Autophagy: a double-edged sword in ischemia–reperfusion injury

Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, et al. Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem. 2018;46(4):1650–67.

Article  CAS  PubMed  Google Scholar 

Eltzschig HK, Eckle T. Ischemia and reperfusion—from mechanism to translation. Nat Med. 2011;17(11):1391–401.

Article  CAS  PubMed  Google Scholar 

Newton K, Strasser A, Kayagaki N, Dixit VM. Cell death. Cell. 2024;187(2):235–56.

Article  CAS  PubMed  Google Scholar 

Zhou H, He L, Xu G, Chen L. Mitophagy in cardiovascular disease. Clin Chim Acta. 2020;507:210–8.

Article  CAS  PubMed  Google Scholar 

Su L, Zhang J, Gomez H, Kellum JA, Peng Z. Mitochondria ROS and mitophagy in acute kidney injury. Autophagy. 2023;19(2):401–14.

Article  CAS  PubMed  Google Scholar 

Fei Q, Liu J, Qiao L, Zhang M, Xia H, Lu D, et al. Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis. Biochem Biophys Res Commun. 2023;644:140–8.

Article  CAS  PubMed  Google Scholar 

He J, Liu D, Zhao L, Zhou D, Rong J, Zhang L, et al. Myocardial ischemia/reperfusion injury: mechanisms of injury and implications for management (Review). Exp Ther Med. 2022;23(6):430.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2011;12(1):9–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Tsvetkov AS, Shen H-M, Isidoro C, Ktistakis NT, Linkermann A, et al. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy. 2024;20(6):1213–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Yao S, Yang H, Liu S, Wang Y. Autophagy: regulator of cell death. Cell Death Dis. 2023. https://doi.org/10.1038/s41419-023-06154-8.

Article  PubMed  PubMed Central  Google Scholar 

Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728–41.

Article  CAS  PubMed  Google Scholar 

Dugbartey GJ. Cellular and molecular mechanisms of cell damage and cell death in ischemia–reperfusion injury in organ transplantation. Mol Biol Rep. 2024;51(1):473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi ME. Autophagy in kidney disease. Annu Rev Physiol. 2020;82(1):297–322.

Article  CAS  PubMed  Google Scholar 

Tang C, Livingston MJ, Liu Z, Dong Z. Autophagy in kidney homeostasis and disease. Nat Rev Nephrol. 2020;16(9):489–508.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miceli C, Leri M, Stefani M, Bucciantini M. Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases. Ageing Res Rev. 2023;89: 101967.

Article  CAS  PubMed  Google Scholar 

Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. 2019;176(1–2):11–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang S, Sun J, Mohammadtursun N, Hu Z, Li Q, Zhao Z, et al. Dual role of autophagy/mitophagy in chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2019;56:116–25.

Article  CAS  PubMed  Google Scholar 

Tekirdag K, Cuervo AM. Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone. J Biol Chem. 2018;293(15):5414–24.

Article  CAS  PubMed  Google Scholar 

Oku M, Sakai Y. Three distinct types of microautophagy based on membrane dynamics and molecular machineries. BioEssays. 2018;40(6): e1800008.

Article  PubMed  Google Scholar 

Liu Y, Li L, Wang Z, Zhang J, Zhou Z. Myocardial ischemia–reperfusion injury; molecular mechanisms and prevention. Microvas Res. 2023. https://doi.org/10.1016/j.mvr.2023.104565.

Article  Google Scholar 

Cai C, Guo Z, Chang X, Li Z, Wu F, He J, et al. Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway. Redox Biol. 2022. https://doi.org/10.1016/j.redox.2022.102288.

Article  PubMed  PubMed Central  Google Scholar 

Li X, He S, Ma B. Autophagy and autophagy-related proteins in cancer. Mol Cancer. 2020;19(1):12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizzuto R, Bernardi P, Pozzan T. Mitochondria as all-round players of the calcium game. J Physiol. 2000;529(1):37–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lamark T, Svenning S, Johansen T. Regulation of selective autophagy: the p62/SQSTM1 paradigm. Essays Biochem. 2017;61(6):609–24.

Article  PubMed  Google Scholar 

Ren J, Zhang Y. Targeting autophagy in aging and aging-related cardiovascular diseases. Trends Pharmacol Sci. 2018;39(12):1064–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, et al. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. Autophagy. 2021;17(5):1157–69.

Article  CAS  PubMed  Google Scholar 

Wu MY, Lu JH. Autophagy and macrophage functions: inflammatory response and phagocytosis. Cells. 2019;9(1):70.

Article  PubMed  PubMed Central  Google Scholar 

Yang M, Linn BS, Zhang Y, Ren J. Mitophagy and mitochondrial integrity in cardiac ischemia–reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2019;1865(9):2293–302.

Article  CAS  PubMed  Google Scholar 

Sukumaran P, Nascimento Da Conceicao V, Sun Y, Ahamad N, Saraiva LR, Selvaraj S, et al. Calcium signaling regulates autophagy and apoptosis. Cells. 2021;10(8):2125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aghaei M, Motallebnezhad M, Ghorghanlu S, Jabbari A, Enayati A, Rajaei M, et al. Targeting autophagy in cardiac ischemia/reperfusion injury: a novel therapeutic strategy. J Cell Physiol. 2019;234(10):16768–78.

Article  CAS  PubMed  Google Scholar 

Anzell AR, Maizy R, Przyklenk K, Sanderson TH. Mitochondrial quality control and disease: insights into ischemia–reperfusion injury. Mol Neurobiol. 2018;55(3):2547–64.

Article  CAS 

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