Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, et al. Renal cell carcinoma. Nat Rev Dis Prim. 2017;3:17009.
Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, et al. Cabozantinib versus everolimus in advanced renal-cell carcinoma. N. Engl J Med. 2015;373:1814–23.
Article CAS PubMed PubMed Central Google Scholar
Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, et al. Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma. N. Engl J Med. 2021;384:829–41.
Article CAS PubMed PubMed Central Google Scholar
Buil-Bruna N, López-Picazo J-M, Martín-Algarra S, Trocóniz IF. Bringing model-based prediction to oncology clinical practice: a review of pharmacometrics principles and applications. Oncologist. 2016;21:220–32.
Schmidinger M, Danesi R, Jones R, McDermott R, Pyle L, Rini B, et al. Individualized dosing with axitinib: rationale and practical guidance. Future Oncol Lond Engl. 2018;14:861–75.
Lacy S, Nielsen J, Yang B, Miles D, Nguyen L, Hutmacher M. Population exposure-response analysis of cabozantinib efficacy and safety endpoints in patients with renal cell carcinoma. Cancer Chemother Pharm. 2018;81:1061–70.
Castellano D, Pablo Maroto J, Benzaghou F, Taguieva N, Nguyen L, Clary DO, et al. Exposure-response modeling of cabozantinib in patients with renal cell carcinoma: Implications for patient care. Cancer Treat Rev. 2020;89:102062.
Article CAS PubMed Google Scholar
Krens SD, van Erp NP, Groenland SL, Moes DJAR, Mulder SF, Desar IME, et al. Exposure-response analyses of cabozantinib in patients with metastatic renal cell cancer. BMC Cancer. 2022;22:228.
Article CAS PubMed PubMed Central Google Scholar
Cerbone L, Combarel D, Geraud A, Auclin E, Foulon S, Alves Costa Silva C, et al. Association of cabozantinib pharmacokinetics, progression and toxicity in metastatic renal cell carcinoma patients: results from a pharmacokinetics/pharmacodynamics study. ESMO Open. 2021;6:100312.
Article CAS PubMed PubMed Central Google Scholar
Lacy S, Yang B, Nielsen J, Miles D, Nguyen L, Hutmacher M. A population pharmacokinetic model of cabozantinib in healthy volunteers and patients with various cancer types. Cancer Chemother Pharm. 2018;81:1071–82.
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer Oxf Engl 1990. 2009;45:228–47.
Lacy SA, Miles DR, Nguyen LT. Clinical pharmacokinetics and pharmacodynamics of cabozantinib. Clin Pharmacokinet. 2017;56:477–91.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, et al. Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial. Lancet Oncol. 2016;17:917–27.
Article CAS PubMed Google Scholar
Albiges L, Fléchon A, Chevreau C, Topart D, Gravis G, Oudard S, et al. Real-world evidence of cabozantinib in patients with metastatic renal cell carcinoma: results from the CABOREAL Early Access Program. Eur J Cancer Oxf Engl 1990. 2021;142:102–11.
Mueller-Schoell A, Groenland SL, Scherf-Clavel O, van Dyk M, Huisinga W, Michelet R, et al. Therapeutic drug monitoring of oral targeted antineoplastic drugs. Eur J Clin Pharm. 2021;77:441–64.
Puisset F, Mseddi M, Mourey L, Pouessel D, Blanchet B, Chatelut E, et al. Therapeutic drug monitoring of tyrosine kinase inhibitors in the treatment of advanced renal cancer. Cancers. 2023;15:313.
Article CAS PubMed PubMed Central Google Scholar
Gan CL, Dudani S, Wells JC, Donskov F, Pal SK, Dizman N, et al. Cabozantinib real-world effectiveness in the first-through fourth-line settings for the treatment of metastatic renal cell carcinoma: results from the international metastatic renal cell carcinoma database consortium. Cancer Med. 2021;10:1212–21.
Article CAS PubMed PubMed Central Google Scholar
Krens SD, van Boxtel W, Uijen MJM, Jansman FGA, Desar IME, Mulder SF, et al. Exposure-toxicity relationship of cabozantinib in patients with renal cell cancer and salivary gland cancer. Int J Cancer. 2022;150:308–16.
Article CAS PubMed Google Scholar
Tran BD, Li J, Ly N, Faggioni R, Roskos L. Cabozantinib exposure-response analysis for the phase 3 CheckMate 9ER trial of nivolumab plus cabozantinib versus sunitinib in first-line advanced renal cell carcinoma. Cancer Chemother Pharm. 2023;91:179–89.
Corianò M, Giannarelli D, Scartabellati G, De Giorgi U, Brighi N, Fornarini G, et al. Tailoring treatment with cabozantinib or pazopanib in patients with metastatic renal cell carcinoma: does it affect outcome? Expert Rev Anticancer Ther. 2023;23:545–54.
Arrondeau J, Mir O, Boudou-Rouquette P, Coriat R, Ropert S, Dumas G, et al. Sorafenib exposure decreases over time in patients with hepatocellular carcinoma. Invest N. Drugs. 2012;30:2046–9.
Ozbey AC, Combarel D, Poinsignon V, Lovera C, Saada E, Mir O, et al. Population pharmacokinetic analysis of pazopanib in patients and determination of target AUC. Pharm Basel Switz. 2021;14:927.
Sharma A, Elias R, Christie A, Williams NS, Pedrosa I, Bjarnason GA, et al. Extended disease control with unconventional cabozantinib dose increase in metastatic renal cell carcinoma. Kidney Cancer Clifton Va. 2022;6:69–79.
Article CAS PubMed Google Scholar
Mir O, Touati N, Lia M, Litière S, Le Cesne A, Sleijfer S, et al. Impact of concomitant administration of gastric acid-suppressive agents and pazopanib on outcomes in soft-tissue sarcoma patients treated within the EORTC 62043/62072 trials. Clin Cancer Res J Am Assoc Cancer Res. 2019;25:1479–85.
Ha VH, Ngo M, Chu MP, Ghosh S, Sawyer MB, Chambers CR. Does gastric acid suppression affect sunitinib efficacy in patients with advanced or metastatic renal cell cancer? J Oncol Pharm Pr Publ Int Soc Oncol Pharm Pr. 2015;21:194–200.
Nguyen L, Holland J, Mamelok R, Laberge M-K, Grenier J, Swearingen D, et al. Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects. J Clin Pharm. 2015;55:1293–302.
Rassy E, Cerbone L, Auclin E, Benchimoll-Zouari A, Flippot R, Alves Costa Silva C, et al. The effect of concomitant proton pump inhibitor and cabozantinib on the outcomes of patients with metastatic renal cell carcinoma. Oncologist. 2021;26:389–96.
Article CAS PubMed PubMed Central Google Scholar
Buti S, Tommasi C, Scartabellati G, De Giorgi U, Brighi N, Rebuzzi SE, et al. The impact of proton-pump inhibitors administered with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma. Anticancer Drugs. 2023;34:178–86.
Article CAS PubMed Google Scholar
Lee C-H, Shen M-C, Tsai M-J, Chang J-S, Huang Y-B, Yang Y-H, et al. Proton pump inhibitors reduce the survival of advanced lung cancer patients with therapy of gefitinib or erlotinib. Sci Rep. 2022;12:7002.
Article CAS PubMed PubMed Central Google Scholar
McGregor B, Mortazavi A, Cordes L, Salabao C, Vandlik S, Apolo AB. Management of adverse events associated with cabozantinib plus nivolumab in renal cell carcinoma: a review. Cancer Treat Rev. 2022;103:102333.
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