Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification

Gustavsson A, Norton N, Fast T, Frölich L, Georges J, Holzapfel D, et al. Global estimates on the number of persons across the Alzheimer’s disease continuum. Alzheimer’s & Dementia. 2023;19:658–70. https://doi.org/10.1002/alz.12694.

Article  Google Scholar 

World Alzheimer Report; 2023. https://www.alzint.org/what-we-do/research/world-alzheimer-report/

Soto C, Pritzkow S. Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases. Nat Neurosci. 2018;21:1332–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nat Neurosci. 2018;21:1300–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

LaFerla FM, Green KN, Oddo S. Intracellular amyloid-β in Alzheimer’s disease. Nat Rev Neurosci. 2007;8:499–509.

Article  CAS  PubMed  Google Scholar 

Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, et al. Structure-based classification of tauopathies. Nature. 2021;598:359–63.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, et al. α-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol. 2002;4:160–4.

Article  CAS  PubMed  Google Scholar 

Silveira JR, Raymond GJ, Hughson AG, Race RE, Sim VL, Hayes SF, et al. The most infectious prion protein particles. Nature. 2005;437:257–61.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science. 2008;319:1668–72. https://doi.org/10.1126/science.1154584.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Iadanza MG, Jackson MP, Hewitt EW, Ranson NA, Radford SE. A new era for understanding amyloid structures and disease. Nat Rev Mol Cell Biol. 2018;19:755–73.

Article  CAS  PubMed  Google Scholar 

Bemporad F, Chiti F. Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships. Chem Biol. 2012;19:315–27. https://doi.org/10.1016/j.chembiol.2012.02.003.

Article  CAS  PubMed  Google Scholar 

Serpell LC, Berriman J, Jakes R, Goedert M, Crowther RA. Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation. Proc Natl Acad Sci USA. 2000;97:4897–902. https://doi.org/10.1073/pnas.97.9.4897.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Koike H, Iguchi Y, Sahashi K, Katsuno M. Significance of oligomeric and fibrillar species in amyloidosis: insights into pathophysiology and treatment. Molecules. 2021;26:5091.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajamohamedsait HB, Sigurdsson EM. Histological Staining of amyloid and pre-amyloid peptides and proteins in mouse tissue. Methods Mol Biol. 2012;849:411–24. https://doi.org/10.1007/978-1-61779-551-0_28.

Article  CAS  PubMed  Google Scholar 

Villemagne VL, Doré V, Burnham SC, Masters CL, Rowe CC. Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions. Nat Rev Neurol. 2018;14:225–36.

Article  CAS  PubMed  Google Scholar 

Nabers A, Perna L, Lange J, Mons U, Schartner J, Güldenhaupt J, et al. Amyloid blood biomarker detects Alzheimer’s disease. EMBO Mol Med. 2018;10: e8763. https://doi.org/10.15252/emmm.201708763.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simonsen AH, Herukka S-K, Andreasen N, Baldeiras I, Bjerke M, Blennow K, et al. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. Alzheimer’s & Dementia. 2017;13:274–84. https://doi.org/10.1016/j.jalz.2016.09.008.

Article  Google Scholar 

Alzghool OM, Dongen G, Giessen E, Schoonmade L, Beaino W. α-Synuclein radiotracer development and in vivo imaging: recent advancements and new perspectives. Mov Disord. 2022;37:936–48. https://doi.org/10.1002/mds.28984.

Article  PubMed  PubMed Central  Google Scholar 

Vaneyck J, Yousif TA, Segers-Nolten I, Blum C, Claessens MMAE. Quantitative seed amplification assay: a proof-of-principle study. J Phys Chem B. 2023;127:1735–43. https://doi.org/10.1021/acs.jpcb.2c08326.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siderowf A, Concha-Marambio L, Lafontant D-E, Farris CM, Ma Y, Urenia PA, et al. Assessment of heterogeneity among participants in the Parkinson’s Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study. The Lancet Neurology. 2023;22:407–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia. 2011;7:263–9. https://doi.org/10.1016/j.jalz.2011.03.005.

Article  Google Scholar 

Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia. 2018;14:535–62. https://doi.org/10.1016/j.jalz.2018.02.018.

Article  Google Scholar 

Harada R, Okamura N, Furumoto S, Yanai K. Imaging protein misfolding in the brain using β-sheet ligands. Front Neurosci. 2018;12:585. https://doi.org/10.3389/fnins.2018.00585/full.

Article  PubMed  PubMed Central  Google Scholar 

Leuzy A, Chiotis K, Lemoine L, Gillberg P-G, Almkvist O, Rodriguez-Vieitez E, et al. Tau PET imaging in neurodegenerative tauopathies—still a challenge. Mol Psychiatry. 2019;24:1112–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knight AC, Morrone CD, Varlow C, Yu WH, McQuade P, Vasdev N. Head-to-head comparison of Tau-PET radioligands for imaging TDP-43 in post-mortem ALS brain. Mol Imag Biol. 2023;25:513–27. https://doi.org/10.1007/s11307-022-01779-1.

Article  CAS  Google Scholar 

Dahal E, Ghammraoui B, Ye M, Smith JC, Badano A. Label-free X-ray estimation of brain amyloid burden. Sci Rep. 2020;10:20505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dahal E, Ghammraoui B, Badano A. Feasibility of a label-free X-ray method to estimate brain amyloid load in small animals. J Neurosci Methods. 2020;343: 108822.

Article  CAS  PubMed  Google Scholar 

Ghammraoui B, Badano A. Identification of amyloid plaques in the brain using an x-ray photon-counting strip detector. PLoS ONE. 2020;15: e0228720. https://doi.org/10.1371/journal.pone.0228720.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breedlove S, Crentsil J, Dahal E, Badano A. Small-angle X-ray scattering characterization of a β-amyloid model in phantoms. BMC Res Notes. 2020;13:128. https://doi.org/10.1186/s13104-020-04969-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dahal E, Ghammraoui B, Badano A. Characterization of materials embedded in thick objects using spectral small-angle x-ray scattering. J Phys D Appl Phys. 2020;53: 245302. https://doi.org/10.1088/1361-6463/ab8248.

Article  ADS  CAS  Google Scholar 

Choi M, Dahal E, Badano A. Feasibility of imaging amyloid in the brain using small-angle x-ray scattering. Biomed Phys Eng Express. 2021;7: 015008. https://doi.org/10.1088/2057-1976/ab501c.

Article  Google Scholar 

Ke PC, Zhou R, Serpell LC, Riek R, Knowles TPJ, Lashuel HA, et al. Half a century of amyloids: past, present and future. Chem Soc Rev. 2020;49:5473–509.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, et al. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell. 2011;144:67–78.

Article  CAS  PubMed  Google Scholar 

Goldschmidt L, Teng PK, Riek R, Eisenberg D. Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci USA. 2010;107:3487–92. https://doi.org/10.1073/pnas.0915166107.

Article  ADS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif