Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63.

PubMed  Google Scholar 

Wang FH, et al. The Chinese society of clinical oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023. Cancer Commun (Lond). 2024;44(1):127–72.

Article  CAS  PubMed  Google Scholar 

Jin X, et al. Recent progress and future perspectives of immunotherapy in advanced gastric cancer. Front Immunol. 2022;13:948647.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thrift AP, Wenker TN, El-Serag HB. Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention. Nat Rev Clin Oncol. 2023;20(5):338–49.

Article  PubMed  Google Scholar 

Thrift AP, El-Serag HB. Burden of gastric cancer. Clin Gastroenterol Hepatol. 2020;18(3):534–42.

Article  PubMed  Google Scholar 

Zhang X, et al. Multifaceted functions of protein kinase D in pathological processes and human diseases. Biomolecules. 2021;11(3):483.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sánchez-Ruiloba L, et al. Protein kinase D intracellular localization and activity control kinase D-interacting substrate of 220-kDa traffic through a postsynaptic density-95/discs large/zonula occludens-1-binding motif. J Biol Chem. 2006;281(27):18888–900.

Article  PubMed  Google Scholar 

Kunkel MT, et al. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem. 2009;284(36):24653–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rey O, et al. Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists. J Biol Chem. 2003;278(26):23773–85.

Article  CAS  PubMed  Google Scholar 

Legay C, et al. Protein kinase D1 overexpression potentiates epidermal growth factor signaling pathway in MCF-7 cells. Mol Biol Rep. 2023;50(4):3641–51.

Article  CAS  PubMed  Google Scholar 

Feng R, et al. Knockdown of PRKD2 enhances chemotherapy sensitivity in cervical cancer via the TP53/CDKN1A pathway. Curr Cancer Drug Targets. 2023;23(2):159–70.

Article  CAS  PubMed  Google Scholar 

Cui B, et al. PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling. Int J Oral Sci. 2021;13(1):8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang B, He Z. Protein kinase D1 correlates with less lymph node metastasis risk, enhanced 5-fu sensitivity, and better prognosis in colorectal cancer. Tohoku J Exp Med. 2023;260(4):305–14.

Article  CAS  PubMed  Google Scholar 

Nickkholgh B, et al. Protein kinase D1 induces G1-phase cell-cycle arrest independent of checkpoint kinases by phosphorylating cell division cycle phosphatase 25. Prostate. 2019;79(9):1053–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merzoug-Larabi M, et al. Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1. BMC Cancer. 2017;17(1):12.

Article  PubMed  PubMed Central  Google Scholar 

Azoitei N, et al. Protein kinase D2: a versatile player in cancer biology. Oncogene. 2018;37(10):1263–78.

Article  CAS  PubMed  Google Scholar 

Zhu Y, et al. Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma. Oncotarget. 2016;7(5):5327–41.

Article  PubMed  Google Scholar 

Zaragoza-Huesca D, et al. Identification of thrombosis-related genes in patients with advanced gastric cancer: Data from AGAMENON-SEOM registry. Biomedicines. 2022;10(1):148.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, et al. Protein kinase D3 promotes gastric cancer development through p65/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 activation of glycolysis. Exp Cell Res. 2019;380(2):188–97.

Article  CAS  PubMed  Google Scholar 

Kang D, Kim IH. Molecular mechanisms and potential rationale of immunotherapy in peritoneal metastasis of advanced gastric cancer. Biomedicines. 2022;10(6):1376.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roy A, et al. Protein kinase D signaling in cancer: A friend or foe? Biochim Biophys Acta Rev Cancer. 2017;1868(1):283–94.

Article  CAS  PubMed  Google Scholar 

Liu Y, et al. Inhibition lysosomal degradation of clusterin by protein kinase D3 promotes triple-negative breast cancer tumor growth. Adv Sci (Weinh). 2021;8(4):2003205.

Article  CAS  PubMed  Google Scholar 

Varga A, et al. Protein kinase D3 (PKD3) requires Hsp90 for stability and promotion of prostate cancer cell migration. Cells. 2023;12(2):212.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang H, et al. Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients. Clin Res Hepatol Gastroenterol. 2017;41(5):554–63.

Article  CAS  PubMed  Google Scholar 

Chen J, et al. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Cancer Res. 2008;68(10):3844–53.

Article  CAS  PubMed  Google Scholar 

Cui B, et al. Protein kinase D3 regulates the expression of the immunosuppressive protein, PD-L1, through STAT1/STAT3 signaling. Int J Oncol. 2020;56(4):909–20.

CAS  PubMed  PubMed Central  Google Scholar 

Chen J, et al. Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res. 2011;71(12):4280–91.

Article  CAS  PubMed  Google Scholar 

Roy A, et al. Protein kinase D2 and D3 promote prostate cancer cell bone metastasis by positively regulating Runx2 in a MEK/ERK1/2-dependent manner. Am J Pathol. 2023;193(5):624–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azuma K, et al. TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer. Proc Natl Acad Sci U S A. 2021. https://doi.org/10.1073/pnas.2100784118.

Article  PubMed  PubMed Central  Google Scholar 

Huck B, et al. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem. 2014;289(6):3138–47.

Article  CAS  PubMed  Google Scholar 

Orea-Soufi A, et al. FOXO transcription factors as therapeutic targets in human diseases. Trends Pharmacol Sci. 2022;43(12):1070–84.

Article  CAS  PubMed