Prediction of Post-Stroke Cognitive Impairment Based on Iron Metabolism Parameters: Results From A Prospective Study

Mijajlovic MD, Pavlovic A, Brainin M, Heiss WD, Quinn TJ, Ihle-Hansen HB et al (2017) Post-stroke dementia - a comprehensive review. BMC Med 15(1):11. https://doi.org/10.1186/s12916-017-0779-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KY, Shin KY, Chang KA (2022) Potential biomarkers for post-stroke cognitive impairment: a systematic review and meta-analysis. Int J Mol Sci 23(2). https://doi.org/10.3390/ijms23020602

Huang YY, Chen SD, Leng XY, Kuo K, Wang ZT, Cui M et al (2022) Post-stroke cognitive impairment: epidemiology, risk factors, and management. J Alzheimers Dis 86(3):983–999. https://doi.org/10.3233/JAD-215644

Article  PubMed  Google Scholar 

Todorich B, Pasquini JM, Garcia CI, Paez PM, Connor JR (2009) Oligodendrocytes and myelination: the role of iron. Glia 57(5):467–478. https://doi.org/10.1002/glia.20784

Article  PubMed  Google Scholar 

Gleason A, Bush AI (2021) Iron and ferroptosis as therapeutic targets in alzheimer's disease. Neurotherapeutics 18(1):252–264. https://doi.org/10.1007/s13311-020-00954-y

Article  PubMed  Google Scholar 

Rouault TA (2013) Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat Rev Neurosci 14(8):551–564. https://doi.org/10.1038/nrn3453

Article  CAS  PubMed  Google Scholar 

Rivera-Mancia S, Perez-Neri I, Rios C, Tristan-Lopez L, Rivera-Espinosa L, Montes S (2010) The transition metals copper and iron in neurodegenerative diseases. Chem Biol Interact 186(2):184–199. https://doi.org/10.1016/j.cbi.2010.04.010

Article  CAS  PubMed  Google Scholar 

Ayton S, Diouf I, Bush AI (2018) Alzheimer's disease neuroimaging I. Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study. J Neurol Neurosurg Psychiatry 89(5):456–460. https://doi.org/10.1136/jnnp-2017-316551

Article  PubMed  Google Scholar 

Rao SS, Adlard PA (2018) Untangling tau and iron: exploring the interaction between iron and tau in neurodegeneration. Front Mol Neurosci 11:276. https://doi.org/10.3389/fnmol.2018.00276

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Q, Zhou Y, Chen Y, Hu W, Jin W, Zhou C et al (2025) Role of iron in brain development, aging, and neurodegenerative diseases. Ann Med 57(1):2472871. https://doi.org/10.1080/07853890.2025.2472871

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galaris D, Barbouti A, Pantopoulos K (2019) Iron homeostasis and oxidative stress: an intimate relationship. Biochim Biophys Acta Mol Cell Res 1866(12):118535. https://doi.org/10.1016/j.bbamcr.2019.118535

Article  CAS  PubMed  Google Scholar 

Howard CM, Jain S, Cook AD, Packard LE, Mullin HA, Chen NK et al (2022) Cortical iron mediates age-related decline in fluid cognition. Hum Brain Mapp 43(3):1047–1060. https://doi.org/10.1002/hbm.25706

Article  PubMed  Google Scholar 

Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC et al (2020) Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry 25(11):2932–2941. https://doi.org/10.1038/s41380-019-0375-7

Article  CAS  PubMed  Google Scholar 

Schiepers OJ, van Boxtel MP, de Groot RH, Jolles J, de Kort WL, Swinkels DW et al (2010) Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: results from the FACIT study. J Gerontol A Biol Sci Med Sci 65(12):1312–1321. https://doi.org/10.1093/gerona/glq149

Article  CAS  PubMed  Google Scholar 

Tao Y, Wang Y, Rogers JT, Wang F (2014) Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis. J Alzheimers Dis 42(2):679–690. https://doi.org/10.3233/JAD-140396

Article  CAS  PubMed  Google Scholar 

Xu M, Hu Y, Wu J, Wu Z, Yang S, He J et al (2023) Association between the serum iron and acute cognitive impairment after stroke: a cross-sectional study. J Geriatr Psychiatry Neurol 36(2):121–128. https://doi.org/10.1177/08919887221095874

