Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification

Strohmaier S, Wallisch C, Kammer M, Geroldinger A, Heinze G, Oberbauer R, Haller MC. Survival benefit of first single-organ deceased donor kidney transplantation compared with long-term dialysis across ages in transplant-eligible patients with kidney failure. JAMA Netw Open. 2022;5(10): e2234971.

Article  PubMed  PubMed Central  Google Scholar 

Hariharan S, Israni AK, Danovitch G. Long-term survival after kidney transplantation. N Engl J Med. 2021;385(8):729–43.

Article  CAS  PubMed  Google Scholar 

Ekberg H, Tedesco-Silva H, Demirbas A, Vitko S, Nashan B, Gurkan A, Margreiter R, Hugo C, Grinyo JM, Frei U, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med. 2007;357(25):2562–75.

Article  CAS  PubMed  Google Scholar 

Kotton CN, Fishman JA. Viral infection in the renal transplant recipient. J Am Soc Nephrol. 2005;16(6):1758–74.

Article  PubMed  Google Scholar 

Ponticelli C, Favi E, Ferraresso M. New-onset diabetes after kidney transplantation. Medicina (Kaunas). 2021;57(3):1928.

Google Scholar 

Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. Immunity. 2006;25(4):559–70.

Article  CAS  PubMed  Google Scholar 

Yigit B, Wang N, Herzog RW, Terhorst C. SLAMF6 in health and disease: implications for therapeutic targeting. Clin Immunol. 2019;204:3–13.

Article  CAS  PubMed  Google Scholar 

De Calisto J, Wang N, Wang G, Yigit B, Engel P, Terhorst C. SAP-dependent and -independent regulation of innate T cell development involving SLAMF receptors. Front Immunol. 2014;5:186.

Article  PubMed  PubMed Central  Google Scholar 

Kageyama R, Cannons JL, Zhao F, Yusuf I, Lao C, Locci M, Schwartzberg PL, Crotty S. The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity. 2012;36(6):986–1002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dooley BJ, Verma A, Ding R, Yang H, Muthukumar T, Lubetzky M, Shankaranarayanan D, Elemento O, Suthanthiran M. Urinary cell transcriptome profiling and identification of ITM2A, SLAMF6, and IKZF3 as biomarkers of acute rejection in human kidney allografts. Transplant Direct. 2020;6(8): e588.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang N, Keszei M, Halibozek P, Yigit B, Engel P, Terhorst C. Slamf6 negatively regulates autoimmunity. Clin Immunol. 2016;173:19–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mendt M, Rezvani K, Shpall E. Mesenchymal stem cell-derived exosomes for clinical use. Bone Marrow Transplant. 2019;54(Suppl 2):789–92.

Article  PubMed  Google Scholar 

Huang W, Qu M, Li L, Liu T, Lin M, Yu X. SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats. Stem Cell Res Ther. 2021;12(1):334.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Xu J, Li M, Zeng X, Wang J, Hu C. Aberrant glycosylation in autoimmune disease. Clin Exp Rheumatol. 2020;38(4):767–75.

PubMed  Google Scholar 

Yao Y, Kim G, Shafer S, Chen Z, Kubo S, Ji Y, Luo J, Yang W, Perner SP, Kanellopoulou C, et al. Mucus sialylation determines intestinal host-commensal homeostasis. Cell. 2022;185(7):1172-1188 e1128.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Batista BS, Eng WS, Pilobello KT, Hendricks-Munoz KD, Mahal LK. Identification of a conserved glycan signature for microvesicles. J Proteome Res. 2011;10(10):4624–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin H, Sun C, Zhu Y, Qin Y, Ren S, Wang Z, Li C, Li X, Zhang B, Hao J, et al. IL-37 overexpression promotes endometrial regenerative cell-mediated inhibition of cardiac allograft rejection. Stem Cell Res Ther. 2022;13(1):302.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lan X, Wang G, Xu X, Lu S, Li X, Zhang B, Shi G, Zhao Y, Du C, Wang H. Stromal cell-derived factor-1 mediates cardiac allograft tolerance induced by human endometrial regenerative cell-based therapy. Stem Cells Transl Med. 2017;6(11):1997–2008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Hosiawa KA, Min W, Yang J, Zhang X, Garcia B, Ichim TE, Zhou D, Lian D, Kelvin DJ, et al. Cytokines regulate the pattern of rejection and susceptibility to cyclosporine therapy in different mouse recipient strains after cardiac allografting. J Immunol. 2003;171(7):3823–36.

Article  CAS  PubMed  Google Scholar 

Stewart S, Winters GL, Fishbein MC, Tazelaar HD, Kobashigawa J, Abrams J, Andersen CB, Angelini A, Berry GJ, Burke MM, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24(11):1710–20.

Article  PubMed  Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7): e47.

Article  PubMed  PubMed Central  Google Scholar 

Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol. 2019;37(7):773–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, Zhong A, Wang S, Dong N, Sun Z, Xia J. Retinoic acid attenuates acute heart rejection by increasing regulatory T cell and repressing differentiation of Th17 cell in the presence of TGF-beta. Transpl Int. 2010;23(10):986–97.

Article  PubMed  Google Scholar 

Wang H, Li C, Xiong Z, Li T. Luteolin attenuates acute liver allograft rejection in rats by inhibiting T cell proliferation and regulating T cell subsets. Int Immunopharmacol. 2023;121: 110407.

Article  CAS  PubMed  Google Scholar 

de Mare-Bredemeijer EL, Mancham S, Verstegen MM, de Ruiter PE, van Gent R, O’Neill D, Tilanus HW, Metselaar HJ, de Jonge J, Kwekkeboom J, et al. Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses. Stem Cells Dev. 2015;24(12):1436–47.

Article  PubMed  Google Scholar 

Li H, Chen Y, Jin Q, Wu Y, Deng C, Gai Y, Sun Z, Li Y, Wang J, Yang Y, et al. Noninvasive radionuclide molecular imaging of the CD4-positive T lymphocytes in acute cardiac rejection. Mol Pharm. 2021;18(3):1317–26.

Article  CAS  PubMed  Google Scholar 

Zheng Q, Zhang S, Guo WZ, Li XK. The unique immunomodulatory properties of MSC-derived exosomes in organ transplantation. Front Immunol. 2021;12: 659621.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Li X, Yu D, Hu Y, Jin W, Qin Y, Kong D, Wang H, Li G, Alessandrini A, et al. Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice. Stem Cell Res Ther. 2020;11(1):471.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Y, Kong D, Qin Y, Yu D, Jin W, Li X, Zhao Y, Wang H, Li G, Hao J, et al. CD73 expression is critical to therapeutic effects of human endometrial regenerative cells in inhibition of cardiac allograft rejection in mice. Stem Cells Transl Med. 2021;10(3):465–78.

Article  CAS  PubMed  Google Scholar 

Chatterjee M, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol. 2012;188(3):1206–12.

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