Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin. 2021;71:209–49.

Article  Google Scholar 

Hess KR, Varadhachary GR, Taylor SH, Wei W, Raber MN, Lenzi R, et al. Metastatic patterns in adenocarcinoma. Cancer. 2006;106:1624–33.

Article  PubMed  Google Scholar 

Leone BA, Vallejo CT, Romero AO, Machiavelli MR, Pérez JE, Leone J, et al. Prognostic impact of metastatic pattern in stage IV breast cancer at initial diagnosis. Breast Cancer Res Treat. 2017;161:537–48.

Article  CAS  PubMed  Google Scholar 

Zhang H, Zhu W, Biskup E, Yang W, Yang Z, Wang H, et al. Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: a systematic review of the real world data. J Bone Oncol. 2018;11:38–50.

Article  PubMed  PubMed Central  Google Scholar 

Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006;12:6243s-s6249.

Article  PubMed  Google Scholar 

Zhang XH-F, Giuliano M, Trivedi MV, Schiff R, Osborne CK. Metastasis dormancy in estrogen receptor-positive breast cancer. Clin Cancer Res. 2013;19:6389–97.

Article  CAS  PubMed  Google Scholar 

Shi D, Bai J, Chen Y, Wang X, Zhang Y, Liu H. Predicting the incidence and prognosis of bone metastatic breast cancer: a SEER-based observational study. BioMed Res Int. 2020;2020:1–9.

Google Scholar 

Xiao W, Zheng S, Yang A, Zhang X, Zou Y, Tang H, et al. Breast cancer subtypes and the risk of distant metastasis at initial diagnosis: a population-based study. CMAR. 2018;10:5329–38.

Article  CAS  Google Scholar 

Pulido C, Vendrell I, Ferreira AR, Casimiro S, Mansinho A, Alho I, et al. Bone metastasis risk factors in breast cancer. ecancer. 2017. http://www.ecancer.org/journal/11/full/715-bone-metastasis-risk-factors-in-breast-cancer.php. Accessed 8 Feb 2023.

Deng J, Zhang D, Zhang W, Li J. Construction and validation of new nomograms to predict risk and prognostic factors of breast cancer bone metastasis in Asian females: a population-based retrospective study. IJGM. 2021;14:8881–902.

Article  Google Scholar 

Jiang Z, Wang H, Wang S, Wang S, Wang T, Wang X, et al. Chinese expert consensus statement on the clinical diagnosis and treatment of breast cancer bone metastasis and bone related disease. Transl Breast Cancer Res. 2021;2:2–2.

Article  Google Scholar 

Yang M, Liu C, Yu X. Skeletal-related adverse events during bone metastasis of breast cancer: current status. Discov Med. 2019;27:211–20.

PubMed  Google Scholar 

Tahara RK, Brewer TM, Theriault RL, Ueno NT. Bone metastasis of breast cancer. Adv Exp Med Biol. 2019;1152:105–29.

Article  CAS  PubMed  Google Scholar 

Cardoso F, Paluch-Shimon S, Senkus E, Curigliano G, Aapro MS, André F, et al. 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5). Ann Oncol. 2020;31:1623–49.

Article  CAS  PubMed  Google Scholar 

Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, et al. Breast cancer, version 3.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2022;20:691–722.

Article  PubMed  Google Scholar 

Satcher RL, Zhang XH-F. Evolving cancer-niche interactions and therapeutic targets during bone metastasis. Nat Rev Cancer. 2022;22:85–101.

Article  CAS  PubMed  Google Scholar 

Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE, et al. IL-1 drives breast cancer growth and bone metastasis in vivo. Oncotarget. 2016;7:75571–84.

Article  PubMed  PubMed Central  Google Scholar 

Hannafon BN, Sebastiani P, de las Morenas A, Lu J, Rosenberg CL. Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res. 2011;13:R24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ke K, Sul O-J, Rajasekaran M, Choi H-S. MicroRNA-183 increases osteoclastogenesis by repressing heme oxygenase-1. Bone. 2015;81:237–46.

Article  CAS  PubMed  Google Scholar 

Yuan X, Qian N, Ling S, Li Y, Sun W, Li J, et al. Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells. Theranostics. 2021;11:1429–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014;25:501–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Epstein DM. Special delivery: microRNA-200–containing extracellular vesicles provide metastatic message to distal tumor cells. J Clin Invest. 2014;124:5107–8.

Article  PubMed  PubMed Central  Google Scholar 

Puppo M, Jaafar M, Diaz J-J, Marcel V, Clézardin P. MiRNAs and snoRNAs in bone metastasis: functional roles and clinical potential. Cancers. 2022;15:242.

Article  PubMed  PubMed Central  Google Scholar 

Hoshino A, Costa-Silva B, Shen T-L, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang XH-F, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, et al. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell. 2009;16:67–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, et al. Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1. Nat Cell Biol. 2017;19:1274–85.

Article  CAS  PubMed  Google Scholar 

Zhao C, Cai X, Wang Y, Wang D, Wang T, Gong H, et al. NAT1 promotes osteolytic metastasis in luminal breast cancer by regulating the bone metastatic niche via NF-κB/IL-1B signaling pathway. Am J Cancer Res. 2020;10:2464–79.

CAS  PubMed  PubMed Central  Google Scholar 

Wu Q, Tian P, He D, Jia Z, He Y, Luo W, et al. SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches. Cell Res. 2023. https://www.nature.com/articles/s41422-023-00810-6. Accessed 13 May 2023.

Zhang XH-F, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013;154:1060–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Price TT, Burness ML, Sivan A, Warner MJ, Cheng R, Lee CH, et al. Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. Sci Transl Med. 2016. https://doi.org/10.1126/scitranslmed.aad4059.

Article  PubMed  PubMed Central  Google Scholar 

Allocca G, Hughes R, Wang N, Brown HK, Ottewell PD, Brown NJ, et al. The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo. J Bone Oncol. 2019;17: 100244.

Article  PubMed  PubMed Central  Google Scholar 

Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, et al. The perivascular niche regulates breast tumour dormancy. Nat Cell Biol. 2013;15:807–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sandiford OA, Donnelly RJ, El-Far MH, Burgmeyer LM, Sinha G, Pamarthi SH, et al. Mesenchymal stem cell-secreted extracellular vesicles instruct stepwise dedifferentiation of breast cancer cells into dormancy at the bone marrow perivascular region. Can Res. 2021;81:1567–82.

Article  CAS  Google Scholar 

Bliss SA, Sinha G, Sandiford OA, Williams LM, Engelberth DJ, Guiro K, et al. Mesenchymal stem cell-derived exosomes stimulate cycling quiescence and early breast cancer dormancy in bone marrow. Can Res. 2016;76:5832–44.

Article  CAS  Google Scholar 

Clements ME, Johnson RW. Breast cancer dormancy in bone. Curr Osteoporos Rep. 2019;17:353–61.

Article  PubMed  PubMed Central  Google Scholar 

Phan TG, Croucher PI. The dormant cancer cell life cycle. Nat Rev Cancer. 2020;20:398–411.

Article  CAS  PubMed  Google Scholar 

Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L, et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 2015;27:193–210.

Article  PubMed  PubMed Central  Google Scholar 

Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006;6:729–34.

Article  CAS  PubMed  Google Scholar 

Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest. 1996;98:1544–9.

Article  CAS