Exploring the Role of Serum Lysyl Oxidase (LOX) Levels and LOX Gene Polymorphism (G473A) in Diabetic Nephropathy

Rossing P. Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history. Curr Diab Rep. 2006;6:479–83.

Article  PubMed  Google Scholar 

Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Res Int. 2021;2021:1–17.

Article  Google Scholar 

Fu H, Liu SL, Bastacky SI, Wang X, Tian X-J, Zhou D. Diabetic kidney diseases revisited: a new perspective for a new era. Mol Metab. 2019;30:250–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kolset SO, Reinholt FP, Jenssen T. Diabetic nephropathy and extracellular matrix. J Histochem Cytochem. 2012;60(12):976–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stangenberg S, Saad S, Schilter HC, Zaky A, Gill A, Pollock CA, et al. Lysyl oxidase-like- 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy. Sci Rep. 2018;8(1):9423.

Article  PubMed  PubMed Central  ADS  Google Scholar 

Buckingham B, Reiser KM. Relationship between the content of lysyl oxidase-dependent cross-links in skin collagen, nonenzymatic glycosylation, and long-term complications in type I diabetes mellitus. J Clin Invest. 1990;86(4):1046–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes. 2010;59(12):3159–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song B, Kim D, Nguyen NH, Roy S. Inhibition of diabetes-induced lysyl oxidase overexpression prevents retinal vascular lesions associated with diabetic retinopathy. Retin Cell Biol. 2018;59:5965–72.

CAS  Google Scholar 

Pichu S, Sathiyamoorthy J, Vimalraj S, Viswanathan V, Chatterjee S. Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers. Int J Biol Macromol. 2017;103:242–7.

Article  CAS  PubMed  Google Scholar 

Rajapurkar MM, John GT, Kirpalani AL, et al. What do we know about chronic kidney disease in India: first report of the Indian CKD registry. BMC Nephrol. 2012. https://doi.org/10.1186/1471-2369-13-10.

Article  PubMed  PubMed Central  Google Scholar 

Allison S. The CKD–EPI equation—accurately stratifying risk in CKD. Nat Rev Nephrol. 2012;8(7):371–371.

Article  PubMed  Google Scholar 

Kumari S, Patro ARK, Mishra B, Jena SK. Serum lysyl oxidase levels and lysyl oxidase gene polymorphism in ovarian cancer patients of eastern Indian population. Diagnostics. 2021;12(1):53.

Article  PubMed  PubMed Central  Google Scholar 

Mesarwi OA, Shin M-K, Drager LF, Bevans-Fonti S, Jun JC, Putcha N, et al. Lysyl oxidase as a serum biomarker of liver fibrosis in patients with severe obesity and obstructive sleep apnea. Sleep. 2015;38(10):1583–91.

Article  PubMed  PubMed Central  Google Scholar 

Rimar D, Rosner I, Nov Y, Slobodin G, Rozenbaum M, Halasz K, et al. Brief report: lysyl oxidase is a potential biomarker of fibrosis in systemic sclerosis. Arthritis Rheumatol. 2014;66(3):726–30.

Article  PubMed  Google Scholar 

Zhang X-Q, Li X, Zhou W-Q, Liu X, Huang J-L, Zhang Y-Y, et al. Serum lysyl oxidase is a potential diagnostic biomarker for kidney fibrosis. Am J Nephrol. 2020;51(11):907–18.

Article  CAS  PubMed  Google Scholar 

Li W, Liu G, Chou IN, Kagan HM. Hydrogen peroxide-mediated, lysyl oxidase dependent chemotaxis of vascular smooth muscle cells. J Cell Biochem. 2000;78(4):550–7.

Article  CAS  PubMed  Google Scholar 

Jansen MK, Csiszar K. Intracellular localization of the extracellular matrix enzyme lysyl oxidase in polarized epithelial cells. Matrix Biol. 2007;26(2):136–9.

Article  CAS  PubMed  Google Scholar 

Hayashi K, Fong KSK, Mercier F, Boyd CD. Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues. J Mol Histol. 2004;35(8–9):845–55.

Article  CAS  PubMed  Google Scholar 

Kobayashi H, Ishii M, Chanoki M, Yashiro N, Fushida H, Fukai K, et al. Immunohistochemical localization of lysyl oxidase in normal human skin. Br J Dermatol. 1994;131(3):325–30.

Article  CAS  PubMed  Google Scholar 

Wakasaki H, Ooshima A. Immunohistochemical localization of lysyl oxidase with monoclonal antibodies. Lab Invest. 1990;63(3):377–84.

CAS  PubMed  Google Scholar 

Li W, Nellaiappan K, Strassmaier T, Graham L, Thomas KM. Localization and activity of lysyl oxidase within nuclei of fibrogenic cells. Proc Natl Acad Sci U A. 1997;94(24):12817–22.

Article  CAS  ADS  Google Scholar 

Nellaiappan K, Risitano A, Liu G, Nicklas G, Kagan HM. Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cells. J Cell Biochem. 2000;79(4):576–82.

Article  CAS  PubMed  Google Scholar 

Okkelman IA, Sukaeva AZ, Kirukhina EV, Korneenko TV, Pestov NB. Nuclear translocation of lysyl oxidase is promoted by interaction with transcription repressor p66β. Cell Tissue Res. 2014;358(2):481–9.

Article  CAS  PubMed  Google Scholar 

Nguyen N-H, Kim D, Roy S. High glucose increases binding of lysyl oxidase to extracellular matrix proteins: implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2020;61(4):40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Cong JL, Qu LY, Jiang L, Wang Y. Association between lysyl oxidase G473A polymorphism and ovarian cancer in the Han Chinese population. J Int Med Res. 2012;40(3):917–23.

Article  CAS  PubMed  Google Scholar 

Mukherjee S, Katarkar A, Dhariwal R, Mohanty S, Mahato B, Ray JG, et al. Effect of lysyl oxidase g473 a polymorphism on lysyl oxidase and total soluble collagen expression in oral submucous fibrosis. Asian Pac J Cancer Prev. 2021;22(8):2493–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thorawat A, Nandimath K, Hiremath S, Naikmasur VG. Molecular screening of lysyl oxidase G473A polymorphism in oral submucous fibrosis. J Oral Maxillofac Pathol. 2014;18(2):207–10.

Article  PubMed  PubMed Central  Google Scholar 

Adamopoulos C, Piperi C, Gargalionis AN, Dalagiorgou G, Spilioti E, Korkolopoulou P, et al. Advanced glycation end products upregulate lysyl oxidase and endothelin-1 in human aortic endothelial cells via parallel activation of ERK1/2-NF-κB and JNK-AP-1 signaling pathways. Cell Mol Life Sci. 2016;73(8):1685–98.

Article  CAS  PubMed  Google Scholar 

Papachroni KK, Piperi C, Levidou G, Korkolopoulou P, Pawelczyk L, Kandarakis ED, et al. Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue. J Cell Mol Med. 2010;2460–9(14):10.

Google Scholar 

Comments (0)

No login
gif