Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer

Taieb J, Svrcek M, Cohen R, Basile D, Tougeron D, Phelip J-M. Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment. Eur J Cancer. 2022;175:136–57.

Article  CAS  PubMed  Google Scholar 

Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pagès C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960–4.

Article  CAS  PubMed  Google Scholar 

Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020;20:662–80.

Article  CAS  PubMed  Google Scholar 

Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 2005;23:609–18.

Article  CAS  PubMed  Google Scholar 

Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, et al. Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers. Br J Cancer. 2016;115:25–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tran B, Kopetz S, Tie J, Gibbs P, Jiang ZQ, Lieu CH, et al. Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer. 2011;117:4623–32.

Article  CAS  PubMed  Google Scholar 

Wensink GE, Elferink MAG, May AM, Mol L, Hamers PAH, Bakker SD, et al. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era. Br J Cancer. 2021;124:399–406.

Article  CAS  PubMed  Google Scholar 

Guinney J, Dienstmann R, Wang X, de Reynies A, Schlicker A, Soneson C, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21:1350–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, et al. Proteogenomic characterization of human colon and rectal cancer. Nature. 2014;513:382–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vasaikar S, Huang C, Wang X, Petyuk VA, Savage SR, Wen B, et al. Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities. Cell. 2019;177:1035–49.e19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee HO, Hong Y, Etlioglu HE, Cho YB, Pomella V, Van den Bosch B, et al. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat Genet. 2020;52:594–603.

Article  CAS  PubMed  Google Scholar 

Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, et al. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat Genet. 2022;54:963–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pages F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018;391:2128–39.

Article  PubMed  Google Scholar 

Punt CJ, Koopman M, Vermeulen L. From tumour heterogeneity to advances in precision treatment of colorectal cancer. Nat Rev Clin Oncol. 2017;14:235–46.

Article  CAS  PubMed  Google Scholar 

Biller LH, Schrag D. Diagnosis and treatment of metastatic colorectal cancer: a review. JAMA. 2021;325:669–85.

Article  CAS  PubMed  Google Scholar 

Sargent DJ, Marsoni S, Monges G, Thibodeau SN, Labianca R, Hamilton SR, et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol. 2010;28:3219–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kucukkose E, Wensink GE, Roelse CM, van Schelven SJ, Raats DAE, Boj SF, et al. Mismatch repair status in patient-derived colorectal cancer organoids does not affect intrinsic tumor cell sensitivity to systemic therapy. Cancers. 2021;13:5434.

Article  PubMed  PubMed Central  Google Scholar 

Wu T, Dai Y. Tumor microenvironment and therapeutic response. Cancer Lett. 2017;387:61–8.

Article  CAS  PubMed  Google Scholar 

Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov. 2015;5:43–51.

Article  CAS  PubMed  Google Scholar 

Khaliq AM, Erdogan C, Kurt Z, Turgut SS, Grunvald MW, Rand T, et al. Refining colorectal cancer classification and clinical stratification through a single-cell atlas. Genome Biol. 2022;23:113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021;184:4734–52.e20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin A, Zhang J, Luo P. Crosstalk between the MSI status and tumor microenvironment in colorectal cancer. Front Immunol. 2020;11:2039.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Isella C, Terrasi A, Bellomo SE, Petti C, Galatola G, Muratore A, et al. Stromal contribution to the colorectal cancer transcriptome. Nat Genet. 2015;47:312–9.

Article  CAS  PubMed  Google Scholar 

Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, et al. Stromal gene expression defines poor-prognosis subtypes in colorectal cancer. Nat Genet. 2015;47:320–9.

Article  CAS  PubMed  Google Scholar 

Andre T, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt C, et al. Pembrolizumab in microsatellite-instability-high advanced colorectal cancer. N Engl J Med. 2020;383:2207–18.

Article  CAS  PubMed  Google Scholar 

Baars MJD, Sinha N, Amini M, Pieterman-Bos A, van Dam S, Ganpat MMP, et al. MATISSE: a method for improved single cell segmentation in imaging mass cytometry. BMC Biol. 2021;19:99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berg S, Kutra D, Kroeger T, Straehle CN, Kausler BX, Haubold C, et al. ilastik: interactive machine learning for (bio)image analysis. Nat Methods. 2019;16:1226–32.

Article  CAS  PubMed  Google Scholar 

Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 2006;7:R100.

Article  PubMed  PubMed Central  Google Scholar 

Krijgsman D, Sinha N, Baars MJD, van Dam S, Amini M, Vercoulen Y. MATISSE: an analysis protocol for combining imaging mass cytometry with fluorescence microscopy to generate single-cell data. STAR Protoc. 2022;3:101034.

Article  CAS  PubMed  Google Scholar 

Levine JH, Simonds EF, Bendall SC, Davis KL, Amir el AD, Tadmor MD, et al. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell. 2015;162:184–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schraa SJ, Stelloo E, Laclé MM, Swennenhuis JF, Brosens LAA, Fijneman RJA, et al. Comparison of NTRK fusion detection methods in microsatellite-instability-high metastatic colorectal cancer. Virchows Arch. 2023;482:983–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seppälä TT, Böhm JP, Friman M, Lahtinen L, Väyrynen VM, Liipo TK, et al. Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer. Br J Cancer. 2015;112:1966–75.

Article  PubMed  PubMed Central  Google Scholar 

Bindea G, Mlecnik B, Galon J. Immune sunrise: from the immunome to the cancer immune landscape. Oncoimmunology. 2022;11:2019896.

Article  PubMed  PubMed Central  Google Scholar 

Egelston CA, Avalos C, Tu TY, Rosario A, Wang R, Solomon S, et al. Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients. JCI Insight. 2019;4:e130000.

Article  PubMed  PubMed Central  Google Scholar 

van Dam S, Baars MJD, Vercoulen Y. Multiplex tissue imaging: spatial revelations in the tumor microenvironment. Cancers. 2022;14:3170.

Article  PubMed 

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