Korver AM, Smith RJ, Van Camp G, Schleiss MR, Bitner-Glindzicz MA, Lustig LR, et al. Congenital hearing loss. Nat Rev Dis Primers. 2017;3:16094.

Article  PubMed  PubMed Central  Google Scholar 

Angeli S, Lin X, Liu XZ. Genetics of hearing and deafness. Anat Rec. 2012;295(11):1812–29.

Article  CAS  Google Scholar 

Lee KY. Pathophysiology of age-related hearing loss (peripheral and central). Korean J Audiol. 2013;17(2):45–9.

Article  PubMed  PubMed Central  Google Scholar 

Liu W, Johansson A, Rask-Andersen H, Rask-Andersen M. A combined genome-wide association and molecular study of age-related hearing loss in H sapiens. BMC Med. 2021;19(1):302.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Provenzano MJ, Domann FE. A role for epigenetics in hearing: establishment and maintenance of auditory specific gene expression patterns. Hear Res. 2007;233(1–2):1–13.

Article  PubMed  PubMed Central  Google Scholar 

Patil V, Ward RL, Hesson LB. The evidence for functional non-CpG methylation in mammalian cells. Epigenetics. 2014;9(6):823–8.

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting: meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–12.

Article  CAS  PubMed  Google Scholar 

Higgins J MR, Rooney A, Taylor K, Thayer K, Silva R, Lemeris C, Akl A, Arroyave W, Bateson T, Berkman N, Demers P, Forastiere F, Glenn B, Hróbjartsson A, Kirrane E, LaKind J, Luben T, Lunn R, McAleenan A, McGuinness L, Meerpohl J, Mehta S, Nachman R, Obbagy J, O'Connor A, Radke E, Savović J, Schubauer-Berigan M, Schwingl P, Schunemann H, Shea B, Steenland K, Stewart T, Straif K, Tilling K, Verbeek V, Vermeulen R, Viswanathan M, Zahm S, Sterne J. Robins E-Tool Launch version, 20 June 2023 [Available from: https://www.riskofbias.info/welcome/robins-e-tool.

Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.

Article  PubMed  PubMed Central  Google Scholar 

Hao J, Hua L, Fu X, Zhang X, Zou Q, Li Y. Genome-wide DNA methylation analysis of human peripheral blood reveals susceptibility loci of diabetes-related hearing loss. J Hum Genet. 2018;63(12):1241–50.

Article  CAS  PubMed  Google Scholar 

Kuo PL, Moore AZ, Lin FR, Ferrucci L. Epigenetic age acceleration and hearing: observations from the baltimore longitudinal study of aging. Front Aging Neurosci. 2021;13:790926.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Zheng J, Shen W, Ma L, Zhao M, Wang X, et al. Elevated SLC26A4 gene promoter methylation is associated with the risk of presbycusis in men. Mol Med Rep. 2017;16(1):347–52.

Article  CAS  PubMed  Google Scholar 

Xu L, Huo X, Liu Y, Zhang Y, Qin Q, Xu X. Hearing loss risk and DNA methylation signatures in preschool children following lead and cadmium exposure from an electronic waste recycling area. Chemosphere. 2020;246:125829.

Article  CAS  PubMed  Google Scholar 

Bouzid A, Chelly A, Tekari A, Singh N, Hansdah K, Achour I, et al. Genetic Association of rs1021188 and DNA Methylation Signatures of TNFSF11 in the Risk of Conductive Hearing Loss. Front Med. 2022;9.

Bouzid A, Smeti I, Chakroun A, Loukil S, Gibriel AA, Grati M, et al. CDH23 methylation status and presbycusis risk in elderly women. Front Aging Neurosci. 2018;10:241.

Article  PubMed  PubMed Central  Google Scholar 

Flook M, Escalera-Balsera A, Gallego-Martinez A, Espinosa-Sanchez JM, Aran I, Soto-Varela A, et al. Dna methylation signature in mononuclear cells and proinflammatory cytokines may define molecular subtypes in sporadic meniere disease. Biomedicines. 2021;9(11):1530.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo L, Wang W, Song W, Cao H, Tian H, Wang Z, et al. Genome-wide DNA methylation analysis of middle-aged and elderly monozygotic twins with age-related hearing loss in Qingdao. China Gene. 2023;849:146918.

Article  CAS  PubMed  Google Scholar 

Lassaletta L, Bello MJ, Del Río L, Alfonso C, Roda JM, Rey JA, et al. DNA methylation of multiple genes in vestibular schwannoma: relationship with clinical and radiological findings. Otol Neurotol. 2006;27(8):1180–5.

Article  PubMed  Google Scholar 

Bouzid A, Smeti I, Dhouib L, Roche M, Achour I, Khalfallah A, et al. Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis. Biomark Biochem Indicat Expos Resp Suscept Chem. 2018;23(4):347–56.

CAS  Google Scholar 

Brown AL, Foster KL, Lupo PJ, Peckham-Gregory EC, Murray JC, Okcu MF, et al. DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors. Neuro Oncol. 2017;19(10):1372–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolber LE, Steves CJ, Tsai PC, Deloukas P, Spector TD, Bell JT, et al. Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. PLoS ONE. 2014;9(9):e105729.

Article  PubMed  PubMed Central  Google Scholar 

Kernohan KD, Cigana Schenkel L, Huang L, Smith A, Pare G, Ainsworth P, et al. Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy. Clin Epigen. 2016. https://doi.org/10.1186/s13148-016-0254-x.

Article  Google Scholar 

Salameh Y, Bejaoui Y, El Hajj N. DNA Methylation biomarkers in aging and age-related diseases. Front Genet. 2020;11:171.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, et al. Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions. Biol Sex Differ. 2015;6:11.

Article  PubMed  PubMed Central  Google Scholar 

Yousefi P, Huen K, Dave V, Barcellos L, Eskenazi B, Holland N. Sex differences in DNA methylation assessed by 450 K BeadChip in newborns. BMC Genom. 2015;16:911.

Article  Google Scholar 

Yusipov I, Bacalini MG, Kalyakulina A, Krivonosov M, Pirazzini C, Gensous N, et al. Age-related DNA methylation changes are sex-specific: a comprehensive assessment. Aging. 2020;12(23):24057–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singmann P, Shem-Tov D, Wahl S, Grallert H, Fiorito G, Shin SY, et al. Characterization of whole-genome autosomal differences of DNA methylation between men and women. Epigenetics Chromatin. 2015;8:43.

Article  PubMed  PubMed Central  Google Scholar 

Otávio-Augusto- Dos Santos OA, Carneiro RL, Requião RD, Ribeiro-Alves M, Domitrovic T, Palhano FL. Transcriptional profile of ribosome-associated quality control components and their associated phenotypes in mammalian cells. Sci Rep. 2024;14:1439.

Article  PubMed Central  Google Scholar 

Burns JC, Kelly MC, Hoa M, Morell RJ, Kelley MW. Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear. Nat Commun. 2015;6:8557.

Article  CAS  PubMed  Google Scholar 

Hertzano R, Elkon R. High throughput gene expression analysis of the inner ear. Hear Res. 2012;288(1–2):77–88.

Article  CAS  PubMed  Google Scholar 

de Mendoza A, Poppe D, Buckberry S, Pflueger J, Albertin CB, Daish T, et al. The emergence of the brain non-CpG methylation system in vertebrates. Nat Ecol Evol. 2021;5(3):369–78.

Article  PubMed