Multi-omics Analysis of Energy Metabolism Pathways Across Major Psychiatric Disorders

Mergenthaler P, Lindauer U, Dienel GA, Meisel A (2013) Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci 36(10):587–597

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dienel GA (2019) Brain glucose metabolism: integration of energetics with function. Physiol Rev 99(1):949–1045

Article  CAS  PubMed  Google Scholar 

Deitmer JW, Theparambil SM, Ruminot I, Noor SI, Becker HM (2019) Energy dynamics in the brain: contributions of astrocytes to metabolism and pH homeostasis. Front Neurosci 13:1301

Article  PubMed  PubMed Central  Google Scholar 

Kolar D, Kleteckova L, Brozka H, Vales K (2021) Mini-review: brain energy metabolism and its role in animal models of depression, bipolar disorder, schizophrenia and autism. Neurosci Lett 760:136003

Article  CAS  PubMed  Google Scholar 

Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC et al (2019) Mitochondria, metabolism, and redox mechanisms in psychiatric disorders. Antioxid Redox Signal 31(4):275–317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao S, Xu MD, Wang Y, Zhao ST, Wang J, Chen GF et al (2023) Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice. Nat Commun 14(1):729

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li CT, Su TP, Wang SJ, Tu PC, Hsieh JC (2015) Prefrontal glucose metabolism in medication-resistant major depression. Br J Psychiatry 206(4):316–323

Article  PubMed  Google Scholar 

Wang Y, Cai X, Ma Y, Yang Y, Pan CW, Zhu X et al (2024) Metabolomics on depression: a comparison of clinical and animal research. J Affect Disord 349:559–568

Article  CAS  PubMed  Google Scholar 

Zuccoli GS, Saia-Cereda VM, Nascimento JM, Martins-de-Souza D (2017) The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence. Front Neurosci 11:493

Article  PubMed  PubMed Central  Google Scholar 

Wu C, Ren C, Teng Z, Li S, Silva F, Wu H et al (2021) Cerebral glucose metabolism in bipolar disorder: a voxel-based meta-analysis of positron emission tomography studies. Brain Behav 11(5):e02117

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu WJ, Delbello MP, Jarvis KB, Norris MM, Kim MJ, Weber W et al (2013) Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder. Psychiatry Res 213(3):230–234

Article  CAS  PubMed  Google Scholar 

Henkel ND, Wu X, O’Donovan SM, Devine EA, Jiron JM, Rowland LM et al (2022) Schizophrenia: a disorder of broken brain bioenergetics. Mol Psychiatry 27(5):2393–2404

Article  CAS  PubMed  Google Scholar 

Du F, Cooper AJ, Thida T, Sehovic S, Lukas SE, Cohen BM et al (2014) In vivo evidence for cerebral bioenergetic abnormalities in schizophrenia measured using 31P magnetization transfer spectroscopy. JAMA Psychiat 71(1):19–27

Article  CAS  Google Scholar 

Yuksel C, Chen X, Chouinard VA, Nickerson LD, Gardner M, Cohen T, et al. (2021) Abnormal brain bioenergetics in first-episode psychosis. Schizophr Bull Open 2(1):sgaa073.

Katz Shroitman N, Yitzhaky A, Ben Shachar D, Gurwitz D, Hertzberg L (2023) Meta-analysis of brain samples of individuals with schizophrenia detects down-regulation of multiple ATP synthase encoding genes in both females and males. J Psychiatr Res 158:350–359

Article  PubMed  Google Scholar 

van de Burgt N, van Doesum W, Grevink M, van Niele S, de Koning T, Leibold N et al (2023) Psychiatric manifestations of inborn errors of metabolism: a systematic review. Neurosci Biobehav Rev 144:104970

Article  PubMed  Google Scholar 

Mansur RB, Lee Y, McIntyre RS, Brietzke E (2020) What is bipolar disorder? A disease model of dysregulated energy expenditure. Neurosci Biobehav Rev 113:529–545

Article  PubMed  Google Scholar 

Gu X, Ke S, Wang Q, Zhuang T, Xia C, Xu Y et al (2021) Energy metabolism in major depressive disorder: recent advances from omics technologies and imaging. Biomed Pharmacother 141:111869

Article  CAS  PubMed  Google Scholar 

Fizikova I, Dragasek J, Racay P. (2023) Mitochondrial dysfunction, altered mitochondrial oxygen, and energy metabolism associated with the pathogenesis of schizophrenia. Int J Mol Sci 24(9).

Helaly AMN, (2023) Ghorab D. Schizophrenia as metabolic disease. What are the causes? Metab Brain Dis 38(3):795–804.

Tang Y, Gui H, Tarbox-Berry S, Hu S, Ma X, Wang Q (2021) Editorial: genetic mechanisms of biomarkers in schizophrenia, bipolar disorder and depression. Front Psychiatry 12:736055

Article  PubMed  PubMed Central  Google Scholar 

O’Connell KS, Coombes BJ (2021) Genetic contributions to bipolar disorder: current status and future directions. Psychol Med 51(13):2156–2167

Article  PubMed  PubMed Central  Google Scholar 

Bahrami S, Steen NE, Shadrin A, O’Connell K, Frei O, Bettella F et al (2020) Shared genetic loci between body mass index and major psychiatric disorders: a genome-wide association study. JAMA Psychiat 77(5):503–512

Article  Google Scholar 

Zhang M, Chen J, Yin Z, Wang L, Peng L (2021) The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study. Transl Psychiatry 11(1):633

Article  PubMed  PubMed Central  Google Scholar 

Ryu E, Nassan M, Jenkins GD, Armasu SM, Andreazza A, McElroy SL et al (2018) A genome-wide search for bipolar disorder risk loci modified by mitochondrial genome variation. Mol Neuropsychiatry 3(3):125–134

PubMed  Google Scholar 

Goncalves VF, Cappi C, Hagen CM, Sequeira A, Vawter MP, Derkach A et al (2018) A comprehensive analysis of nuclear-encoded mitochondrial genes in schizophrenia. Biol Psychiatry 83(9):780–789

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goncalves VF, Giamberardino SN, Crowley JJ, Vawter MP, Saxena R, Bulik CM et al (2018) Examining the role of common and rare mitochondrial variants in schizophrenia. PLoS ONE 13(1):e0191153

Article  PubMed  PubMed Central  Google Scholar 

Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A et al (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50(5):668–681

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mullins N, Forstner AJ, O’Connell KS, Coombes B, Coleman JRI, Qiao Z et al (2021) Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet 53(6):817–829

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trubetskoy V, Pardinas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB et al (2022) Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 604(7906):502–508

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27–30

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Furumichi M, Sato Y, Matsuura Y, Ishiguro-Watanabe M (2025) KEGG: biological systems database as a model of the real world. Nucleic Acids Res 53(D1):D672–D677

Article  PubMed  Google Scholar 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM et al (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium Nat Genet 25(1):25–29

CAS  PubMed  Google Scholar 

Comments (0)

No login
gif