The role of celastrol in inflammation and diseases

Weiss U. Inflamm Nat. 2008;454(7203):427.

CAS  Google Scholar 

Zhou P. Traditional Chinese medicine. Comb Chem High Throughput Screen. 2010;13(10):836.

Article  CAS  PubMed  Google Scholar 

Morita T. Celastrol: a new therapeutic potential of traditional Chinese medicine. Am J Hypertens. 2010;23(8):821.

Article  PubMed  Google Scholar 

Lin MW, et al. Celastrol inhibits dopaminergic neuronal death of parkinson’s disease through activating mitophagy. Antioxid (Basel). 2019;9(1):37.

Article  Google Scholar 

Liu J, et al. Treatment of obesity with celastrol. Cell. 2015;161(5):999–1011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nanjundaiah SM, et al. Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk. J Biol Chem. 2012;287(26):22216–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saber S, et al. Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats. Toxicol Appl Pharmacol. 2020;400:115075.

Article  CAS  PubMed  Google Scholar 

You D, et al. Celastrol attenuates the inflammatory response by inhibiting IL-1β expression in triple–negative breast cancer cells. Oncol Rep. 2021;45(6):89.

Article  Google Scholar 

Zhang W et al. Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease. Autophagy. 2022;18(7):1740–2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wagh PR, et al. Nanotechnology-based celastrol formulations and their therapeutic applications. Front Pharmacol. 2021;12:673209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Afshin A, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27.

Article  PubMed  Google Scholar 

World Health O. World health statistics 2024: monitoring health for the SDGs, sustainable development goals. Geneva: World Health Organization. 2024.

Google Scholar 

Swinburn BA, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378(9793):804–14.

Article  PubMed  Google Scholar 

Yilmaz E. Endoplasmic reticulum stress and obesity. Adv Exp Med Biol. 2017;960:261–76.

Article  CAS  PubMed  Google Scholar 

Feng X, et al. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. Nat Med. 2019;25(4):575–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abu Bakar MH, et al. Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes. Eur J Pharmacol. 2017;799:73–83.

Article  CAS  PubMed  Google Scholar 

Abu Bakar MH, et al. Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways. Eur J Pharmacol. 2020;883:173371.

Article  CAS  PubMed  Google Scholar 

Luo D, et al. Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-kappaB pathways. Aging. 2017;9(10):2069–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu W, et al. Effects of microbiota on the treatment of obesity with the natural product celastrol in rats. Diabetes Metab J. 2020;44(5):747–63.

Article  PubMed  PubMed Central  Google Scholar 

Yang X, et al. Celastrol alleviates metabolic disturbance in high-fat diet-induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation. Phytother Res. 2021;35(1):297–310.

Article  CAS  PubMed  Google Scholar 

Zhu Y, et al. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice. Acta Pharm Sin B. 2021;11(5):1200–12.

Article  CAS  PubMed  Google Scholar 

Abu Bakar MH, et al. Celastrol attenuates high-fructose diet-induced inflammation and insulin resistance via inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues. BioFactors. 2022;48(1):111–34.

Article  CAS  PubMed  Google Scholar 

Luo D, et al. Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice. Elife. 2022;11:e72182.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, et al. Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes. Front Pharmacol. 2023;14:1094584.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao J, et al. Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice. J Control Release. 2019;310:188–97.

Article  CAS  PubMed  Google Scholar 

Fan N, et al. Biodegradable celastrol-loaded albumin nanoparticles ameliorate inflammation and lipid accumulation in diet-induced obese mice. Biomater Sci. 2022;10(4):984–96.

Article  CAS  PubMed  Google Scholar 

Xian J, et al. N-Trimethylated chitosan coating white adipose tissue vascular-targeting oral nano-system for the enhanced anti-obesity effects of celastrol. Int J Biol Macromol. 2023;236:124023.

Article  CAS  PubMed  Google Scholar 

Zhan X, et al. Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway. Mol Immunol. 2018;104:61–8.

Article  CAS  PubMed  Google Scholar 

Sun Z, et al. Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation. Cell Death Discov. 2019;5:114.

Article  PubMed  PubMed Central  Google Scholar 

Ma L, et al. Celastrol mitigates high glucose-induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR-345-5p/growth arrest-specific 6. J Gene Med. 2020;22(9):e3201.

Article  CAS  PubMed  Google Scholar 

Ouyang M, et al. Enhanced inflammatory reaction and thrombosis in high-fat diet-fed ApoE-/- mice are attenuated by Celastrol. Exp Clin Endocrinol Diabetes. 2021;129(5):339–48.

Article  CAS  PubMed  Google Scholar 

Bian J, et al. Celastrol confers ferroptosis resistance via AKT/GSK3beta signaling in high-fat diet-induced cardiac injury. Free Radic Biol Med. 2023;200:36–46.

Article  CAS  PubMed  Google Scholar 

Harris ED Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med. 1990;322(18):1277–89.

Article  PubMed 

Comments (0)

No login
gif