Wood LD, Canto MI, Jaffee EM, et al. Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment. Gastroenterology. 2022;163(2):386–402. https://doi.org/10.1053/j.gastro.2022.03.056.
Chibaya L, DeMarco K, Lusi C, et al. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer. Sci Transl Med. 2024;16(762):eadj9366. https://doi.org/10.1126/scitrans-lmed.adj9366.
Article CAS PubMed PubMed Central Google Scholar
Yang N, Fan ZY, Sun SY, et al. Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation. Eur J Med Chem. 2023;5(261): 115857. https://doi.org/10.1016/j.ejmech.2023.115857.
Li J, Wang X, Huang Y, et al. Preliminary activity and safety results of KRAS G12C inhibitor glecirasib (JAB-21822) in patients with pancreatic cancer and other solid tumors. J Clin Oncol. 2024;42(3):604.
Yang J, Xu R, Wang C, et al. Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review. Cancer Commun (Lond). 2021;41(12):1257–74. https://doi.org/10.1002/cac2.12204.
Article CAS PubMed Google Scholar
Timar J, Kashofer K. Molecular epidemiology and diagnostics of KRAS mutations in human cancer. Cancer Metastasis Rev. 2020;39(4):1029–38. https://doi.org/10.1007/s10555-020-09915-5.
Article CAS PubMed PubMed Central Google Scholar
Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, et al. Pancreatic cancer: advances and challenges. Cell. 2023;186(8):1729–54. https://doi.org/10.1016/j.cell.2023.02.014.
Article CAS PubMed PubMed Central Google Scholar
Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. https://doi.org/10.3322/caac.21763.
Klomp JA, Klomp JE, Stalnecker CA, et al. Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers. Science. 2024;384(6700):eadk0775. https://doi.org/10.1126/science.adk0775.
Article CAS PubMed PubMed Central Google Scholar
Wang YF, Xu LS, Ling LJ, et al. Unraveling the CDK9/PP2A/ERK network in transcriptional pause release and complement activation in KRAS-mutant cancers. Adv Sci (Weinh). 2024;11(41): e2404926.
Yang J, Wang QL, Wang GN, et al. A pan-KRAS degrader for the treatment of KRAS-mutant cancers. Cell Discov. 2024;10(1):70. https://doi.org/10.1038/s41421-024-00699-4.
Article CAS PubMed PubMed Central Google Scholar
Hallin J, Bowcut V, Calinisan A, et al. Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor. Nat Med. 2022;28(10):2171–82. https://doi.org/10.1038/s41591-022-02007-7.
Article CAS PubMed Google Scholar
Kemp SB, Cheng N, Markosyan N, et al. Efficacy of a small-molecule inhibitor of KrasG12D in immunocompetent models of pancreatic cancer. Cancer Discov. 2023;13(2):298–311. https://doi.org/10.1158/2159-8290.
Article CAS PubMed Google Scholar
Tinsley SL, Chianis ERD, Shelley RA, et al. KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56alpha to initiate pancreatic cancer development. Oncogene. 2024. https://doi.org/10.1038/s41388-024-03196-w.
McDaid WJ, Wilson L, Adderley H, et al. The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer. Mol Cancer. 2024;23(1):253. https://doi.org/10.1186/s12943-024-02157-x.
Article CAS PubMed PubMed Central Google Scholar
Ullah R, Yin Q, Snell AH, et al. RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol. 2022;85:123–54. https://doi.org/10.1016/j.semcancer.2021.05.010.
Article CAS PubMed Google Scholar
Li Q, Li Z, Luo T, et al. Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy. Mol Biomed. 2022;3(1):47. https://doi.org/10.1186/s43556-022-00110-2.
Article CAS PubMed PubMed Central Google Scholar
Hamarsheh S, Groß O, Brummer T, et al. Immune modulatory effects of oncogenic KRAS in cancer. Nat Commun. 2020;11(1):5439. https://doi.org/10.1038/s41467-020-19288-6.
Article CAS PubMed PubMed Central Google Scholar
Lanman BA, Allen JR, Allen JG, et al. Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors. J Med Chem. 2020;63(1):52–65. https://doi.org/10.1021/acs.jmedchem.9b01180.
Article CAS PubMed Google Scholar
Dhillon S. Adagrasib: first approval. Drugs. 2023;83(3):275–85. https://doi.org/10.1007/s40265-023-01839-y.
Article CAS PubMed Google Scholar
Wang X, Allen S, Blake JF, et al. Identification of MRTX1133, a noncovalent, potent, and selective KRASG12D inhibitor. J Med Chem. 2022;65(4):3123–33. https://doi.org/10.1021/acs.jmedchem.1c01688.
Article CAS PubMed Google Scholar
Reck M, Carbone DP, Garassino M, et al. Targeting KRAS in non-small-cell lung cancer: recent progress and new approaches. Ann Oncol. 2021;32(9):1101–10. https://doi.org/10.1016/j.annonc.2021.06.001.
Article CAS PubMed Google Scholar
Ryan MB, Coker O, Sorokin A, et al. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy. Cell Rep. 2022;39(12): 110993. https://doi.org/10.1016/j.celrep.2022.110993.
Article CAS PubMed PubMed Central Google Scholar
Canon J, Rex K, Saiki AY, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575(7781):217–23. https://doi.org/10.1038/s41586-019-1694-1.
Article CAS PubMed Google Scholar
Prahallad A, Weiss A, Voshol H, et al. CRISPR screening identifies mechanisms of resistance to KRASG12C and SHP2 inhibitor combinations in non-small cell lung cancer. Cancer Res. 2023;83(24):4130–41. https://doi.org/10.1158/0008-5472.
Article PubMed PubMed Central Google Scholar
Buck SA, Koolen SL, Mathijssen RH, de Wit R, van Soest RJ. Cross-resistance and drug sequence in prostate cancer. Drug Resist Updat. 2021;56:100761. https://doi.org/10.1016/j.drup.2021.100761.
Article CAS PubMed Google Scholar
Amodio V, Yaeger R, Arcella P, et al. EGFR Blockade reverts resistance to KRASG12C inhibition in colorectal cancer. Cancer Discov. 2020;10(8):1129–39. https://doi.org/10.1158/2159-8290.CD-20-0187.
Article CAS PubMed PubMed Central Google Scholar
Misale S, Fatherree JP, Cortez E, et al. KRAS G12C NSCLC models are sensitive to direct targeting of KRAS in combination with PI3K inhibition. Clin Cancer Res. 2019;25(2):796–807. https://doi.org/10.1158/1078-0432.CCR-18-0368.
Article CAS PubMed Google Scholar
Song Y, Zhao M, Zhang H, et al. Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials. Pharmacol Ther. 2022;230: 107966.
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