Arkell RS, Dickinson RJ, Squires M et al (2008) DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5. Cell Signal 20:836–843

Article  CAS  PubMed  Google Scholar 

Athanason AC, Nadav T, Cates-Gatto C et al (2023) Chronic ethanol alters adrenergic receptor gene expression and produces cognitive deficits in male mice. Neurobiol Stress 24:100542

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benito-León M, Gil-Redondo JC, Perez-Sen R et al (2022) BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells. Front Cell Dev Biol 10:1049566

Article  PubMed  PubMed Central  Google Scholar 

Carrillo J, Zafrilla MP, Marhuenda J (2019) Cognitive function and consumption of fruit and vegetable polyphenols in a young population: is there a relationship? Foods 8:507

Chandrasekhar A, Komirishetty P, Areti A et al (2021) Dual specificity phosphatases support axon plasticity and viability. Mol Neurobiol 58:391–407

Article  CAS  PubMed  Google Scholar 

Charlet K, Rosenthal A, Lohoff FW et al (2018) Imaging resilience and recovery in alcohol dependence. Addiction 113:1933–1950

Article  PubMed  PubMed Central  Google Scholar 

Chen HF, Chuang HC, Tan TH (2019a) Regulation of dual-specificity phosphatase (DUSP) ubiquitination and protein stability. Int J Mol Sci 20:2668

Chen HF, Chuang HC, Tan TH (2019b) Regulation of dual-specificity phosphatase (DUSP) ubiquitination and protein stability. Int J Mol Sci 20:2668

Chen X, Jia B, Araki Y et al (2022) Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation. Cell Res 32:914–930

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chotiner JK, Nielson J, Farris S et al (2010) Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem 17:117–129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colucci-D'Amato L, Speranza L, Volpicelli F (2020) Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer. Int J Mol Sci 21:7777

Guo YJ, Pan WW, Liu SB et al (2020) ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med 19:1997–2007

PubMed  PubMed Central  Google Scholar 

Hernández-Vázquez F, Reyes-Guzmán C, Méndez M (2018) Impact of a novel environment on alcohol-induced locomotor activity in Wistar rats. Alcohol 71:5–13

Article  PubMed  Google Scholar 

Hoppstädter J, Ammit AJ (2019) Role of dual-specificity phosphatase 1 in glucocorticoid-driven anti-inflammatory responses. Front Immunol 10:1446

Article  PubMed  PubMed Central  Google Scholar 

Hsu WC, Chen MY, Hsu SC et al (2018) DUSP6 mediates T cell receptor-engaged glycolysis and restrains T(FH) cell differentiation. Proc Natl Acad Sci U S A 115:E8027-e8036

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ilhan MN, Yapar D (2020) Alcohol consumption and alcohol policy. Turk J Med Sci 50:1197–1202

Article  PubMed  PubMed Central  Google Scholar 

Kanda Y, Mizuno A, Takasaki T et al (2021) Down-regulation of dual-specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2. Genes Cells 26:109–116

Article  CAS  PubMed  Google Scholar 

Kasai H, Fukuda M, Watanabe S et al (2010) Structural dynamics of dendritic spines in memory and cognition. Trends Neurosci 33:121–129

Article  CAS  PubMed  Google Scholar 

Lang R, Raffi FAM (2019a) Dual-specificity phosphatases in immunity and infection: an update. Int J Mol Sci 20:2710

Lang R, Raffi FAM (2019b) Dual-specificity phosphatases in immunity and infection: an update. Int J Mol Sci 20:2710

Le Berre AP (2019) Emotional processing and social cognition in alcohol use disorder. Neuropsychology 33:808–821

Article  PubMed  PubMed Central  Google Scholar 

Leal G, Comprido D, Duarte CB (2014) BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology 76:639–656

Article  CAS  PubMed  Google Scholar 

Li J, Wang H, Liu D et al (2023) CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice. Brain Behav Immun 110:60–79

Article  CAS  PubMed  Google Scholar 

Miningou Zobon NT, Jędrzejewska-Szmek J, Blackwell KT (2021) Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction. Elife 10:e64644

Mira RG, Tapia-Rojas C, Pérez MJ et al (2019) Alcohol impairs hippocampal function: from NMDA receptor synaptic transmission to mitochondrial function. Drug Alcohol Depend 205:107628

Article  CAS  PubMed  Google Scholar 

Moody TW (2019) Peptide receptors as cancer drug targets. Ann N Y Acad Sci 1455:141–148

Article  CAS  PubMed  PubMed Central  Google Scholar 

Motaghinejad M, Mashayekh R, Motevalian M et al (2021) The possible role of CREB-BDNF signaling pathway in neuroprotective effects of minocycline against alcohol-induced neurodegeneration: molecular and behavioral evidences. Fundam Clin Pharmacol 35:113–130

Article  CAS  PubMed  Google Scholar 

Pérez-Sen R, Queipo MJ, Gil-Redondo JC et al (2019) Dual-specificity phosphatase regulation in neurons and glial cells. Int J Mol Sci 20:1999

Qiao X, Sun M, Chen Y et al (2021) Ethanol-induced neuronal and cognitive/emotional impairments are accompanied by down-regulated NT3-TrkC-ERK in hippocampus. Alcohol Alcohol 56:220–229

Article  CAS  PubMed  Google Scholar 

Rosas M, Zaru A, Sabariego M et al (2014) Differential sensitivity of ethanol-elicited ERK phosphorylation in nucleus accumbens of Sardinian alcohol-preferring and -non preferring rats. Alcohol 48:471–476

Article  CAS  PubMed  Google Scholar 

Shao LL, Gao MM, Gong JX et al (2021) DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway. J Chem Neuroanat 118:102032

Article  CAS  PubMed  Google Scholar 

Socodato R, Henriques JF, Portugal CC et al (2020) Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. Sci Signal 13:eaba5754

Steven A, Friedrich M, Jank P et al (2020) What turns CREB on? And off? And why does it matter? Cell Mol Life Sci 77:4049–4067

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sugiura R, Satoh R, Takasaki T (2021) ERK: a double-edged sword in cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer. Cells 10:2509

Sun M, Zheng Q, Wang L et al (2024) Alcohol consumption during adolescence alters the cognitive function in adult male mice by persistently increasing levels of DUSP6. Mol Neurobiol 61:3161–3178

Article  CAS  PubMed  Google Scholar 

Swart PC, Currin CB, Russell VA et al (2017) Early ethanol exposure and vinpocetine treatment alter learning- and memory-related proteins in the rat hippocampus and prefrontal cortex. J Neurosci Res 95:1204–1215

Article  CAS  PubMed  Google Scholar 

Topiwala A, Ebmeier KP (2018) Effects of drinking on late-life brain and cognition. Evid Based Ment Health 21:12–15

Wang JQ, Mao L (2019) The ERK pathway: molecular mechanisms and treatment of depression. Mol Neurobiol 56:6197–6205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu C, Xiong Q, Tian X et al (2022) Alcohol exposure induces depressive and anxiety-like behaviors via activating ferroptosis in mice. Int J Mol Sci 23:13828

Yan Z, Rein B (2022) Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications. Mol Psychiatry 27:445–465

Article  PubMed  Google Scholar 

Zhang F, Tang B, Zhang Z et al (2019) DUSP6 inhibitor (E/Z)-BCI hydrochloride attenuates lipopolysaccharide-induced inflammatory responses in murine macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. Inflammation 42:672–681

Article  CAS  PubMed