Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice

Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, et al. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017;72(11):971–80.

Article  CAS  PubMed  Google Scholar 

Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, et al. Randomized clinical trial of a combination of an inhaled corticosteroid and beta agonist in patients at risk of developing the acute respiratory distress syndrome. Crit Care Med. 2017;45(5):798–805.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guervilly C, Bisbal M, Forel JM, Mechati M, Lehingue S, Bourenne J, et al. Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome. Intensive Care Med. 2017;43(3):408–18.

Article  CAS  PubMed  Google Scholar 

Tongyoo S, Permpikul C, Mongkolpun W, Vattanavanit V, Udompanturak S, Kocak M, et al. Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial. Crit Care. 2016;20(1):329.

Article  PubMed  PubMed Central  Google Scholar 

Song Y, Yao C, Yao Y, Han H, Zhao X, Yu K, et al. Xuebijing injection versus placebo for critically ill patients with severe community-acquired pneumonia: a randomized controlled trial. Crit Care Med. 2019;47(9):e735–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu P, Feng Y, Li H, Chen X, Wang G, Xu S, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tu GW, Zhang Y, Ma JF, Hou JY, Hao GW, Su Y, et al. Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation. Cell Mol Biol Lett. 2023;28(1):24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng KT, Xiong S, Ye Z, Hong Z, Di A, Tsang KM, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127(11):4124–35.

Article  PubMed  PubMed Central  Google Scholar 

Eszlinger M, Holzapfel HP, Voigt C, Arkenau C, Paschke R. RGS 2 expression is regulated by TSH and inhibits TSH receptor signaling. Eur J Endocrinol. 2004;151(3):383–90.

Article  CAS  PubMed  Google Scholar 

DeHelian D, Gupta S, Wu J, Thorsheim C, Estevez B, Cooper M, et al. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. Blood. 2020;136(15):1773–82.

Article  PubMed  PubMed Central  Google Scholar 

Patel J, McNeill E, Douglas G, Hale AB, Bono JD, Lee R, et al. RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nat Commun. 2015;6:6614.

Article  CAS  PubMed  Google Scholar 

Wong GS, Redes JL, Balenga N, McCullough M, Fuentes N, Gokhale A, et al. RGS4 promotes allergen- and aspirin-associated airway hyper-responsiveness by inhibiting PGE2 biosynthesis. J Allergy Clin Immunol. 2020;146(5):1152-1164.e13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruiz de Azua I, Scarselli M, Rosemond E, Gautam D, Jou W, Gavrilova O, et al. RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo. Proc Natl Acad Sci U S A. 2010;107(17):7999–8004.

Article  PubMed  PubMed Central  Google Scholar 

Weisshaar N, Wu J, Ming Y, Madi A, Hotz-Wagenblatt A, Ma S, et al. Rgs16 promotes antitumor CD8+ T cell exhaustion. Sci Immunol. 2022;7(71): eabh1873.

Article  CAS  PubMed  Google Scholar 

Huang D, Chen X, Zeng X, Lao L, Li J, Xing Y, et al. Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer. Nat Immunol. 2021;22(7):865–79.

Article  CAS  PubMed  Google Scholar 

Li Y, Liu M, Yang S, Fuller AM, Karin Eisinger-Mathason TS, Yang S. RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling. Oncogene. 2021;40(14):2553–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahlers KE, Chakravarti B, Fisher RA. RGS6 as a novel therapeutic target in CNS diseases and cancer. AAPS J. 2016;18(3):560–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stewart A, Maity B, Anderegg SP, Allamargot C, Yang J, Fisher RA. Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. Proc Natl Acad Sci U S A. 2015;112(7):E786–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, et al. Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB J. 2014;28(4):1735–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bifsha P, Yang J, Fisher RA, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10(12): e1004863.

Article  PubMed  PubMed Central  Google Scholar 

DeBaker MC, Mitten EH, Rose TR, Marron Fernandez de Velasco E, Gao R, Lee AM, et al. RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice. Br J Pharmacol. 2023. https://doi.org/10.1111/bph.16071.

Article  PubMed  Google Scholar 

Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, et al. RGS6, a modulator of parasympathetic activation in heart. Circ Res. 2010;107(11):1345–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berman DM, Wang Y, Liu Z, Dong Q, Burke LA, Liotta LA, et al. A functional polymorphism in RGS6 modulates the risk of bladder cancer. Cancer Res. 2004;64(18):6820–6.

Article  CAS  PubMed  Google Scholar 

Huang J, Stewart A, Maity B, Hagen J, Fagan RL, Yang J, et al. RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis. Oncogene. 2014;33(27):3604–11.

Article  CAS  PubMed  Google Scholar 

Luo Y, Qin SL, Yu MH, Mu YF, Wang ZS, Zhong M. Prognostic value of regulator of G-protein signaling 6 in colorectal cancer. Biomed Pharmacother. 2015;76:147–52.

Article  CAS  PubMed  Google Scholar 

Maity B, Yang J, Huang J, Askeland RW, Bera S, Fisher RA. Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity. J Biol Chem. 2011;286(2):1409–19.

Article  CAS  PubMed  Google Scholar 

Jiang N, Xue R, Bu F, Tong X, Qiang J, Liu R. Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients. Int J Clin Exp Pathol. 2014;7(7):4120–7.

PubMed  PubMed Central  Google Scholar 

Wang Z, Chen J, Wang S, Sun Z, Lei Z, Zhang HT, et al. RGS6 suppresses TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4. Cell Death Dis. 2022;13(7):656.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahata T, Sengar AS, Basak M, Das K, Pramanick A, Verma SK, et al. Hepatic regulator of G protein signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. Redox Biol. 2021;46: 102105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dao W, Xiao Z, Yang W, Luo X, Xia H, Lu Z. RGS6 drives spinal cord injury by inhibiting AMPK pathway in mice. Dis Markers. 2022;2022:4535652.

Article  PubMed  PubMed Central  Google Scholar 

Crestani B, Dehoux M, Seta N, Cuer M, Aubier M. Cell surface carbohydrates of rat alveolar type II cells in primary culture. Am J Respir Cell Mol Biol. 1993;8(2):145–52.

Article  CAS  PubMed  Google Scholar 

Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, et al. Long-term expanding human airway organoids for disease modeling. EMBO J. 2019;38(4): e100300.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinu T, Todd JL, Gelman AE, Guerra S, Palmer SM. Club cell secretory protein in lung disease: emerging concepts and potential therapeutics. Annu Rev Med. 2023;74:427–41.

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