Afghah Z, Chen X, Geiger JD (2019) Role of endolysosomes and inter-organellar signaling in brain disease. Neurobiol Dis 134:104670. https://doi.org/10.1016/j.nbd.2019.104670

CrossRef  CAS  Google Scholar 

Alam MS, Getz M, Haldar K (2016) Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-pick type C disease in a mouse model. Sci Transl Med 8(326):326ra323. https://doi.org/10.1126/scitranslmed.aad9407

CrossRef  CAS  Google Scholar 

Barkla BJ, Blumwald E (1991) Identification of a 170-kDa protein associated with the vacuolar Na+/H+ antiport of Beta vulgaris. Proc Natl Acad Sci U S A 88(24):11177–11181. https://doi.org/10.1073/pnas.88.24.11177

CrossRef  CAS  Google Scholar 

Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H (2015) Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimers Dement 11(6):718–726. https://doi.org/10.1016/j.jalz.2015.05.016

CrossRef  Google Scholar 

Ben Halima S, Mishra S, Raja KMP, Willem M, Baici A, Simons K, Brustle O, Koch P, Haass C, Caflisch A, Rajendran L (2016) Specific inhibition of beta-secretase processing of the Alzheimer disease amyloid precursor protein. Cell Rep 14(9):2127–2141. https://doi.org/10.1016/j.celrep.2016.01.076

CrossRef  CAS  Google Scholar 

Blumwald E, Poole RJ (1985) Na/H antiport in isolated tonoplast vesicles from storage tissue of Beta vulgaris. Plant Physiol 78(1):163–167. https://doi.org/10.1104/pp.78.1.163

CrossRef  CAS  Google Scholar 

Bowers K, Levi BP, Patel FI, Stevens TH (2000) The sodium/proton exchanger Nhx1p is required for endosomal protein trafficking in the yeast Saccharomyces cerevisiae. Mol Biol Cell 11(12):4277–4294. https://doi.org/10.1091/mbc.11.12.4277

CrossRef  CAS  Google Scholar 

Brett CL, Wei Y, Donowitz M, Rao R (2002) Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am J Physiol Cell Physiol 282(5):C1031–C1041. https://doi.org/10.1152/ajpcell.00420.2001

CrossRef  CAS  Google Scholar 

Brett CL, Donowitz M, Rao R (2005a) Evolutionary origins of eukaryotic sodium/proton exchangers. Am J Physiol Cell Physiol 288(2):C223–C239. https://doi.org/10.1152/ajpcell.00360.2004

CrossRef  CAS  Google Scholar 

Brett CL, Tukaye DN, Mukherjee S, Rao R (2005b) The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking. Mol Biol Cell 16(3):1396–1405. https://doi.org/10.1091/mbc.e04-11-0999

CrossRef  CAS  Google Scholar 

Brett CL, Kallay L, Hua Z, Green R, Chyou A, Zhang Y, Graham TR, Donowitz M, Rao R (2011) Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae. PLoS One 6(3):e17619. https://doi.org/10.1371/journal.pone.0017619

CrossRef  CAS  Google Scholar 

Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Fuchtbauer EM, Fuchtbauer A, Holtzman DM, Takagi J, Willnow TE (2014) Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer’s disease mutation. Sci Transl Med 6(223):223ra220. https://doi.org/10.1126/scitranslmed.3007747

CrossRef  CAS  Google Scholar 

Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC (2001) BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 4(3):233–234. https://doi.org/10.1038/85064

CrossRef  CAS  Google Scholar 

Caporaso GL, Gandy SE, Buxbaum JD, Greengard P (1992) Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci U S A 89(6):2252–2256. https://doi.org/10.1073/pnas.89.6.2252

CrossRef  CAS  Google Scholar 

Casey JR, Grinstein S, Orlowski J (2010) Sensors and regulators of intracellular pH. Nat Rev Mol Cell Biol 11(1):50–61. https://doi.org/10.1038/nrm2820

CrossRef  CAS  Google Scholar 

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM (2011) Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Transl Med 3(89):89ra57. https://doi.org/10.1126/scitranslmed.3002156

CrossRef  CAS  Google Scholar 

Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA (2000) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157(1):277–286. https://doi.org/10.1016/s0002-9440(10)64538-5

CrossRef  CAS  Google Scholar 

Chan CY, Prudom C, Raines SM, Charkhzarrin S, Melman SD, De Haro LP, Allen C, Lee SA, Sklar LA, Parra KJ (2012) Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). J Biol Chem 287(13):10236–10250. https://doi.org/10.1074/jbc.M111.321133

CrossRef  CAS  Google Scholar 

Chen Y, Durakoglugil MS, Xian X, Herz J (2010) ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci U S A 107(26):12011–12016. https://doi.org/10.1073/pnas.0914984107

CrossRef  Google Scholar 

Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM (2005) Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48(6):913–922. https://doi.org/10.1016/j.neuron.2005.10.028

