Araújo B, Caridade-Silva R, Soares-Guedes C, Martins-Macedo J, Gomes ED, Monteiro S, Teixeira FG (2022) Neuroinflammation and Parkinson’s Disease—from neurodegeneration to Therapeutic opportunities. Cells 11(18):2908. https://doi.org/10.3390/cells11182908

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armstrong MJ, Okun MS (2020) Diagnosis and treatment of Parkinson Disease: A Review. JAMA 323(6):548. https://doi.org/10.1001/jama.2019.22360

Article  PubMed  Google Scholar 

Berg D, Lang AE, Postuma RB, Maetzler W, Deuschl G, Gasser T, Siderowf A et al (2013) Changing the Research Criteria for the Diagnosis of Parkinson’s Disease: Obstacles and Opportunities. The Lancet Neurology 12(5):514–524. https://doi.org/10.1016/S1474-4422(13)70047-4

Article  PubMed  Google Scholar 

Beyer M, Mallmann MR, Xue J, Staratschek-Jox A, Vorholt D, Krebs W, Sommer D et al (2012) High-resolution transcriptome of human macrophages. PLoS ONE 7(9):e45466. https://doi.org/10.1371/journal.pone.0045466

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bohlson SS, Silva R, Fonseca MI, Tenner AJ (2005) CD93 is rapidly shed from the Surface of Human myeloid cells and the Soluble form is detected in human plasma. J Immunol 175(2):1239–1247. https://doi.org/10.4049/jimmunol.175.2.1239

Article  CAS  PubMed  Google Scholar 

Bowden J, Smith GD (2015) Mendelian randomization with Invalid instruments: Effect Estimation and Bias Detection through Egger Regression. Int J Epidemiol 44(2):512–525. https://doi.org/10.1093/ije/dyv080

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Smith GD, Haycock PC (2016) Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304–314. https://doi.org/10.1002/gepi.21965

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Scott RA, Timpson NJ, Smith GD, Thompson SG (2015) Using published data in mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543–552. https://doi.org/10.1007/s10654-015-0011-z

Article  PubMed  PubMed Central  Google Scholar 

da Rocha Sobrinho HM, Saar Gomes R, da Silva DJ, Quixabeira VB, Joosten LA, de Barros Ribeiro, Cardoso C, Ribeiro-Dias F (2021) Toll-like Receptor 10 Controls TLR2-induced Cytokine Production in Monocytes from Patients with Parkinson’s Disease. Journal of Neuroscience Research 99(10):2511–2524. https://doi.org/10.1002/jnr.24916

Article  CAS  PubMed  Google Scholar 

Dalakas MC, Alexopoulos H, Peter JS (2020) Complement in neurological disorders and emerging complement-targeted therapeutics. Nat Reviews Neurol 16(11):601–617. https://doi.org/10.1038/s41582-020-0400-0

Article  Google Scholar 

Davey Smith G (2003) Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of Disease?*. Int J Epidemiol 32(1):1–22. https://doi.org/10.1093/ije/dyg070

Article  Google Scholar 

Dheilly E, Battistello E, Katanayeva N, Sungalee S, Michaux J, Duns G, Wehrle S et al (2020) Cathepsin S Regulates Antigen Processing and T Cell activity in Non-hodgkin Lymphoma. Cancer Cell 37(5):674-689e12. https://doi.org/10.1016/j.ccell.2020.03.016

Article  CAS  PubMed  Google Scholar 

Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Mohamed O, Portugal B et al (2022) Dairy intake and Parkinson’s Disease: a mendelian randomization study. Mov Disord 37(4):857–864. https://doi.org/10.1002/mds.28902

Article  CAS  PubMed  Google Scholar 

Domínguez-Baleón C, Ong J-S, Scherzer CR, Rentería ME, Dong X (2021) Understanding the effect of smoking and drinking behavior on Parkinson’s disease risk: a mendelian randomization study. Sci Rep 11:13980. https://doi.org/10.1038/s41598-021-93105-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong-Chen X, Yong C, Yang X, Chen-Yu S, Li-Hua P (2022) Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions. Sig Transduct Target Ther 8(1):73. https://doi.org/10.1038/s41392-023-01353-3

