Henderson I, Caiazzo E, McSharry C, Guzik TJ, Maffia P. Why do some asthma patients respond poorly to glucocorticoid therapy? Pharmacol Res. 2020;160:105189.
Article CAS PubMed PubMed Central Google Scholar
Marshall CL, Hasani K, Mookherjee N. Immunobiology of steroid-unresponsive severe asthma. Front Allergy. 2021;2:718267.
Article PubMed PubMed Central Google Scholar
Rider CF, Carlsten C. Air pollution and resistance to inhaled glucocorticoids: evidence, mechanisms and gaps to fill. Pharmacol Ther. 2019;194:1–21.
Article CAS PubMed Google Scholar
Brandt EB, Bolcas PE, Ruff BP, Khurana Hershey GK. IL33 contributes to diesel pollution-mediated increase in experimental asthma severity. Allergy. 2020;75:2254–66.
Article CAS PubMed Google Scholar
Park CO, Kupper TS. The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat Med. 2015;21:688–97.
Article CAS PubMed PubMed Central Google Scholar
Bosnjak B, Kazemi S, Altenburger LM, Mokrovic G, Epstein MM. Th2-T(RMs) maintain life-long allergic memory in experimental asthma in mice. Front Immunol. 2019;10:840.
Article CAS PubMed PubMed Central Google Scholar
Wiest M, Upchurch K, Yin W, Ellis J, Xue Y, Lanier B, et al. Clinical implications of CD4(+) T cell subsets in adult atopic asthma patients. Allergy Asthma Clin Immunol. 2018;14:7.
Article PubMed PubMed Central Google Scholar
Palikhe NS, Laratta C, Nahirney D, Vethanayagam D, Bhutani M, Vliagoftis H, et al. Elevated levels of circulating CD4(+) CRTh2(+) T cells characterize severe asthma. Clin Exp Allergy. 2016;46:825–36.
Article CAS PubMed Google Scholar
Brandt EB, Biagini Myers JM, Acciani TH, Ryan PH, Sivaprasad U, Ruff B, et al. Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J Allergy Clin Immunol. 2015;136:295–303. e7.
Article CAS PubMed PubMed Central Google Scholar
Perl A. mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging. Ann N Y Acad Sci. 2015;1346:33–44.
Article CAS PubMed PubMed Central Google Scholar
Chi H. Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol. 2012;12:325–38.
Article CAS PubMed PubMed Central Google Scholar
Yin Y, Mitson-Salazar A, Wansley DL, Singh SP, Prussin C. Rapamycin preferentially inhibits human IL-5(+) T(H)2-cell proliferation via an mTORC1/S6 kinase-1-dependent pathway. J Allergy Clin Immunol. 2017;139:1701–e170410.
Article CAS PubMed Google Scholar
Kurebayashi Y, Nagai S, Ikejiri A, Ohtani M, Ichiyama K, Baba Y, et al. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma. Cell Rep. 2012;1:360–73.
Article CAS PubMed Google Scholar
Park HW, Lee HS. IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility. J Mol Med (Berl). 2024;102:129–42.
Article CAS PubMed Google Scholar
Tramutola A, Lanzillotta C, Barone E, Arena A, Zuliani I, Mosca L, et al. Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome. Transl Neurodegener. 2018;7:28.
Article CAS PubMed PubMed Central Google Scholar
Krakauer T, Buckley M. Intranasal rapamycin rescues mice from staphylococcal enterotoxin B-induced shock. Toxins (Basel). 2012;4:718–28.
Article CAS PubMed Google Scholar
Yoshioka M, Sagara H, Takahashi F, Harada N, Nishio K, Mori A, et al. Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2009;296:L30–6.
Article CAS PubMed Google Scholar
Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, et al. An Alternative Dendritic Cell-Induced Murine Model of Asthma exhibiting a robust Th2/Th17-Skewed response. Allergy Asthma Immunol Res. 2020;12:537–55.
Article CAS PubMed PubMed Central Google Scholar
Lee HS, Park HW. Role of mTOR in the development of Asthma in mice with cigarette smoke-Induced Cellular Senescence. J Gerontol Biol Sci Med Sci. 2022;77:433–42.
Sauter M, Sauter RJ, Nording H, Olbrich M, Emschermann F, Langer HF. Protocol to isolate and analyze mouse bone marrow derived dendritic cells (BMDC). STAR Protoc. 2022;3:101664.
Article CAS PubMed PubMed Central Google Scholar
Lambrecht BN, Hammad H, Fahy JV. Cytokines. Asthma Immun. 2019;50:975–91.
Zhang X, Chang Li X, Xiao X, Sun R, Tian Z, Wei H. CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. PLoS ONE. 2013;8:e77322.
Article CAS PubMed PubMed Central Google Scholar
McMillan SJ, Sharma RS, McKenzie EJ, Richards HE, Zhang J, Prescott A, et al. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling. Blood. 2013;121:2084–94.
Article CAS PubMed PubMed Central Google Scholar
Loffredo LF, Coden ME, Jeong BM, Walker MT, Anekalla KR, Doan TC, et al. Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development. Sci Rep. 2020;10:4425.
Article CAS PubMed PubMed Central Google Scholar
Hirahara K, Kokubo K, Aoki A, Kiuchi M, Nakayama T. The role of CD4(+) Resident Memory T cells in local immunity in the mucosal tissue - protection Versus Pathology. Front Immunol. 2021;12:616309.
Article CAS PubMed PubMed Central Google Scholar
Caccamo N, Joosten SA, Ottenhoff THM, Dieli F. Atypical human effector/memory CD4(+) T cells with a naive-like phenotype. Front Immunol. 2018;9:2832.
Article PubMed PubMed Central Google Scholar
Fukunaga J, Abe M, Murai A, Akitake Y, Hosokawa M, Takahashi M. Comparative study to elucidate the mechanism underlying the difference in airway hyperresponsiveness between two mouse strains. Int Immunopharmacol. 2007;7:1852–61.
Article CAS PubMed Google Scholar
Blacquiere MJ, Hylkema MN, Postma DS, Geerlings M, Timens W, Melgert BN. Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females. Int Arch Allergy Immunol. 2010;153:173–81.
Article CAS PubMed Google Scholar
Chen Z, Pan J, Jia Y, Li D, Min Z, Su X, et al. Effect of memory CD4(+) T cells’ signal transducer and activator of transcription (STATs) functional shift on cytokine-releasing properties in asthma. Cell Biol Toxicol. 2017;33:27–39.
Article CAS PubMed Google Scholar
Turner DL, Goldklang M, Cvetkovski F, Paik D, Trischler J, Barahona J, et al. Biased generation and in situ activation of lung tissue-resident memory CD4 T cells in the pathogenesis of allergic asthma. J Immunol. 2018;200:1561–9.
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