Islami, F., Ward, E. M., Sung, H., Cronin, K. A., Tangka, F. K. L., Sherman, R. L., et al. (2021). Annual report to the nation on the status of cancer, part 1: National cancer statistics. Journal of the National Cancer Institute, 113(12), 1648–1669. https://doi.org/10.1093/jnci/djab131
Article PubMed PubMed Central Google Scholar
Cronin, K. A., Scott, S., Firth, A. U., Sung, H., Henley, S. J., Sherman, R. L., et al. (2022). Annual report to the nation on the status of cancer, part 1: National cancer statistics. Cancer, 128(24), 4251–4284. https://doi.org/10.1002/cncr.34479
Villanueva, A. (2019). Hepatocellular carcinoma. New England Journal of Medicine, 380(15), 1450–1462. https://doi.org/10.1056/NEJMra1713263
Article CAS PubMed Google Scholar
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
Article CAS PubMed Google Scholar
Ben-Moshe, S., & Itzkovitz, S. (2019). Spatial heterogeneity in the mammalian liver. Nature Reviews. Gastroenterology & Hepatology, 16(7), 395–410. https://doi.org/10.1038/s41575-019-0134-x
Morio, B., Panthu, B., Bassot, A., & Rieusset, J. (2021). Role of mitochondria in liver metabolic health and diseases. Cell Calcium, 94, 102336. https://doi.org/10.1016/j.ceca.2020.102336
Article CAS PubMed Google Scholar
Lu, C., Fang, S., Weng, Q., Lv, X., Meng, M., Zhu, J., et al. (2020). Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma. Cell Communication and Signaling, 18(1), 97. https://doi.org/10.1186/s12964-020-00539-4
Article CAS PubMed PubMed Central Google Scholar
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009). Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science, 324(5930), 1029–1033. https://doi.org/10.1126/science.1160809
Article CAS PubMed PubMed Central Google Scholar
Wang, S., Long, H., Hou, L., Feng, B., Ma, Z., Wu, Y., et al. (2023). The mitophagy pathway and its implications in human diseases. Signal Transduction and Targeted Therapy, 8(1), 304. https://doi.org/10.1038/s41392-023-01503-7
Article PubMed PubMed Central Google Scholar
Zhang, Z., Zhao, Q., Wang, Z., Xu, F., Liu, Y., Guo, Y., et al. (2024). Hepatocellular carcinoma cells downregulate NADH: Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis. Hepatology Communications, 8(3), e0395. https://doi.org/10.1097/HC9.0000000000000395
Article PubMed PubMed Central Google Scholar
Sin, S. Q., Mohan, C. D., Goh, R. M. W., You, M., Nayak, S. C., Chen, L., et al. (2023). Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities. Cancer Metastasis Reviews, 42(3), 741–764. https://doi.org/10.1007/s10555-022-10071-1
Article CAS PubMed Google Scholar
Zhang, Z., Li, T. E., Chen, M., Xu, D., Zhu, Y., Hu, B. Y., et al. (2020). MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming. British Journal of Cancer, 122(2), 209–220. https://doi.org/10.1038/s41416-019-0658-4
Article CAS PubMed Google Scholar
Grasso, D., Zampieri, L. X., Capeloa, T., Van de Velde, J. A., & Sonveaux, P. (2020). Mitochondria in cancer. Cell Stress, 4(6), 114–146. https://doi.org/10.15698/cst2020.06.221
Article CAS PubMed PubMed Central Google Scholar
Marchi, S., Guilbaud, E., Tait, S. W. G., Yamazaki, T., & Galluzzi, L. (2023). Mitochondrial control of inflammation. Nature Reviews. Immunology, 23(3), 159–173. https://doi.org/10.1038/s41577-022-00760-x
Article CAS PubMed Google Scholar
Sullivan, L. B., Gui, D. Y., & Vander Heiden, M. G. (2016). Altered metabolite levels in cancer: Implications for tumour biology and cancer therapy. Nature Reviews. Cancer, 16(11), 680–693. https://doi.org/10.1038/nrc.2016.85
Article CAS PubMed Google Scholar
Glover, H. L., Schreiner, A., Dewson, G., & Tait, S. W. G. (2024). Mitochondria and cell death. Nature Cell Biology, 26(9), 1434–1446. https://doi.org/10.1038/s41556-024-01429-4
Article CAS PubMed Google Scholar
Hu, S., Feng, J., Wang, M., Wufuer, R., Liu, K., Zhang, Z., et al. (2022). Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks. Redox Biology, 57, 102470. https://doi.org/10.1016/j.redox.2022.102470
Article CAS PubMed PubMed Central Google Scholar
Kang, S. W. S., Cunningham, R. P., Miller, C. B., Brown, L. A., Cultraro, C. M., Harned, A., et al. (2024). A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling. Nature Communications, 15(1), 1799. https://doi.org/10.1038/s41467-024-45751-9
Article CAS PubMed PubMed Central Google Scholar
Perugorria, M. J., Olaizola, P., Labiano, I., Esparza-Baquer, A., Marzioni, M., Marin, J. J. G., et al. (2019). Wnt-beta-catenin signalling in liver development, health and disease. Nature Reviews. Gastroenterology & Hepatology, 16(2), 121–136. https://doi.org/10.1038/s41575-018-0075-9
Yu, S., Gao, J., Wang, H., Liu, L., Liu, X., Xu, Y., et al. (2022). Significance of Liver Zonation in Hepatocellular Carcinoma. Frontiers in Cell and Developmental Biology, 10, 806408. https://doi.org/10.3389/fcell.2022.806408
Article PubMed PubMed Central Google Scholar
Ruppert, P. M. M., & Kersten, S. (2024). Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting. Trends in Endocrinology and Metabolism, 35(2), 107–124. https://doi.org/10.1016/j.tem.2023.10.002
Article CAS PubMed Google Scholar
Huang, D., Li, T., Wang, L., Zhang, L., Yan, R., Li, K., et al. (2016). Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Research, 26(10), 1112–1130. https://doi.org/10.1038/cr.2016.109
Article CAS PubMed PubMed Central Google Scholar
Chen, T. H., Wang, H. C., Chang, C. J., & Lee, S. Y. (2024). Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation. International Journal of Molecular Sciences, 25(2), 1314. https://doi.org/10.3390/ijms25021314
Article CAS PubMed PubMed Central Google Scholar
Yakes, F. M., & Van Houten, B. (1997). Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America, 94(2), 514–519. https://doi.org/10.1073/pnas.94.2.514
Article CAS PubMed PubMed Central Google Scholar
Hsiao, Y. F., Cheng, S. B., Lai, C. Y., Liu, H. T., Huang, S. C., & Huang, Y. C. (2021). The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma. Nutrients, 13(11), 4071. https://doi.org/10.3390/nu13114071
Article CAS PubMed PubMed Central Google Scholar
Cheng, S. B., Liu, H. T., Chen, S. Y., Lin, P. T., Lai, C. Y., & Huang, Y. C. (2017). Changes of Oxidative Stress, Glutathione, and Its Dependent Antioxidant Enzyme Activities in Patients with Hepatocellular Carcinoma before and after Tumor Resection. PLoS ONE, 12(1), e0170016. https://doi.org/10.1371/journal.pone.0170016
Article CAS PubMed PubMed Central Google Scholar
Sun, L., Wang, Y., Cen, J., Ma, X., Cui, L., Qiu, Z., et al. (2019). Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes. Nature Cell Biology, 21(8), 1015–1026.
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