Collaborative Ocular Melanoma Study Group, Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group Report no. 26, Arch. Ophthalmol., 2005, vol. 123, pp. 1639–1643. https://doi.org/10.1001/archopht.123.12.1639

Article  Google Scholar 

Smit, K.N., Jager, M.J., De Klein, A., and Kiliҫ, E., Uveal melanoma: Towards a molecular understanding, Prog. Retinal Eye Res., 2020, vol. 75, p. 100800. https://doi.org/10.1016/j.preteyeres.2019.100800

Article  Google Scholar 

Souto, E.B., Zielinska, A., Luis, M., Carbone, C., Martins-Gomes, C., Souto, S.B., and Silva, A.M., Uveal melanoma: Physiopathology and new in situ-specific therapies, Cancer Chemother. Pharmacol., 2019, vol. 84, pp. 15–32. https://doi.org/10.1007/s00280-019-03860-z

Article  CAS  PubMed  Google Scholar 

Amaro, A., Gangemi, R., Piaggio, F., Angelini, G., Barisione, G., Ferrini, S., and Pfeffer, U., The biology of uveal melanoma, Cancer Metastasis Rev., 2017, vol. 36, pp. 109–140. https://doi.org/10.1007/s10555-017-9663-3

Article  PubMed  PubMed Central  Google Scholar 

Mouriaux, F., Zaniolo, K., Bergeron, M.-A., Weidmann, C., De La Fouchardière, A., Fournier, F., Droit, A., Morcos, M.W., Landreville, S., and Guérin, S.L., Effects of long-term serial passaging on the characteristics and properties of cell lines derived from uveal melanoma primary tumors, Invest. Ophthalmol. Visual Sci., 2016, vol. 57, p. 5288. https://doi.org/10.1167/iovs.16-19317

Article  CAS  Google Scholar 

Angi, M., Versluis, M., and Kalirai, H., Culturing uveal melanoma cells, Ocul. Oncol. Pathol., 2015, vol. 1, pp. 126–132. https://doi.org/10.1159/000370150

Article  PubMed  PubMed Central  Google Scholar 

Aughton, K., Shahidipour, H., Djirackor, L., Coupland, S.E., and Kalirai, H., Characterization of uveal melanoma cell lines and primary tumor samples in 3D culture, Transl. Vision Sci. Tech., 2020, vol. 9, p. 39. https://doi.org/10.1167/tvst.9.7.39

Article  Google Scholar 

Saakyan, S.V., Tsygankov, A.Yu., Moiseeva, N.I., Karamysheva, A.F., and Garri, D.D., Assessment of the chemosensitivity of uveal melanoma cells ex vivo, Bull. Exp. Biol. Med., 2020, vol. 170, pp. 142–147. https://doi.org/10.1007/s10517-020-05020-3

Article  CAS  PubMed  Google Scholar 

Jager, M.J., Shields, C.L., Cebulla, C.M., Abdel-Rahman, M.H., Grossniklaus, H.E., Stern, M.-H., Carvajal, R.D., Belfort, R.N., Jia, R., Shields, J.A., et al., Uveal melanoma, Nat. Rev. Dis. Primers, 2020, vol. 6, p. 24. https://doi.org/10.1038/s41572-020-0158-0

Article  PubMed  Google Scholar 

Bertrand, J.U., Steingrimsson, E., Jouenne, F., Bressac-de Paillerets, B., and Larue, L., Melanoma risk and melanocyte biology, Acta Derm.-Venereol., 2020, vol. 100, p. adv00139. https://doi.org/10.2340/00015555-3494

Article  CAS  PubMed  Google Scholar 

Trocmé, E., Mougiakakos, D., Johansson, C.C., All-Eriksson, C., Economou, M.A., Larsson, O., Seregard, S., Kiessling, R., and Lin, Y., Nuclear HER3 is associated with favorable overall survival in uveal melanoma, Int. J. Cancer, 2012, vol. 130, pp. 1120–1127. https://doi.org/10.1002/ijc.26118

Article  CAS  PubMed  Google Scholar 

Amaro, A., Mirisola, V., Angelini, G., Musso, A., Tosetti, F., Esposito, A.I., Perri, P., Lanza, F., Nasciuti, F., Mosci, C., et al., Evidence of epidermal growth factor receptor expression in uveal melanoma: Inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity, Eur. J. Cancer, 2013, vol. 49, pp. 3353–3365. https://doi.org/10.1016/j.ejca.2013.06.011

Article  CAS  PubMed  Google Scholar 

Lai, K., Sharma, V., Jager, M.J., Conway, R.M., and Madigan, M.C., Expression and distribution of MUC18 in human uveal melanoma, Virchows Arch., 2007, vol. 451, pp. 967–976. https://doi.org/10.1007/s00428-007-0498-0

Article  CAS  PubMed  Google Scholar 

Wang, Z., Xu, Q., Zhang, N., Du, X., Xu, G., and Yan, X., CD146, from a melanoma cell adhesion molecule to a signaling receptor, Signal Transduction Targeted Ther., 2020, vol. 5, p. 148. https://doi.org/10.1038/s41392-020-00259-8

Article  CAS  Google Scholar 

Grieco, C., Kohl, F.R., and Kohler, B., Ultrafast radical photogeneration pathways in eumelanin, Photochem. Photobiol., 2023, vol. 99, pp. 680–692. https://doi.org/10.1111/php.13731

Article  CAS  PubMed  Google Scholar 

Buszman, E. and Rozanska, R., Interaction of thioridazine with ocular melanin in vitro, Acta Pol. Pharm., 2003, vol. 60, pp. 257–262.

