Biomembrane-Derived vesicles for targeted cancer Therapies: Novel treatment avenues from Cells, Bacteria, and extracellular sources

AAI

antigen-antibody integrator

APRIL

a proliferating inducing ligand

ASPIRE

antigen self-presentation and immunosuppression reversal

aPD-L1

antibody anti-PD-L1

BAFF

B-cell activating factor

BCMA

B cell maturation antigen

BPQD

black phosphorus quantum dot

BMV

bacteria-derived membrane vesicle

CAR-T

chimeric antigen receptor T-cell

CDK1

cyclin-dependent kinase 1

CCMV

cancer cell membranes derived vesicle

CCNV

cancer cell nanovesicle

CMCN

cell membrane-coated nanosystem

CMV

cancer cell-platelet fusion membrane vesicle

CTC

circulating tumor cell

cyclic GMP-AMP

cyclic guanosine monophosphate-adenosine monophosphate

DLS

dynamic light scattering

DMV

double membrane vesicle

DNMTi

DNA methyltransferase inhibitor

EE

encapsulation efficiency

ENV

exosome-like nanovesicle

EPR

enhanced permeation and retention

FDA

food and drug administration

GM-CSF

granulocyte-macrophage colony-stimulating factor

HCC

hepatocellular carcinoma

HUVEC

human umbilical vascular endothelial cell

ICD

immunogenic cell death

IMV

inner membrane vesicle

ITIM

immunoreceptor tyrosine-based inhibitory motif

MHC-I

major histocompatibility complex class I

MPLA

monophosphoryl lipid A

OMV

outer membrane vesicle

O-TPNV

TIGIT-expressing cell membrane and platelet cell membrane fusion nanovesicles loaded with OXA

OVA

model antigen ovalbumin

PAMP

pathogen-associated molecular pattern

PBS

phosphate-buffered saline

PD-1

programmed cell death protein 1

PD-L1

programmed death-ligand 1

poly-IC

polyinosinic:polycytidylic acid

RGD

arginine-glycine-aspartic acid

RMNV

nanovesicle derived from red blood cell

ROS

reactive oxygen species

siRNA

small interfering RNA

TAA

tumor-associated antigen

TACI

transmembrane activator and calcium modulator and cyclophilin ligand

TEM

transmission electron microscopy

TGF-β

transforming growth factor-beta

TIGIT

immunoreceptor with immunoglobulin and ITIM domain

TME

tumor microenvironment

TNBC

triple-negative breast cancer

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