Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ et al (2013) Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev 93(3):1247–1288. https://doi.org/10.1152/physrev.00037.2012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calovi S, Mut-Arbona P, Sperlagh B (2019) Microglia and the purinergic signaling system. Neuroscience 405:137–147. https://doi.org/10.1016/j.neuroscience.2018.12.021

Article  CAS  PubMed  Google Scholar 

Farber K, Kettenmann H (2006) Purinergic signaling and microglia. Pflugers Arch 452(5):615–621 (Epub 2006 Jun 21)

Article  PubMed  Google Scholar 

Schedlowski M, Engler H, Grigoleit JS (2014) Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun 35:1–8. https://doi.org/10.1016/j.bbi.2013.09.015

Article  CAS  PubMed  Google Scholar 

Wolf SA, Boddeke HW, Kettenmann H (2017) Microglia in physiology and disease. Annu Rev Physiol 79:619–643. https://doi.org/10.1146/annurev-physiol-022516-034406

Article  CAS  PubMed  Google Scholar 

Paolicelli RC, Sierra A, Stevens B et al (2022) Microglia states and nomenclature: a field at its crossroads. Neuron 110(21):3458–3483. https://doi.org/10.1016/j.neuron.2022.10.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirbec H, Marmai C, Duroux-Richard I et al (2018) The microglial reaction signature revealed by RNAseq from individual mice. Glia 66(5):971–986. https://doi.org/10.1002/glia.23295

Article  PubMed  Google Scholar 

Ulmann L, Hatcher JP, Hughes JP et al (2008) Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 28(44):11263–11268

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuda M, Shigemoto-Mogami Y, Koizumi S et al (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424(6950):778–783. https://doi.org/10.1038/nature01786

Article  CAS  PubMed  Google Scholar 

Haynes SE, Hollopeter G, Yang G et al (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12):1512–1519

Article  CAS  PubMed  Google Scholar 

Antonioli L, Blandizzi C, Fornai M et al (2019) P2X4 receptors, immunity, and sepsis. Curr Opin Pharmacol 47:65–74. https://doi.org/10.1016/j.coph.2019.02.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coull JA, Beggs S, Boudreau D et al (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438(7070):1017–1021. https://doi.org/10.1038/nature04223

Article  CAS  PubMed  Google Scholar 

Ulmann L, Levavasseur F, Avignone E et al (2013) Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus. Glia 61(8):1306–1319. https://doi.org/10.1002/glia.22516

Article  PubMed  Google Scholar 

Hua J, Garcia de Paco E, Linck N et al (2023) Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer’s disease. Cell Mol Life Sci 80(5):138. https://doi.org/10.1007/s00018-023-04784-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung S, Aliberti J, Graemmel P et al (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106–4114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ulmann L, Hirbec H, Rassendren F (2010) P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. Embo J 29(14):2290–2300

Article  CAS  PubMed  PubMed Central  Google Scholar 

Philippe N, Salson M, Commes T et al (2013) CRAC: an integrated approach to the analysis of RNA-seq reads. Genome Biol 14(3):R30. https://doi.org/10.1186/gb-2013-14-3-r30

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30(7):923–930. https://doi.org/10.1093/bioinformatics/btt656

Article  CAS  PubMed  Google Scholar 

Robinson MD, McCarthy DJ, Smyth GK (2010) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26(1):139–140. https://doi.org/10.1093/bioinformatics/btp616

Article  CAS  PubMed  Google Scholar 

Le S, Josse J, Husson F (2008) FactoMineR: an R package for multivariate analysis. J Stat Softw 25(1):1–18. https://doi.org/10.18637/jss.v025.i01

Article  Google Scholar 

Ogata H, Goto S, Sato K et al (1999) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 27(1):29–34. https://doi.org/10.1093/nar/27.1.29

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jassal B, Matthews L, Viteri G et al (2020) The reactome pathway knowledgebase. Nucleic Acids Res 48(D1):D498–D503. https://doi.org/10.1093/nar/gkz1031

Article  CAS  PubMed  Google Scholar 

Subramanian A, Tamayo P, Mootha VK et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):15545–15550. https://doi.org/10.1073/pnas.0506580102

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bechade C, D’Andrea I, Etienne F et al (2021) The serotonin 2B receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood. Glia 69(3):638–654. https://doi.org/10.1002/glia.23918

Article  CAS  PubMed  Google Scholar 

Zhang Y, Chen K, Sloan SA et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34(36):11929–11947. https://doi.org/10.1523/JNEUROSCI.1860-14.2014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levine DM, Haynor DR, Castle JC et al (2006) Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways. Genome Biol 7(10):R93. https://doi.org/10.1186/gb-2006-7-10-r93

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silvin A, Uderhardt S, Piot C et al (2022) Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 55(8):1448-1465 e6. https://doi.org/10.1016/j.immuni.2022.07.00

Article  CAS  PubMed  Google Scholar 

Sousa C, Golebiewska A, Poovathingal SK, et al. (2018) Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Rep 19(11) https://doi.org/10.15252/embr.201846171

Cecconi M, Evans L, Levy M et al (2018) Sepsis and septic shock. Lancet 392(10141):75–87. https://doi.org/10.1016/S0140-6736(18)30696-2

Article