Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49.
Nasim F, Sabath BF, Eapen GA. Lung cancer. Med Clin N Am. 2019;103(3):463–73.
Lemjabbar-Alaoui H, Hassan OU, Yang YW, Buchanan P. Lung cancer: biology and treatment options. Biochim Biophys Acta. 2015;1856(2):189–210.
CAS PubMed PubMed Central Google Scholar
Zhu X, Yu Z, Feng L, Deng L, Fang Z, Liu Z, et al. Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer. Carbohydr Polym. 2021;268:118237.
Article CAS PubMed Google Scholar
Fukushi A, Kim HD, Chang YC, Kim CH. Revisited metabolic control and reprogramming cancers by means of the Warburg effect in tumor cells. Int J Mol Sci. 2022;23(17):10037.
Article CAS PubMed PubMed Central Google Scholar
Kang H, Kim B, Park J, Youn H, Youn B. The Warburg effect on radioresistance: survival beyond growth. Biochim Biophys Acta Rev Cancer. 2023;1878(6): 188988.
Article CAS PubMed Google Scholar
Liao M, Yao D, Wu L, Luo C, Wang Z, Zhang J, et al. Targeting the Warburg effect: a revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer. Acta Pharm Sin B. 2024;14(3):953–1008.
Article CAS PubMed Google Scholar
Spencer NY, Stanton RC. The Warburg effect, lactate, and nearly a century of trying to cure cancer. Semin Nephrol. 2019;39(4):380–93.
Article CAS PubMed Google Scholar
Rabinowitz JD, Enerbäck S. Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020;2(7):566–71.
Article CAS PubMed PubMed Central Google Scholar
Qian J, Gong ZC, Zhang YN, Wu HH, Zhao J, Wang LT, et al. Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer. Cell Commun Signal. 2021;19(1):9.
Article CAS PubMed PubMed Central Google Scholar
Zhang A, Xu Y, Xu H, Ren J, Meng T, Ni Y, et al. Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17. Theranostics. 2021;11(8):3839–52.
Article CAS PubMed PubMed Central Google Scholar
Han X, Du S, Chen X, Min X, Dong Z, Wang Y, et al. Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer. Theranostics. 2023;13(7):2368–83.
Article CAS PubMed PubMed Central Google Scholar
Wang X, Liu H, Ni Y, Shen P, Han X. Lactate shuttle: from substance exchange to regulatory mechanism. Hum Cell. 2022;35(1):1–14.
Article CAS PubMed Google Scholar
Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, et al. Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis. Cancer Res. 2014;74(3):908–20.
Article CAS PubMed Google Scholar
Zhang G, Zhang Y, Dong D, Wang F, Ma X, Guan F, et al. MCT1 regulates aggressive and metabolic phenotypes in bladder cancer. J Cancer. 2018;9(14):2492–501.
Article PubMed PubMed Central Google Scholar
Miranda-Gonçalves V, Gonçalves CS, Granja S, Vieira de Castro J, Reis RM, Costa BM, et al. MCT1 is a new prognostic biomarker and its therapeutic inhibition boosts response to temozolomide in human glioblastoma. Cancers (Basel). 2021;13(14):3468.
Li M, Long X, Wan H, Yin M, Yang B, Zhang F, et al. Monocarboxylate transporter 1 promotes proliferation and invasion of renal cancer cells by mediating acetate transport. Cell Biol Int. 2021;45(6):1278–87.
Article CAS PubMed Google Scholar
Romero-Cordoba SL, Rodriguez-Cuevas S, Bautista-Pina V, Maffuz-Aziz A, D’Ippolito E, Cosentino G, et al. Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer. Sci Rep. 2018;8(1):12252.
Article PubMed PubMed Central Google Scholar
Fan Q, Yang L, Zhang X, Ma Y, Li Y, Dong L, et al. Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2018;37(1):9.
Article PubMed PubMed Central Google Scholar
Tao Z, Huang C, Wang D, Wang Q, Gao Q, Zhang H, et al. Lactate induced mesenchymal stem cells activation promotes gastric cancer cells migration and proliferation. Exp Cell Res. 2023;424(1):113492.
Article CAS PubMed Google Scholar
Silva A, Cerqueira MC, Rosa B, Sobral C, Pinto-Ribeiro F, Costa MF, et al. Prognostic value of monocarboxylate transporter 1 overexpression in cancer: a systematic review. Int J Mol Sci. 2023;24(6):5141.
Article CAS PubMed PubMed Central Google Scholar
Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, et al. Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract. J Ethnopharmacol. 2014;152(1):190–200.
Article CAS PubMed Google Scholar
Moon MK, Kang DG, Lee JK, Kim JS, Lee HS. Vasodilatory and anti-inflammatory effects of the aqueous extract of rhubarb via a NO-cGMP pathway. Life Sci. 2006;78(14):1550–7.
Article CAS PubMed Google Scholar
Zeng Y, Liu X, Yi Q, Qiao G, Wang L, Chen L, et al. Free total rhubarb anthraquinones protect intestinal mucosal barrier of SAP rats via inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway. J Ethnopharmacol. 2024;326:117873.
Article CAS PubMed Google Scholar
Huang H, Liu Z, Qi X, Gao N, Chang J, Yang M, et al. Rhubarb granule promotes diethylnitrosamine-induced liver tumorigenesis by activating the oxidative branch of pentose phosphate pathway via G6PD in rats. J Ethnopharmacol. 2021;281:114479.
Article CAS PubMed Google Scholar
Semwal RB, Semwal DK, Combrinck S, Viljoen A. Emodin—a natural anthraquinone derivative with diverse pharmacological activities. Phytochemistry. 2021;190:112854.
Article CAS PubMed Google Scholar
Chen S, Zhang Z, Zhang J. Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo. Drug Des Devel Ther. 2019;13:1145–53.
Article CAS PubMed PubMed Central Google Scholar
Zhang FY, Li RZ, Xu C, Fan XX, Li JX, Meng WY, et al. Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa. Phytomedicine. 2022;95:153786.
Article CAS PubMed Google Scholar
Su J, Yan Y, Qu J, Xue X, Liu Z, Cai H. Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway. Oncol Rep. 2017;37(3):1565–72.
Xiao D, Hu Y, Fu Y, Wang R, Zhang H, Li M, et al. Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle. Phytomedicine. 2019;59:152758.
Comments (0)