Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration

Knezevic NN, Candido KD, Vlaeyen JWS, Van Zundert J, Cohen SP. Low back pain. Lancet. 2021;398:78–92.

Article  PubMed  Google Scholar 

Hartvigsen J, Hancock MJ, Kongsted A, Louw Q, Ferreira ML, Genevay S, et al. What low back pain is and why we need to pay attention. Lancet. 2018;391:2356–67.

Article  PubMed  Google Scholar 

Urits I, Burshtein A, Sharma M, Testa L, Gold PA, Orhurhu V, et al. Low back pain, a comprehensive review: pathophysiology, diagnosis, and treatment. Curr Pain Headache Rep. 2019;23:23.

Article  PubMed  Google Scholar 

Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10:44–56.

Article  CAS  PubMed  Google Scholar 

Xin J, Wang Y, Zheng Z, Wang S, Na S, Zhang S. Treatment of intervertebral disc degeneration. Orthop Surg. 2022;14:1271–80.

Article  PubMed  PubMed Central  Google Scholar 

Wu PH, Kim HS, Jang IT. Intervertebral disc diseases PART 2: a review of the current diagnostic and treatment strategies for intervertebral disc disease. Int J Mol Sci. 2020;21(6):2135.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohnishi T, Iwasaki N, Sudo H. Causes of and molecular targets for the treatment of intervertebral disc degeneration: a review. Cells. 2022;11(3):394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lundon K, Bolton K. Structure and function of the lumbar intervertebral disk in health, aging, and pathologic conditions. J Orthop Sports Phys Ther. 2001;31:291–303.

Article  CAS  PubMed  Google Scholar 

Guerrero J, Häckel S, Croft AS, Hoppe S, Albers CE, Gantenbein B. The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth? Eur Cell Mater. 2021;41:707–38.

Article  CAS  PubMed  Google Scholar 

Song C, Cai W, Liu F, Cheng K, Guo D, Liu Z. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR Spine. 2022;5: e1233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song C, Zhou Y, Cheng K, Liu F, Cai W, Zhou D, et al. Cellular senescence—molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomed Pharmacother. 2023;162: 114711.

Article  CAS  PubMed  Google Scholar 

Song C, Chen R, Cheng K, Zhou D, Mei Y, Yan J, et al. Exploring the pharmacological mechanism of Duhuo Jisheng Decoction in treating intervertebral disc degeneration based on network pharmacology. Medicine (Baltimore). 2023;102: e33917.

Article  CAS  PubMed  Google Scholar 

Zhou D, Song C, Mei Y, Cheng K, Liu F, Cai W, et al. A review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies. J Orthop Surg Res. 2023;18:436.

Article  PubMed  PubMed Central  Google Scholar 

Liu ZC, Wang ZL, Huang CY, Fu ZJ, Liu Y, Wei ZC, et al. Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway. Acta Pharmacol Sin. 2018;39:912–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Z, Wang H, Song J, Xu G, Lu F, Ma X, et al. The role of mitochondrial fission in intervertebral disc degeneration. Osteoarthr Cartil. 2023;31:158–66.

Article  CAS  Google Scholar 

Zeng Z, Zhou X, Wang Y, Cao H, Guo J, Wang P, et al. Mitophagy-a new target of bone disease. Biomolecules. 2022;12(10):1420.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang GZ, Deng YJ, Xie QQ, Ren EH, Ma ZJ, He XG, et al. Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function. Clin Chim Acta. 2020;508:33–42.

Article  CAS  PubMed  Google Scholar 

Zhang C, Peng X, Wang F, Xie Z, Chen L, Wu X. Update on the correlation between mitochondrial dysfunction and intervertebral disk degeneration. DNA Cell Biol. 2022;41:257–61.

Article  CAS  PubMed  Google Scholar 

Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012;148:1145–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos JH. Mitochondria signaling to the epigenome: a novel role for an old organelle. Free Radic Biol Med. 2021;170:59–69.

Article  CAS  PubMed  Google Scholar 

van der Bliek AM, Sedensky MM, Morgan PG. Cell Biology of the mitochondrion. Genetics. 2017;207:843–71.

Article  PubMed  PubMed Central  Google Scholar 

Csordás G, Weaver D, Hajnóczky G. Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions. Trends Cell Biol. 2018;28:523–40.

Article  PubMed  PubMed Central  Google Scholar 

Greber BJ, Ban N. Structure and function of the mitochondrial ribosome. Annu Rev Biochem. 2016;85:103–32.

Article  CAS  PubMed  Google Scholar 

Szymański J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Ziółkowski W, et al. Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci. 2017;18(7):1576.

Article  PubMed  PubMed Central  Google Scholar 

Francisco V, Pino J, González-Gay M, Lago F, Karppinen J, Tervonen O, et al. A new immunometabolic perspective of intervertebral disc degeneration. Nat Rev Rheumatol. 2022;18:47–60.

Article  CAS  PubMed  Google Scholar 

Cheng Z, Xiang Q, Wang J, Zhang Y. The potential role of melatonin in retarding intervertebral disc ageing and degeneration: a systematic review. Ageing Res Rev. 2021;70: 101394.

Article  CAS  PubMed  Google Scholar 

Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, et al. Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1α-BNIP3 Axis. J Bone Miner Res. 2020;35:1504–24.

Article  CAS  PubMed  Google Scholar 

Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, et al. HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3. Exp Mol Med. 2022;54:309–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song Y, Li S, Geng W, Luo R, Liu W, Tu J, et al. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox Biol. 2018;19:339–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Toan S, Zhou H. New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury. Angiogenesis. 2020;23:299–314.

Article  PubMed  Google Scholar 

Forte M, Schirone L, Ameri P, Basso C, Catalucci D, Modica J, et al. The role of mitochondrial dynamics in cardiovascular diseases. Br J Pharmacol. 2021;178:2060–76.

Article  CAS  PubMed  Google Scholar 

Hu C, Huang Y, Li L. Drp1-dependent mitochondrial fission plays critical roles in physiological and pathological progresses in mammals. Int J Mol Sci. 2017;18(1):144.

Article  PubMed  PubMed Central  Google Scholar 

Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, et al. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res. 2013;31:1150–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallace DC. Mitochondria and cancer. Nat Rev Cancer. 2012;12:685–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng C, Yang M, Lan M, Liu C, Zhang Y, Huang B, et al. ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. Oxid Med Cell Longev. 2017;2017:5601593.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Cheng H, Wang T, Zhang K, Zhang Y, Kang X. Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment. Cell Prolif. 2023. https://doi.org/10.1111/cpr.13448.

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif