The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review

Simeone TA, Donevan SD, Rho JM. Molecular biology and ontogeny of gamma-aminobutyric acid (GABA) receptors in the mammalian central nervous system. J Child Neurol. 2003;18:39–48 (discussion 49).

Article  PubMed  Google Scholar 

Ramamoorthi K, Lin Y. The contribution of GABAergic dysfunction to neurodevelopmental disorders. Trends Mol Med. 2011;17:452–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korpi ER, Sinkkonen ST. GABA(A) receptor subtypes as targets for neuropsychiatric drug development. Pharmacol Ther. 2006;109:12–32.

Article  CAS  PubMed  Google Scholar 

Bettler B, Kaupmann K, Mosbacher J, Gassmann M. Molecular structure and physiological functions of GABA(B) receptors. Physiol Rev. 2004;84:835–67.

Article  CAS  PubMed  Google Scholar 

Nutt D. GABAA receptors: subtypes, regional distribution, and function. J Clin Sleep Med. 2006;2(2):S7-11.

Article  PubMed  Google Scholar 

Whiting PJ. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov Today. 2003;8:445–50.

Article  CAS  PubMed  Google Scholar 

Antkowiak B, Kirschfeld K. Neural mechanisms of anaesthesia [in German]. Anasthesiol Intensivmed. 2000;35:731–43.

Article  CAS  Google Scholar 

Collins JG, Kendig JJ, Mason P. Anesthetic actions within the spinal cord: contributions to the state of general anaesthesia. Trends Neurosci. 1995;18:549–53.

Article  CAS  PubMed  Google Scholar 

McGaugh JL, Izquierdo I. The contribution of pharmacology to research on the mechanisms of memory formation. Trends Pharmacol Sci. 2000;21:208–10.

Article  CAS  PubMed  Google Scholar 

McKernan RM, Rosahl TW, Reynolds DS, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat Neurosci. 2000;3:587–92.

Article  CAS  PubMed  Google Scholar 

Low K, Crestani F, Keist R, et al. Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 2000;290:131–4.

Article  CAS  PubMed  Google Scholar 

Chen K, Li HZ, Ye N, Zhang J, Wang JJ. Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro. Brain Res Bull. 2005;67(4):310–8.

Article  CAS  PubMed  Google Scholar 

Dimitrijevic N, Dzitoyeva S, Satta R, et al. Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB). Eur J Pharmacol. 2005;519(3):246–52.

Article  CAS  PubMed  Google Scholar 

Dzitoyeva S, Dimitrijevic N, Manev H. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci USA. 2003;100(9):5485–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manev H, Dimitrijevic N. Drosophila model for in vivo pharmacological analgesia research. Eur J Pharmacol. 2004;491(2–3):207–8.

Article  CAS  PubMed  Google Scholar 

Brogden RN, Speight TM, Avery GS. Baclofen: a preliminary report of its pharmacological properties and therapeutic efficacy in spasticity. Drugs. 1974;8(1):1–14.

Article  CAS  PubMed  Google Scholar 

Alkire MT, Hudetz AG, Tononi G. Consciousness and anesthesia. Science. 2008;322:876–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature. 1994;367:607–14.

Article  CAS  PubMed  Google Scholar 

Sanna E, Garau F, Harris RA. Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anaesthetics propofol and pentobarbital. Mol Pharmacol. 1995;47:213–7.

CAS  PubMed  Google Scholar 

Jones MV, Harrison NL, Pritchett DB, Hales TG. Modulation of the GABAA receptor by propofol is independent of the gamma subunit. J Pharmacol Exp Ther. 1995;274:962–8.

CAS  PubMed  Google Scholar 

Lam DW, Reynolds JN. Modulatory and direct effects of propofol on recombinant GABAA receptors expressed in xenopus oocytes: influence of alpha- and gamma2-subunits. Brain Res. 1998;784:179–87.

Article  CAS  PubMed  Google Scholar 

Sanna E, Murgia A, Casula A, Biggio G. Differential subunit dependence of the actions of the general anaesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes. Mol Pharmacol. 1997;51:484–90.

CAS  PubMed  Google Scholar 

Kay B, Rolly G. I.C.I. 35868, a new intravenous induction agent. Acta Anaesthesiol Belg. 1977;28:303–16.

CAS  PubMed  Google Scholar 

Chen S, Rex D. Registered nurse-administered propofol sedation for endoscopy. Aliment Pharmacol Ther. 2004;19(147):55.

CAS  Google Scholar 

Ansley DM, Raedschelders K, Choi PT, et al. Propofol cardioprotection for on-pump aortocoronary bypass surgery in patients with type 2 diabetes mellitus (PRO-TECT II): a phase 2 randomized-controlled trial. Can J Anesth. 2016;63:442–53.

Article  PubMed  Google Scholar 

De Cosmo G, Cancelli I, Adduci A, et al. Changes in the hemodynamics during isoflurane and propofol anaesthesia: a comparative study. Neurol Res. 2005;27:433–5.

Article  PubMed  Google Scholar 

Johnston A, Steiner L, Chatfield D, et al. Effects of propofol on cerebral oxygenation and metabolism after head injury. Br J Anaesth. 2003;91(6):781–6.

Article  CAS  PubMed  Google Scholar 

Absalom AR, Struys M. An overview of TCI and TIVA. Ghent: Academia Press; 2005.

Google Scholar 

Aglio L, Lekowski R, Urman R. Essential clinical anaesthesia review. Cambridge: Cambridge University Press; 2015.

Google Scholar 

Russell D, Wilkes MP, Hunter SC, et al. Manual compared with target-controlled infusion of propofol. Br J Anaesth. 1995;75:562–6.

Article  CAS  PubMed  Google Scholar 

Absalom A, Kenny G. Closed-loop control of propofol anaesthesia using bispectral index: performance assessment in patients receiving computer-controlled propofol and manually controlled remifentanil infusions for minor surgery. B J Anaesth. 2003;90(6):737–41.

Article  CAS  Google Scholar 

Leslie K, Clavisi O, Hargrove J. Target-controlled infusion versus manually-controlled infusion of propofol for general anaesthesia or sedation in adults. Cochrane Database Syst Rev. 2008;3:CD006059.

Google Scholar 

Enlund M, Berglund A, Enlund A, et al. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. EClinicalMedicine. 2023;60:102037. https://doi.org/10.1016/j.eclinm.2023.102037. (Published 2023 Jun 9).

Article  PubMed  PubMed Central  Google Scholar 

Cao SJ, Zhang Y, Zhang YX, et al. Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial. Br J Anaesth. 2023;131(2):266–75. https://doi.org/10.1016/j.bja.2023.01.023.

Article  CAS  PubMed  Google Scholar 

Gu L, Pan X, Wang C, Wang L. The benefits of propofol on cancer treatment: decipher its modulation code to immunocytes. Front Pharmacol. 2022;13: 919636.

Comments (0)

No login
gif