Article  Google Scholar 

Dzamko N, Gysbers A, Perera G, Bahar A, Shankar A, Gao J, Fu YH (2017) Toll-like receptor 2 is increased in neurons in Parkinson’s Disease Brain and May Contribute to Alpha-Synuclein Pathology. Acta Neuropathol 133(2):303–319. https://doi.org/10.1007/s00401-016-1648-8

Article  CAS  PubMed  Google Scholar 

Flynn CM, Garbers Y, Lokau J, Wesch D, Schulte DM, Laudes M, Lieb W, Aparicio-Siegmund S (2019) Activation of toll-like receptor 2 (TLR2) induces Interleukin-6 trans-signaling. Sci Rep 9(May):7306. https://doi.org/10.1038/s41598-019-43617-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gan-Or Z, Wood NW (2021) Mendelian randomization studies: a path to Better Understand sex and gender differences in Parkinson’s Disease? Mov Disord 36(10):2220–2222. https://doi.org/10.1002/mds.28765

Article  PubMed  Google Scholar 

Goldknopf IL, Sheta EA, Bryson J, Folsom B, Wilson C, Duty J, Yen AA, Appel SH (2006) Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson’s disease. Biochem Biophys Res Commun 342(4):1034–1039. https://doi.org/10.1016/j.bbrc.2006.02.051

Article  CAS  PubMed  Google Scholar 

Gordon R, Anantharam V, Anumantha G, Kanthasamy, and Arthi Kanthasamy, (2012) Proteolytic Activation of Proapoptotic Kinase Protein Kinase Cδ by Tumor necrosis factor α death receptor signaling in dopaminergic neurons during Neuroinflammation. J Neuroinflamm 9(8):1831. https://doi.org/10.1186/1742-2094-9-82

Article  CAS  Google Scholar 

Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C et al (2016) Protein kinase Cδ upregulation in Microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson’s Disease. Neurobiol Dis 93(September):96–114. https://doi.org/10.1016/j.nbd.2016.04.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffiths MR, Botto M, Morgan BP, Neal JW, Gasque P (2018) CD93 regulates central nervous system inflammation in two mouse models of Autoimmune Encephalomyelitis. Immunology 155(3):346–355. https://doi.org/10.1111/imm.12974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Z, Eils R (2016) Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics 32(18):2847–2849. https://doi.org/10.1093/bioinformatics/btw313

Article  CAS  PubMed  Google Scholar 

Gustavsson EK, Zhang D, Reynolds RH, Garcia-Ruiz S (2022) Ggtranscript: an R Package for the visualization and interpretation of transcript isoforms using Ggplot2. Bioinformatics 38(15):3844–3846. https://doi.org/10.1093/bioinformatics/btac409

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hammond TR, Marsh SE, Stevens B (2019) Immune signaling in neurodegeneration. Immun 50(4):955–974. https://doi.org/10.1016/j.immuni.2019.03.016

Article  CAS  Google Scholar 

Hänzelmann S, Castelo R, Guinney J (2013) GSVA: Gene Set Variation Analysis for Microarray and RNA-Seq Data. BMC Bioinformatics 14(January):7. https://doi.org/10.1186/1471-2105-14-7

Article  PubMed  PubMed Central  Google Scholar 

Hartwig FP, Smith GD, Bowden J (2017) Robust inference in summary data mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46(6):1985–1998. https://doi.org/10.1093/ije/dyx102

Article  PubMed  PubMed Central  Google Scholar 

He Y, Zhao J, Dong H, Zhang X, Duan Y, Ma Y, Yu M, Fei J, Huang F (2023) TLR2 Deficiency is Beneficial at the late phase in MPTP-Induced Parkinson’ Disease mice. Life Sci 333(November):122171. https://doi.org/10.1016/j.lfs.2023.122171

Article  CAS  PubMed