scholar 

Roth RH, Ding JB (2020) From neurons to cognition: technologies for precise recording of neural activity underlying behavior. BME Front 2020:7190517

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