CAS  PubMed  Google Scholar 

Del Marmol, V., Ito, S., Jackson, I., Vachtenheim, J., Berr, P., Ghanem, G., Morandini, R., Wakamatsu, K., and Huez, G., TRP-1 expression correlates with eu-melanogenesis in human pigment cells in culture, FEBS Lett., 1993, vol. 327, pp. 307–310. https://doi.org/10.1016/0014-5793(93)81010-W

Article  CAS  PubMed  Google Scholar 

Antunes, L.C.M., Cartell, A., de Farias, C.B., Bakos, R.M., Roesler, R., and Schwartsmann, G., Tropomyosin-related kinase receptor and neurotrophin expression in cutaneous melanoma is associated with a poor prognosis and decreased survival, Oncology, 2019, vol. 97, pp. 26–37. https://doi.org/10.1159/000499384

Article  CAS  PubMed  Google Scholar 

Zhang, R., Chen, X., Chen, S., Tang, J., Chen, F., Lin, Y., Reinach, P.S., Yan, X., Tu, L., Duan, H., et al., Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry, Cell. Oncol., 2022, vol. 45, pp. 557–572. https://doi.org/10.1007/s13402-022-00682-9

Article  CAS  Google Scholar 

Kuphal, S. and Bosserhoff, A.K., E-cadherin cell–cell communication in melanogenesis and during development of malignant melanoma, Arch. Biochem. Biophys., 2012, vol. 524, pp. 43–47. https://doi.org/10.1016/j.abb.2011.10.020

Article  CAS  PubMed  Google Scholar 

Lade-Keller, J., Riber-Hansen, R., Guldberg, P., Schmidt, H., Hamilton-Dutoit, S.J., and Steiniche, T., E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression, Br. J. Dermatol., 2013, vol. 169, pp. 618–628. https://doi.org/10.1111/bjd.12426

Article  CAS  PubMed  Google Scholar 

Delgado-Bellido, D., Zamudio-Martínez, E., Fernández-Cortés, M., Herrera-Campos, A.B., Olmedo-Pelayo, J., Perez, C.J., Expósito, J., De Álava, E., Amaral, A.T., Valle, F.O., et al., VE-cadherin modulates β-catenin/TCF-4 to enhance vasculogenic mimicry, Cell Death Dis., 2023, vol. 14, p. 135. https://doi.org/10.1038/s41419-023-05666-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Croce, M., Ferrini, S., Pfeffer, U., and Gangemi, R., Targeted therapy of uveal melanoma: Recent failures and new perspectives, Cancers, 2019, vol. 11, p. 846. https://doi.org/10.3390/cancers11060846

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kassumeh, S., Arrow, S., Kafka, A., Luft, N., Priglinger, S.G., Wolf, A., Eibl-Lindner, K., and Wertheimer, C.M., Pharmacological drug screening to inhibit uveal melanoma metastatic cells either via EGF-R, MAPK, mTOR or PI3K, Int. J. Ophthalmol., 2022, vol. 15, p. 1569.

Article  PubMed  PubMed Central  Google Scholar 

Sigismund, S., Avanzato, D., and Lanzetti, L., Emerging functions of the EGFR in cancer, Mol. Oncol., 2018, vol. 12, pp. 3–20. https://doi.org/10.1002/1878-0261.12155

Article  PubMed  Google Scholar 

Forsberg, E.M.V., Lindberg, M.F., Jespersen, H., Alsén, S., Bagge, R.O., Donia, M., Svane, I.M., Nilsson, O., Ny, L., Nilsson, L.M., et al., HER2 CAR-T cells eradicate uveal melanoma and T-cell therapy–resistant human melanoma in IL2 transgenic NOD/SCID IL2 receptor knockout mice, Cancer Res., 2019, vol. 79, pp. 899–904. https://doi.org/10.1158/0008-5472.CAN-18-3158

Article  CAS  PubMed  Google Scholar 

Burgess, B.L., Rao, N.P., Eskin, A., Nelson, S.F., and McCannel, T.A., Characterization of three cell lines derived from fine needle biopsy of choroidal melanoma with metastatic outcome, Mol. Vision, 2011, vol. 17, pp. 607–615.

CAS  Google Scholar 

Pardo, M., Piñeiro, A., De La Fuente, M., García, A., Prabhakar, S., Zitzmann, N., Dwek, R.A., Sánchez-Salorio, M., Domínguez, F., and Capeans, C., Abnormal cell cycle regulation in primary human uveal melanoma cultures, J. Cell. Biochem., 2004, vol. 93, pp. 708–720. https://doi.org/10.1002/jcb.20230