Lynch SV, Pedersen O. The human intestinal microbiome in Health and Disease. N Engl J Med. 2016;375:2369–79.

Article  CAS  PubMed  Google Scholar 

Zhang L, Lu Q, Chang C. Epigenetics in Health and Disease. Adv Exp Med Biol. 2020;1253:3–55.

Article  CAS  PubMed  Google Scholar 

Nie P, Li Z, Wang Y, Zhang Y, Zhao M, Luo J, Du S, Deng Z, Chen J, Wang Y, et al. Gut microbiome interventions in human health and Diseases. Med Res Rev. 2019;39:2286–313.

Article  PubMed  Google Scholar 

Liu C, Du L, Wang S, Kong L, Zhang S, Li S, Zhang W, Du G. Differences in the prevention and control of cardiovascular and cerebrovascular Diseases. Pharmacol Res. 2021;170:105737.

Article  PubMed  Google Scholar 

Forte M, Schirone L, Ameri P, Basso C, Catalucci D, Modica J, Chimenti C, Crotti L, Frati G, Rubattu S, et al. The role of mitochondrial dynamics in Cardiovascular Diseases. Br J Pharmacol. 2021;178:2060–76.

Article  CAS  PubMed  Google Scholar 

Liberale L, Ministrini S, Carbone F, Camici GG, Montecucco F. Cytokines as therapeutic targets for cardio- and cerebrovascular Diseases. Basic Res Cardiol. 2021;116:23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vogel B, Acevedo M, Appelman Y, Bairey Merz CN, Chieffo A, Figtree GA, Guerrero M, Kunadian V, Lam CSP, Maas A, et al. The Lancet women and Cardiovascular Disease commission: reducing the global burden by 2030. Lancet. 2021;397:2385–438.

Article  PubMed  Google Scholar 

Sun L, Zhang H, Gao P. Metabolic reprogramming and epigenetic modifications on the path to cancer. Protein Cell. 2022;13:877–919.

Article  CAS  PubMed  Google Scholar 

Prasher D, Greenway SC, Singh RB. The impact of epigenetics on Cardiovascular Disease. Biochem Cell Biol. 2020;98:12–22.

Article  CAS  PubMed  Google Scholar 

Anzelon TA, Chowdhury S, Hughes SM, Xiao Y, Lander GC, MacRae IJ. Structural basis for piRNA targeting. Nature. 2021;597:285–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Fejes Tóth K, Aravin AA. piRNA Biogenesis in Drosophila melanogaster. Trends Genet. 2017;33:882–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pippadpally S, Venkatesh T. Deciphering piRNA biogenesis through cytoplasmic granules, mitochondria and exosomes. Arch Biochem Biophys. 2020;695:108597.

Article  CAS  PubMed  Google Scholar 

Genzor P, Konstantinidou P, Stoyko D, Manzourolajdad A, Marlin Andrews C, Elchert AR, Stathopoulos C, Haase AD. Cellular abundance shapes function in piRNA-guided genome defense. Genome Res. 2021;31:2058–68.

Article  PubMed  PubMed Central  Google Scholar 

Ozata DM, Gainetdinov I, Zoch A, O’Carroll D, Zamore PD. PIWI-interacting RNAs: small RNAs with big functions. Nat Rev Genet. 2019;20:89–108.

Article  CAS  PubMed  Google Scholar 

Parhad SS, Theurkauf WE. Rapid evolution and conserved function of the piRNA pathway. Open Biol. 2019;9:180181.

Article  CAS  PubMed  Google Scholar 

Iwasaki YW, Siomi MC, Siomi H. PIWI-Interacting RNA: its Biogenesis and functions. Annu Rev Biochem. 2015;84:405–33.

Article  CAS  PubMed  Google Scholar 

Zeng Q, Wan H, Zhao S, Xu H, Tang T, Oware KA, Qu S. Role of PIWI-interacting RNAs on cell survival: proliferation, apoptosis, and cycle. IUBMB Life. 2020;72:1870–8.

