Research progress of ankyrin repeat domain 1 protein: an updated review

Kojic S, Radojkovic D, Faulkner G. Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease. Crit Rev Clin Lab Sci. 2011;48(5–6):269–94.

Article  CAS  PubMed  Google Scholar 

Ling SSM, Chen YT, Wang J, Richards AM, Liew OW. Ankyrin repeat domain 1 protein: a functionally pleiotropic protein with cardiac biomarker potential. Int J Mol Sci. 2017;18(7):1362. https://doi.org/10.3390/ijms18071362.

Article  PubMed  PubMed Central  Google Scholar 

Chu W, Burns DK, Swerlick RA, Presky DH. Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells. J Biol Chem. 1995;270(17):10236–45.

Article  CAS  PubMed  Google Scholar 

Jeyaseelan R, Poizat C, Baker RK, Abdishoo S, Isterabadi LB, Lyons GE, et al. A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes. J Biol Chem. 1997;272(36):22800–8.

Article  CAS  PubMed  Google Scholar 

Kuo H, Chen J, Ruiz-Lozano P, Zou Y, Nemer M, Chien KR. Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development. 1999;126(19):4223–34.

Article  CAS  PubMed  Google Scholar 

Ihara Y, Suzuki YJ, Kitta K, Jones LR, Ikeda T. Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin. Cell Calcium. 2002;32(1):21–9.

Article  CAS  PubMed  Google Scholar 

Chen B, Zhong L, Roush SF, Pentassuglia L, Peng X, Samaras S, et al. Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy. PLoS ONE. 2012;7(4): e35743.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin P, Tong C. LncRNA RGMB-AS1 up-regulates ANKRD1 through competitively sponging miR-3614-5p to promote OSA cell proliferation and invasion. Arch Med Res. 2022;53(2):131–7.

Article  CAS  PubMed  Google Scholar 

Baumeister A, Arber S, Caroni P. Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997;139(5):1231–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bin L, Li X, Richers B, Streib JE, Hu JW, Taylor P, et al. Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: a potential role in eczema herpeticum. J Allergy Clin Immunol. 2018;141(6):2085-93 e1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aihara Y, Kurabayashi M, Saito Y, Ohyama Y, Tanaka T, Takeda S, et al. Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter. Hypertension. 2000;36(1):48–53.

Article  CAS  PubMed  Google Scholar 

Jimenez AP, Traum A, Boettger T, Hackstein H, Richter AM, Dammann RH. The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth. Oncotarget. 2017;8(51):88437–52.

Article  PubMed  PubMed Central  Google Scholar 

Hui B, Ji H, Xu Y, Wang J, Ma Z, Zhang C, et al. RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4. Cell Death Dis. 2019;10(3):207.

Article  PubMed  PubMed Central  Google Scholar 

Xu X, Zhong D, Wang X, Luo F, Zheng X, Feng T, et al. Pan-cancer integrated analysis of ANKRD1 expression, prognostic value, and potential implications in cancer. Sci Rep. 2024;14(1):5268.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Srivastava RK, Elmets CA, Afaq F, Athar M. Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein. Biochem Biophys Res Commun. 2013;438(4):607–12.

Article  CAS  PubMed  Google Scholar 

Mannaerts I, Leite SB, Verhulst S, Claerhout S, Eysackers N, Thoen LF, et al. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol. 2015;63(3):679–88.

Article  CAS  PubMed  Google Scholar 

Takaguri A, Kubo T, Mori M, Satoh K. The protective role of YAP1 on ER stress-induced cell death in vascular smooth muscle cells. Eur J Pharmacol. 2017;815:470–7.

Article  CAS  PubMed  Google Scholar 

Xie R, Yuan S, Hu G, Zhan J, Jin K, Tang Y, et al. Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts. Mol Ther. 2024;32(5):1578–1594. https://doi.org/10.1016/j.ymthe.2024.03.018.

Article  PubMed  PubMed Central  Google Scholar 

Kanai H, Tanaka T, Aihara Y, Takeda S, Kawabata M, Miyazono K, et al. Transforming growth factor-beta/smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells. Circ Res. 2001;88(1):30–6.

Article  CAS  PubMed  Google Scholar 

Shin CH, Rossi M, Anerillas C, Martindale JL, Yang X, Ji E, et al. Increased ANKRD1 levels in early senescence mediated by RBMS1-elicited ANKRD1 mRNA stabilization. Mol Cell Biol. 2024;44(5):194–208.

Article  CAS  PubMed  Google Scholar 

Lun AS, Chen J, Lange S. Probing muscle ankyrin-repeat protein (MARP) structure and function. Anat Rec (Hoboken). 2014;297(9):1615–29.

Article  CAS  PubMed  Google Scholar 

Yura Y, Amano M, Takefuji M, Bando T, Suzuki K, Kato K, et al. Focused proteomics revealed a novel Rho-kinase signaling pathway in the heart. Cell Struct Funct. 2016;41(2):105–20.

Article  CAS  PubMed  Google Scholar 

Samaras SE, Chen B, Koch SR, Sawyer DB, Lim CC, Davidson JM. 26S proteasome regulation of Ankrd1/CARP in adult rat ventricular myocytes and human microvascular endothelial cells. Biochem Biophys Res Commun. 2012;425(4):830–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badi I, Cinquetti R, Frascoli M, Parolini C, Chiesa G, Taramelli R, et al. Intracellular ANKRD1 protein levels are regulated by 26S proteasome-mediated degradation. FEBS Lett. 2009;583(15):2486–92.

Article  CAS  PubMed  Google Scholar 

Laure L, Daniele N, Suel L, Marchand S, Aubert S, Bourg N, et al. A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-kappaB pathway in skeletal muscle. FEBS J. 2010;277(20):4322–37.

Article  CAS  PubMed  Google Scholar 

Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, et al. The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of Titin filament-based stress response molecules. J Mol Biol. 2003;333(5):951–64.

Article  CAS  PubMed  Google Scholar 

Samaras SE, Shi Y, Davidson JM. CARP: fishing for novel mechanisms of neovascularization. J Investig Dermatol Symp Proc. 2006;11(1):124–31.

Article  CAS  PubMed  Google Scholar 

Zhong L, Chiusa M, Cadar AG, Lin A, Samaras S, Davidson JM, et al. Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy. Cardiovasc Res. 2015;106(2):261–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, et al. MLP and CARP are linked to chronic PKCalpha signalling in dilated cardiomyopathy. Nat Commun. 2016;7:12120.

Article 

Comments (0)

No login
gif