CrossRef  CAS  Google Scholar 

Colacurcio DJ, Nixon RA (2016) Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev 32:75–88. https://doi.org/10.1016/j.arr.2016.05.004

CrossRef  CAS  Google Scholar 

Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261(5123):921–923. https://doi.org/10.1126/science.8346443

CrossRef  CAS  Google Scholar 

Cummings JL, Morstorf T, Zhong K (2014) Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther 6(4):37. https://doi.org/10.1186/alzrt269

CrossRef  Google Scholar 

Dang DK, Makena MR, Llongueras JP, Prasad H, Ko M, Bandral M, Rao R (2019) A Ca(2+)-ATPase regulates e-cadherin biogenesis and epithelial-mesenchymal transition in breast cancer cells. Mol Cancer Res 17(8):1735–1747. https://doi.org/10.1158/1541-7786.MCR-19-0070

CrossRef  CAS  Google Scholar 

Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79(3):447–460. https://doi.org/10.1016/j.neuron.2013.05.035

CrossRef  CAS  Google Scholar 

Deane EC, Ilie AE, Sizdahkhani S, Das Gupta M, Orlowski J, McKinney RA (2013) Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci 33(2):595–610. https://doi.org/10.1523/JNEUROSCI.2583-12.2013

CrossRef  CAS  Google Scholar 

Diering GH, Numata Y, Fan S, Church J, Numata M (2013) Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling. Mol Biol Cell 24(21):3435–3448. https://doi.org/10.1091/mbc.E12-06-0445

CrossRef  CAS  Google Scholar 

Donowitz M, Ming Tse C, Fuster D (2013) SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Asp Med 34(2–3):236–251. https://doi.org/10.1016/j.mam.2012.05.001

CrossRef  CAS  Google Scholar 

Esposito F, Sorosina M, Ottoboni L, Lim ET, Replogle JM, Raj T, Brambilla P, Liberatore G, Guaschino C, Romeo M, Pertel T, Stankiewicz JM, Martinelli V, Rodegher M, Weiner HL, Brassat D, Benoist C, Patsopoulos NA, Comi G, Elyaman W, Martinelli Boneschi F, De Jager PL (2015) A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity. Ann Neurol 78(1):115–127. https://doi.org/10.1002/ana.24429

CrossRef  CAS  Google Scholar 

Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ, Markenscoff-Papadimitriou E, Bear DM, Greenberg ME (2008) Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron 60(6):1022–1038. https://doi.org/10.1016/j.neuron.2008.11.029

CrossRef  CAS  Google Scholar 

Fuster DG, Alexander RT (2014) Traditional and emerging roles for the SLC9 Na+/H+ exchangers. Pflugers Arch 466(1):61–76. https://doi.org/10.1007/s00424-013-1408-8

CrossRef  CAS  Google Scholar 

Garai K, Baban B, Frieden C (2011) Self-association and stability of the ApoE isoforms at low pH: implications for ApoE-lipid interactions. Biochemistry 50(29):6356–6364. https://doi.org/10.1021/bi2006702

CrossRef  CAS  Google Scholar 

Garbern JY, Neumann M, Trojanowski JQ, Lee VM, Feldman G, Norris JW, Friez MJ, Schwartz CE, Stevenson R, Sima AA (2010) A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition. Brain 133(Pt 5):1391–1402. https://doi.org/10.1093/brain/awq071

CrossRef  Google Scholar 

Gaxiola RA, Rao R, Sherman A, Grisafi P, Alper SL, Fink GR (1999) The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast. Proc Natl Acad Sci U S A 96(4):1480–1485. https://doi.org/10.1073/pnas.96.4.1480

CrossRef  CAS  Google Scholar 

Gilfillan GD, Selmer KK, Roxrud I, Smith R, Kyllerman M, Eiklid K, Kroken M, Mattingsdal M, Egeland T, Stenmark H, Sjoholm H, Server A, Samuelsson L, Christianson A, Tarpey P, Whibley A, Stratton MR, Futreal PA, Teague J, Edkins S, Gecz J, Turner G, Raymond FL, Schwartz C, Stevenson RE, Undlien DE, Stromme P (2008) SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet 82(4):1003–1010. https://doi.org/10.1016/j.ajhg.2008.01.013

CrossRef  CAS  Google Scholar 

Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ (1995) The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. J Biol Chem 270(11):6186–6192. https://doi.org/10.1074/jbc.270.11.6186

CrossRef  CAS  Google Scholar 

Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME (2017) Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology. Acta Neuropathol 134(5):769–788. https://doi.org/10.1007/s00401-017-1737-3

CrossRef  CAS  Google Scholar 

Hauser MA, Li YJ, Xu H, Noureddine MA, Shao YS, Gullans SR, Scherzer CR, Jensen RV, McLaurin AC, Gibson JR, Scott BL, Jewett RM, Stenger JE, Schmechel DE, Hulette CM, Vance JM (2005) Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. Arch Neurol 62(6):917–921. https://doi.org/10.1001/archneur.62.6.917