Article  CAS  PubMed  Google Scholar 

Tóth KF, Pezic D, Stuwe E, Webster A. The piRNA Pathway guards the germline genome against transposable elements. Adv Exp Med Biol. 2016;886:51–77.

Article  PubMed  PubMed Central  Google Scholar 

Wang K, Wang T, Gao XQ, Chen XZ, Wang F, Zhou LY. Emerging functions of piwi-interacting RNAs in Diseases. J Cell Mol Med. 2021;25:4893–901.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Wong G. An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative Diseases. Transl Neurodegener. 2021;10:9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang K, Zhou LY, Liu F, Lin L, Ju J, Tian PC, Liu CY, Li XM, Chen XZ, Wang T, et al. PIWI-Interacting RNA HAAPIR regulates Cardiomyocyte Death after Myocardial Infarction by promoting NAT10-Mediated ac(4) C acetylation of Tfec mRNA. Adv Sci (Weinh). 2022;9:e2106058.

Article  PubMed  Google Scholar 

Liu Y, Dou M, Song X, Dong Y, Liu S, Liu H, Tao J, Li W, Yin X, Xu W. The emerging role of the piRNA/piwi complex in cancer. Mol Cancer. 2019;18:123.

Article  PubMed  PubMed Central  Google Scholar 

Ramat A, Simonelig M. Functions of PIWI proteins in Gene Regulation: new arrows added to the piRNA Quiver. Trends Genet. 2021;37:188–200.

Article  CAS  PubMed  Google Scholar 

Lin Y, Zheng J, Lin D. PIWI-interacting RNAs in human cancer. Semin Cancer Biol. 2021;75:15–28.

Article  CAS  PubMed  Google Scholar 

Mokarram P, Niknam M, Sadeghdoust M, Aligolighasemabadi F, Siri M, Dastghaib S, Brim H, Ashktorab H. PIWI interacting RNAs perspectives: a new avenues in future cancer investigations. Bioengineered. 2021;12:10401–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Ben S, Xin J, Li S, Zheng R, Wang H, Fan L, Du M, Zhang Z, Wang M. The biogenesis and biological function of PIWI-interacting RNA in cancer. J Hematol Oncol. 2021;14:93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Tu S, Stubna M, Wu WS, Huang WC, Weng Z, Lee HC. The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes. Science. 2018;359:587–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan C, Muliyil S, Rao BJ. Genome damage sensing leads to tissue homeostasis in Drosophila. Int Rev Cell Mol Biol. 2019;345:173–224.

Article  PubMed  Google Scholar 

Lupski JR, Liu P, Stankiewicz P, Carvalho CMB, Posey JE. Clinical genomics and contextualizing genome variation in the diagnostic laboratory. Expert Rev Mol Diagn. 2020;20:995–1002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goga A, Stoffel M. Therapeutic RNA-silencing oligonucleotides in metabolic Diseases. Nat Rev Drug Discov. 2022;21:417–39.

Article  CAS  PubMed  Google Scholar 

Henney NC, Banach M, Penson PE. RNA silencing in the management of Dyslipidemias. Curr Atheroscler Rep. 2021;23:69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Czech B, Munafò M, Ciabrelli F, Eastwood EL, Fabry MH, Kneuss E, Hannon GJ. piRNA-Guided Genome Defense: from Biogenesis to silencing. Annu Rev Genet. 2018;52:131–57.

Article  CAS  PubMed  Google Scholar 

Wilson RC, Doudna JA. Molecular mechanisms of RNA interference. Annu Rev Biophys. 2013;42:217–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gebert D, Neubert LK, Lloyd C, Gui J, Lehmann R, Teixeira FK. Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation. Mol Cell. 2021;81:3965–3978e3965.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kofler R. Dynamics of transposable element invasions with piRNA clusters. Mol Biol Evol. 2019;36:1457–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu T, Fan K, Özata DM, Zhang G, Fu Y, Theurkauf WE, Zamore PD, Weng Z. Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes. Nat Commun. 2021;12:73.

Article  CAS  PubMed