Michel PP, Hirsch EC, Hunot S. Understanding dopaminergic cell death pathways in Parkinson disease. Neuron. 2016;90(4):675–91.
Article CAS PubMed Google Scholar
Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol. 2010;11(4):301–7.
Article CAS PubMed PubMed Central Google Scholar
Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, et al. Targeting α-synuclein for treatment of Parkinson’s disease: mechanistic and therapeutic considerations. Lancet Neurol. 2015;14(8):855–66.
Article CAS PubMed PubMed Central Google Scholar
Hirsch EC, Hunot S. Neuroinflammation in Parkinson’s disease: a target for neuroprotection? Lancet Neurol. 2009;8(4):382–97.
Article CAS PubMed Google Scholar
Lim S, Chun Y, Lee JS, Lee S-J. Neuroinflammation in synucleinopathies. Brain Pathol. 2016;26(3):404–9.
Article PubMed PubMed Central Google Scholar
Panicker N, Sarkar S, Harischandra DS, Neal M, Kam T-I, Jin H, et al. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. J Exp Med. 2019;216(6):1411–30.
Article CAS PubMed PubMed Central Google Scholar
Scheiblich H, Bousset L, Schwartz S, Griep A, Latz E, Melki R, et al. Microglial NLRP3 inflammasome activation upon TLR2 and TLR5 ligation by distinct α-synuclein assemblies. J Immunol. 2021;207(8):2143–54.
Article CAS PubMed PubMed Central Google Scholar
Scheiblich H, Dansokho C, Mercan D, Schmidt SV, Bousset L, Wischhof L, et al. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell. 2021;184(20):5089–106.
Article CAS PubMed PubMed Central Google Scholar
Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein, et al. Structural and functional characterization of two alpha-synuclein strains. Nat Commun. 2013;4(1):2575.
Article ADS PubMed Google Scholar
Gribaudo S, Tixador P, Bousset L, Fenyi A, Lino P, Melki R, et al. Propagation of α-synuclein strains within human reconstructed neuronal network. Stem Cell Rep. 2019;12(2):230–44.
Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, et al. Differential membrane binding and seeding of distinct α-synuclein fibrillar polymorphs. Biophys J. 2020;118(6):1301–20.
Article CAS PubMed PubMed Central Google Scholar
Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, et al. α-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature. 2015;522(7556):340–4.
Article ADS CAS PubMed Google Scholar
Rey NL, Bousset L, George S, Madaj Z, Meyerdirk L, Schulz E, et al. α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb. Acta Neuropathol Commun. 2019;7(1):221.
Article CAS PubMed PubMed Central Google Scholar
Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, et al. The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies. Acta Neuropathol. 2020;139(6):977–1000.
Article PubMed PubMed Central Google Scholar
Landureau M, Redeker V, Bellande T, Eyquem S, Melki R. The differential solvent exposure of N-terminal residues provides “fingerprints” of alpha-synuclein fibrillar polymorphs. J Biol Chem. 2021;296: 100737.
Article CAS PubMed PubMed Central Google Scholar
Song S-Y, Kim I-S, Koppula S, Park J-Y, Kim B-W, Yoon S-H, et al. 2-Hydroxy-4-methylbenzoic anhydride inhibits neuroinflammation in cellular and experimental animal models of Parkinson’s disease. Int J Mol Sci. 2020;21(21):8195.
Article CAS PubMed PubMed Central Google Scholar
Tu D, Gao Y, Yang R, Guan T, Hong J-S, Gao H-M. The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration. J Neuroinflamm. 2019;16(1):1–17.
Perry VH, Nicoll JAR, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol. 2010;6(4):193–201.
Chiu IM, Morimoto ETA, Goodarzi H, Liao JT, O’Keeffe S, Phatnani HP, et al. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013;4(2):385–401.
Article CAS PubMed PubMed Central Google Scholar
Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity. 2014;40(2):274–88.
Article CAS PubMed PubMed Central Google Scholar
Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, et al. A validated regulatory network for Th17 cell specification. Cell. 2012;151(2):289–303.
Article CAS PubMed PubMed Central Google Scholar
Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA. 1997;94(15):8093–8.
Article ADS CAS PubMed PubMed Central Google Scholar
Popov A, Abdullah Z, Wickenhauser C, Saric T, Driesen J, Hanisch F-G, et al. Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J Clin Invest. 2006;116(12):3160–70.
Article CAS PubMed PubMed Central Google Scholar
Reiling N, Hölscher C, Fehrenbach A, Kröger S, Kirschning CJ, Goyert S, et al. Cutting edge: toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol. 2002;169(7):3480–4.
Article CAS PubMed Google Scholar
Shay JES, Celeste SM. Hypoxia-inducible factors: crosstalk between inflammation and metabolism. Sem Cell Dev Biol. 2012;23(4):389–94.
Doorn KJ, Moors T, Drukarch B, van de Berg WD, Lucassen PJ, van Dam A-M. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients. Acta Neuropathol Commun. 2014;2(1):90.
PubMed PubMed Central Google Scholar
Mogi M, Harada M, Riederer P, Narabayashi H, Fujita K, Nagatsu T. Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett. 1994;165(1–2):208–10.
Article CAS PubMed Google Scholar
Teismann P, Tieu K, Choi D-K, Wu D-C, Naini A, Hunot S, et al. Cyclooxygenase-2 is instrumental in Parkinson’s disease neurodegeneration. Proc Natl Acad Sci USA. 2003;100(9):5473–8.
Article ADS CAS PubMed PubMed Central Google Scholar
Sepulveda-Diaz JE, Ouidja MO, Socias SB, Hamadat S, Guerreiro S, Raisman-Vozari R, et al. A simplified approach for efficient isolation of functional microglial cells: application for modeling neuroinflammatory responses in vitro: simplified approach for microglia isolation. Glia. 2016;64(11):1912–24.
Tourville A, Akbar D, Corti O, Prehn JHM, Melki R, Hunot S, et al. Modelling α-synuclein aggregation and neurodegeneration with fibril seeds in primary cultures of mouse dopaminergic neurons. Cells. 2022;11(10):1640.
Article CAS PubMed PubMed Central Google Scholar
Pozzi D, Ban J, Iseppon F, Torre V. An improved method for growing neurons: comparison with standard protocols. J Neurosci Methods. 2017;15(280):1–10.
Rook GAW, Steele J, Umar S, Dockrell HM. A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by γ-interferon. J Immunol Methods. 1985;82(1):161–7.
Article CAS PubMed Google Scholar
Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.
Article PubMed PubMed Central Google Scholar
Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform. 2013;14(1):128.
Comments (0)