Article  PubMed  Google Scholar 

Shang T, Ma B, Shen Y, Wei C, Wang Z, Zhai W et al (2022) High neutrophil percentage and neutrophil-lymphocyte ratio in acute phase of ischemic stroke predict cognitive impairment: A single-center retrospective study in China. Front Neurol 13:907486. https://doi.org/10.3389/fneur.2022.907486

Article  PubMed  PubMed Central  Google Scholar 

Stroke--1989 (1989) Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke 20(10):1407–1431. https://doi.org/10.1161/01.str.20.10.1407

Article  Google Scholar 

Delavaran H, Jonsson AC, Lovkvist H, Iwarsson S, Elmstahl S, Norrving B et al (2017) Cognitive function in stroke survivors: a 10-year follow-up study. Acta Neurol Scand 136(3):187–194. https://doi.org/10.1111/ane.12709

Article  CAS  PubMed  Google Scholar 

Guo DX, Zhu ZB, Zhong CK, Bu XQ, Chen LH, Xu T et al (2020) Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction. Neural Regen Res 15(5):922–928. https://doi.org/10.4103/1673-5374.268928

Article  CAS  PubMed  Google Scholar 

Pradeep A, Raghavan S, Przybelski SA, Preboske GM, Schwarz CG, Lowe VJ et al (2024) Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population? Alzheimers Res Ther 16(1):157. https://doi.org/10.1186/s13195-024-01525-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zekry D, Duyckaerts C, Belmin J, Geoffre C, Herrmann F, Moulias R et al (2003) The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy. Neurobiol Aging 24(2):213–219. https://doi.org/10.1016/s0197-4580(02)00066-0

Article  PubMed  Google Scholar 

Conde-Blanco E, Pariente JC, Carreno M, Boget T, Pascual-Diaz S, Centeno M et al (2022) Testing an adapted auditory verbal learning test paradigm for fMRI to lateralize verbal memory in patients with epilepsy. AJNR Am J Neuroradiol 43(10):1445–1452. https://doi.org/10.3174/ajnr.A7622

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sutin AR, Stephan Y, Terracciano A (2019) Verbal fluency and risk of dementia. Int J Geriatr Psychiatry 34(6):863–867. https://doi.org/10.1002/gps.5081

Article  PubMed  PubMed Central  Google Scholar 

Li D, Yu YY, Hu N, Zhang M, Sun FL, Liu L et al (2023) Composite indices of the color-picture version of Boston naming test have better discriminatory power: reliability and validity in a Chinese sample with diverse neurodegenerative diseases. J Alzheimers Dis 94(1):393–404. https://doi.org/10.3233/JAD-221227

Article  PubMed  Google Scholar 

Faria LO, Frois T, Fortes LS, Bertola L, Albuquerque MR (2024) Evaluating the stroop test with older adults: construct validity, short term test-retest reliability, and sensitivity to mental fatigue. Percept Mot Skills 131(4):1120–1144. https://doi.org/10.1177/00315125241253425

Article  PubMed  Google Scholar 

Lessov-Schlaggar CN, Del Rosario OL, Morris JC, Ances BM, Schlaggar BL, Constantino JN (2019) Adaptation of the clinical dementia rating scale for adults with down syndrome. J Neurodev Disord 11(1):39. https://doi.org/10.1186/s11689-019-9300-2

Article  PubMed  PubMed Central  Google Scholar 

Li JT, Qu Y, Gao HL, Li JY, Qin QX, Wang DL et al (2022) A nomogram based on iron metabolism can help identify apathy in patients with Parkinson's disease. Front Aging Neurosci 14:1062964. https://doi.org/10.3389/fnagi.2022.1062964

Article  CAS  PubMed  Google Scholar 

Zhao P, Shi L, Zhang G, Wei C, Zhai W, Shen Y et al (2025) Development and internal validation of a nomogram for predicting cognitive impairment after mild ischemic stroke and transient ischemic attack based on cognitive trajectories: a prospective cohort study. Front Aging Neurosci 17:1427737. https://doi.org/10.3389/fnagi.2025.1427737

Article  PubMed  PubMed Central 

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