Salvianolic acid B inhibits the growth and metastasis of A549 lung cancer cells through the NDRG2/PTEN pathway by inducing oxidative stress

Zhu X, Chen L, Liu L, Niu X. EMT-mediated acquired EGFR-TKI resistance in NSCLC: mechanisms and strategies. Front Oncol. 2019;9:1044.

Article  PubMed  PubMed Central  Google Scholar 

Singh T, Fatehi Hassanabad M, Fatehi Hassanabad A. Non-small cell lung cancer: emerging molecular targeted and immunotherapeutic agents. Biochim Biophys Acta. 2021;1876(2):188636.

CAS  Google Scholar 

Wakabayashi H, Arai H, Inui A. The regulatory approval of anamorelin for treatment of cachexia in patients with non-small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer in Japan: facts and numbers. J Cachexia Sarcopenia Muscle. 2021;12(1):14–6.

Article  PubMed  Google Scholar 

Wang M, Herbst RS, Boshoff C. Toward personalized treatment approaches for non-small-cell lung cancer. Nat Med. 2021;27(8):1345–56.

Article  CAS  PubMed  Google Scholar 

Satia JA, Littman A, Slatore CG, Galanko JA, White E. Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and lifestyle study. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1419–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cassileth BR, Deng GE, Gomez JE, Johnstone PA, Kumar N, Vickers AJ, American College of Chest Physicians. Complementary therapies and integrative oncology in lung cancer: ACCP evidence-based clinical practice guidelines. Chest. 2007;132(3):340S-354S.

Article  PubMed  Google Scholar 

Sharma M, Pandey R, Saluja D. ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans. Autophagy. 2018;14(7):1239–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao Q, Lin M, Wang Y, Lai Y, Hu J, Fu T, Wang L, Lin S, Chen L, Guo Y. Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways. Int J Mol Med. 2015;36(4):1118–26.

Article  PubMed  Google Scholar 

Zuo Z, He L, Duan X, Peng Z, Han J. Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition. Bioengineered. 2022;13(2):2720–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shahzadi I, Ali Z, Bukhari S, Narula AS, Mirza B, Mohammadinejad R. Possible applications of salvianolic acid B against different cancers. Explor Target Antitumor Ther. 2020;1(4):218–38.

Article  PubMed  PubMed Central  Google Scholar 

Xiao Z, Liu W, Mu YP, Zhang H, Wang XN, Zhao CQ, Chen JM, Liu P. Pharmacological effects of salvianolic acid B against oxidative damage. Front Pharmacol. 2020;11:572373.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katary MA, Abdelsayed R, Alhashim A, Abdelhasib M, Elmarakby AA. Salvianolic acid B slows the progression of breast cancer cell growth via enhancement of apoptosis and reduction of oxidative stress, inflammation, and angiogenesis. Int J Mol Sci. 2019;20:5653.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao Y, Xie T, Korotcov A, Zhou Y, Pang X, Shan L, Ji H, Sridhar R, Wang P, Califano J, Gu X. Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. Int J Cancer. 2009;124:2200–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Huang C, Zhang Y, Tang X, Li S, Wang Q, Lin Y. Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells. Oncol Lett. 2020;20:817–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jing Z, Fei W, Zhou J, Zhang L, Chen L, Zhang X, Liang X, Xie J, Fang Y, Sui X, et al. Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells. Oncotarget. 2016;7:61509–19.

Article  PubMed  PubMed Central  Google Scholar 

Qin T, Rasul A, Sarfraz A, Sarfraz I, Hussain G, Anwar H, Riaz A, Liu S, Wei W, Li J, Li X. Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways. Int J Biol Sci. 2019;15:2256–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katary MA, Abdelsayed R, Alhashim A, Abdelhasib M, Elmarakby AA. Salvianolic acid B slows the progression of breast cancer cell growth via enhancement of apoptosis and reduction of oxidative stress, inflammation, and angiogenesis. Int J Mol Sci. 2019;20(22):5653.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han G, Wang Y, Liu T, Gao J, Duan F, Chen M, Yang Y, Wu C. Salvianolic acid B acts against non-small cell lung cancer A549 cells via inactivation of the MAPK and Smad2/3 signaling pathways. Mol Med Rep. 2022;25(5):184.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao L, Wang S, Zhao Y, Sheng X, Wang A, Zheng S, Lu Y. Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity. Phytomedicine. 2014;21:1473–82.

Article  CAS  PubMed  Google Scholar 

Ma J, Wu K, Liu K, Miao R. Effects of MALAT1 on proliferation and apoptosis of human non-small cell lung cancer A549 cells in vitro and tumor xenograft growth in vivo by modulating autophagy. Cancer Biomark. 2018;22:63–72.

Article  CAS  PubMed  Google Scholar 

Han YH, Mun JG, Jeon HD, Kee JY, Hong SH. betulin inhibits lung metastasis by inducing cell cycle arrest, autophagy, and apoptosis of metastatic colorectal cancer cells. Nutrients. 2019;12:66.

Article  PubMed  PubMed Central  Google Scholar 

Azad AK, Rajaram MV, Metz WL, Cope FO, Blue MS, Vera DR, Schlesinger LS. γ-Tilmanocept, a new radiopharmaceutical tracer for cancer sentinel lymph nodes, binds to the mannose receptor (CD206). J Immunol. 2015;195(5):2019–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang T, Gao W, Lin S, Chen H, Du B, Liu Q, Lin X, Chen Q. FNDC1 promotes the invasiveness of gastric cancer via Wnt/β-catenin signaling pathway and correlates with peritoneal metastasis and prognosis. Front Oncol. 2020;10:590492.

Article  PubMed  PubMed Central  Google Scholar 

Singh R, Manna PP. Reactive oxygen species in cancer progression and its role in therapeutics. Explor Med. 2022;3:43.

Article  CAS  Google Scholar 

Qian C, Yang C, Tang Y, Zheng W, Zhou Y, Zhang S, et al. Pharmacological manipulation of Ezh2 with salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy. Pharmacol Res. 2022;182:106333.

Article  CAS  PubMed  Google Scholar 

Srivastava N, Saxena AK. Caspase-3 activators as anticancer agents. Curr Protein Pept Sci. 2023;24(10):783–804.

Article  CAS  PubMed  Google Scholar 

da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE, Zuardi AW, Crippa JAS, Schröder N. Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. Transl Psychiatry. 2018;8(1):176.

Article  PubMed  PubMed Central  Google Scholar 

Guo SS, Wang ZG. Salvianolic acid B from Salvia miltiorrhiza bunge: a potential antitumor agent. Front Pharmacol. 2022;13:1042745.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim G, Lim S, Kim KD. N-myc downstream-regulated gene 2 (NDRG2) function as a positive regulator of apoptosis: a new insight into NDRG2 as a tumor suppressor. Cells. 2021;10(10):2649.

Article 

Comments (0)

No login
gif