Yang W, Tao K, Zhang P, Chen X, Sun X, Li R. Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response. Biochem Pharmacol. 2022;195: 114863.
Article CAS PubMed Google Scholar
Gharavi AT, Hanjani NA, Movahed E, Doroudian M. The role of macrophage subtypes and exosomes in immunomodulation. Cell Mol Biol Lett. 2022;27:83.
Article CAS PubMed PubMed Central Google Scholar
Novakovic B, Habibi E, Wang SY, Arts RJW, Davar R, Megchelenbrink W, et al. β-glucan reverses the epigenetic state of LPS-induced immunological tolerance. Cell. 2016;167:1354-68.e14.
Article CAS PubMed PubMed Central Google Scholar
Ju C, Ma Y, Zuo X, Wang X, Song Z, Zhang Z, et al. Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis. Cell Mol Biol Lett. 2023;28:5.
Article CAS PubMed PubMed Central Google Scholar
Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, et al. MYC sensitises cells to apoptosis by driving energetic demand. Nat Commun. 2022;13:4674.
Article CAS PubMed PubMed Central Google Scholar
Chakraborty S, Balan M, Sabarwal A, Choueiri TK, Pal S. Metabolic reprogramming in renal cancer: events of a metabolic disease. Biochim Biophys Acta. 2021;1876: 188559.
Yang D, Peng M, Hou Y, Qin Y, Wan X, Zhu P, et al. Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation. Cell Death Dis. 2020;11:508.
Article CAS PubMed PubMed Central Google Scholar
Shi J, Cai C. Research progress on the mechanism of itaconate regulating macrophage immunometabolism. Front Immunol. 2022;13: 937247.
Article CAS PubMed PubMed Central Google Scholar
Peace CG, O’Neill LA. The role of itaconate in host defense and inflammation. J Clin Investig. 2022. https://doi.org/10.1172/JCI148548.
Article PubMed PubMed Central Google Scholar
Li R, Zhang P, Wang Y, Tao K. Itaconate: a metabolite regulates inflammation response and oxidative stress. Oxid Med Cell Longev. 2020;2020:5404780.
PubMed PubMed Central Google Scholar
Ye DY, Noh MH, Moon JH, Milito A, Kim M, Lee JW, et al. Kinetic compartmentalization by unnatural reaction for itaconate production. Nat Commun. 2022;13:5353.
Article CAS PubMed PubMed Central Google Scholar
Shin JH, Yang JY, Jeon BY, Yoon YJ, Cho SN, Kang YH, et al. (1)H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis. J Proteome Res. 2011;10:2238–47.
Article CAS PubMed Google Scholar
Strelko CL, Lu W, Dufort FJ, Seyfried TN, Chiles TC, Rabinowitz JD, et al. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc. 2011;133:16386–9.
Article CAS PubMed PubMed Central Google Scholar
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, et al. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci USA. 2013;110:7820–5.
Article CAS PubMed PubMed Central Google Scholar
Zhu L, Chen L. Progress in research on paclitaxel and tumor immunotherapy. Cell Mol Biol Lett. 2019;24:40.
Article CAS PubMed PubMed Central Google Scholar
Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, et al. Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature. 2018;556:501–4.
Article CAS PubMed PubMed Central Google Scholar
Hooftman A, O’Neill LAJ. The immunomodulatory potential of the metabolite itaconate. Trends Immunol. 2019;40:687–98.
Article CAS PubMed Google Scholar
Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K. 4-OI attenuates carbon tetrachloride-induced hepatic injury via regulating oxidative stress and the inflammatory response. Front Pharmacol. 2021;12: 651444.
Article CAS PubMed PubMed Central Google Scholar
Zhao J, Guo S, Schrodi SJ, He D. Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications. Cell Mol Biol Lett. 2022;27:108.
Article CAS PubMed PubMed Central Google Scholar
Lin J, Ren J, Gao DS, Dai Y, Yu L. The emerging application of itaconate: promising molecular targets and therapeutic opportunities. Front Chem. 2021;9: 669308.
Article CAS PubMed PubMed Central Google Scholar
Song X, Long D. Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases. Front Neurosci. 2020;14:267.
Article PubMed PubMed Central Google Scholar
Swain A, Bambouskova M, Kim H, Andhey PS, Duncan D, Auclair K, et al. Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nat Metab. 2020;2:594–602.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Zhou YJ, Tang JS, Lan JQ, Kang YY, Wu L, et al. A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro. J Asian Nat Prod Res. 2022;24:577–88.
Article CAS PubMed Google Scholar
ElAzzouny M, Tom CT, Evans CR, Olson LL, Tanga MJ, Gallagher KA, et al. Dimethyl itaconate is not metabolized into itaconate intracellularly. J Biol Chem. 2017;292:4766–9.
Article CAS PubMed PubMed Central Google Scholar
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556:113–7.
Article CAS PubMed PubMed Central Google Scholar
Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, et al. The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation. Cell Metab. 2020;32:468-78.e7.
Article CAS PubMed PubMed Central Google Scholar
Marrocco A, Frawley K, Pearce LL, Peterson J, O’Brien JP, Mullett SJ, et al. Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol. 2021;207:1627–40.
Article CAS PubMed PubMed Central Google Scholar
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, et al. Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. Nat Metab. 2022;4:524–33.
Article CAS PubMed PubMed Central Google Scholar
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, et al. Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nat Metab. 2022;4:534–46.
Article CAS PubMed PubMed Central Google Scholar
Wolska A, Lech-Marańda E, Robak T. Toll-like receptors and their role in carcinogenesis and anti-tumor treatment. Cell Mol Biol Lett. 2009;14:248–72.
Article CAS PubMed Google Scholar
Degrandi D, Hoffmann R, Beuter-Gunia C, Pfeffer K. The proinflammatory cytokine-induced IRG1 protein associates with mitochondria. J Interferon Cytoki Res. 2009;29:55–67.
Basler T, Jeckstadt S, Valentin-Weigand P, Goethe R. Mycobacterium paratuberculosis, Mycobacterium smegmatis, and lipopolysaccharide induce different transcriptional and post-transcriptional regulation of the IRG1 gene in murine macrophages. J Leukoc Biol. 2006;79:628–38.
Article CAS PubMed Google Scholar
Kim YJ, Kim JH, Lee KJ, Choi MM, Kim YH, Rhie GE, et al. Botulinum neurotoxin type A induces TLR2-mediated inflammatory responses in macrophages. PLoS ONE. 2015;10: e0120840.
Article PubMed PubMed Central Google Scholar
Kawai T, Takeuchi O, Fujita T, Inoue J, Mühlradt PF, Sato S, et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol. 2001;167:5887–94.
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