Alleviating effect of antioxidants on combined chromium and cadmium-induced neurotoxicity and apoptosis by activating the Nrf2-keap1 and associated pathway in albino mice

Aebi H (1974) Catalase. Methods of enzymatic analysis, Second Edition edn. Academic. https://doi.org/10.1016/B978-0-12-091302-2.50032-3

Aldhahri RS, Alghamdi BS, Alzahrani NA, Bahaidrah KA, Alsufiani HM, Mansouri RA, Ashraf GM (2022) Biochanin A improves memory decline and brain pathology in cuprizone-induced mouse model of multiple sclerosis. Behav Sci (Basel) 12. https://doi.org/10.3390/bs12030070

Althagafy HS et al (2024) Quetiapine attenuates cadmium neurotoxicity by suppressing oxidative stress, inflammation, and pyroptosis. Mol Biol Rep 51:660. https://doi.org/10.1007/s11033-024-09558-7

Article  CAS  PubMed  Google Scholar 

Atici S et al (2004) Opioid neurotoxicity: comparison of morphine and tramadol in an experimental rat model. Int J Neurosci 114:1001–1011. https://doi.org/10.1080/00207450490461314

Article  CAS  PubMed  Google Scholar 

Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK (2020) Heavy metals exposure and Alzheimer’s disease and related dementias. J Alzheimers Dis 76:1215–1242. https://doi.org/10.3233/JAD-200282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee N et al (2008) Arsenic-induced mitochondrial instability leading to programmed cell death in the. Exposed Individuals Toxicol 246:101–111. https://doi.org/10.1016/j.tox.2007.12.029

Article  CAS  Google Scholar 

Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302–310. https://doi.org/10.1016/s0076-6879(78)52032-6

Article  CAS  PubMed  Google Scholar 

Chang HC, Guarente L (2014) SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab 25:138–145. https://doi.org/10.1016/j.tem.2013.12.001

Article  CAS  PubMed  Google Scholar 

Chou SH et al (2023) Cadmium exposure induces histological damage and cytotoxicity in the cardiovascular system of mice. Food Chem Toxicol 175:113740. https://doi.org/10.1016/j.fct.2023.113740

Article  CAS  PubMed  Google Scholar 

Dan G, Lall SB, Rao DN (2000) Humoral and cell mediated immune response to cadmium in mice. Drug Chem Toxicol 23:349–360. https://doi.org/10.1081/dct-100100120

Article  CAS  PubMed  Google Scholar 

Daniel S, Limson JL, Dairam A, Watkins GM, Daya S (2004) Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 98:266–275. https://doi.org/10.1016/j.jinorgbio.2003.10.014

Article  CAS  PubMed  Google Scholar 

Dashti A, Soodi M, Amani N (2016) Cr (VI) induced oxidative stress and toxicity in cultured cerebellar granule neurons at different stages of development and protective effect of Rosmarinic acid. Environ Toxicol 31:269–277. https://doi.org/10.1002/tox.22041

Article  CAS  PubMed  Google Scholar 

Dong C (2015) Protective effect of proanthocyanidins in cadmium induced neurotoxicity in mice. Drug Res (Stuttg) 65:555–560. https://doi.org/10.1055/s-0034-1395544

Article  CAS  PubMed  Google Scholar 

El-Demerdash FM, Yousef MI, Elaswad FA (2006) Biochemical study on the protective role of folic acid in rabbits treated with chromium (VI). J Environ Sci Health B 41:731–746. https://doi.org/10.1080/03601230600704282

Article  CAS  PubMed  Google Scholar 

Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77. https://doi.org/10.1016/0003-9861(59)90090-6

Article  CAS  PubMed  Google Scholar 

Ellman GL, Courtney KD, Andres V Jr., Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95. https://doi.org/10.1016/0006-2952(61)90145-9

Article  CAS  PubMed  Google Scholar 

Fan SR, Ren TT, Yun MY, Lan R, Qin XY (2021) Edaravone attenuates cadmium-induced toxicity by inhibiting oxidative stress and inflammation in ICR mice. Neurotoxicology 86:1–9. https://doi.org/10.1016/j.neuro.2021.06.003

Article  CAS  PubMed  Google Scholar 

Ghafoor N, Mehar T, Batool M, Salar MZ, Ahmed MZ, Atique U (2024) Attenuative effects of poncirin against polyethylene microplastics-prompted hepatotoxicity in rats. J King Saud University-Science 36:103475

Google Scholar 

Goncalves JF et al (2012) Behavior and brain enzymatic changes after long-term intoxication with cadmium salt or contaminated potatoes. Food Chem Toxicol 50:3709–3718. https://doi.org/10.1016/j.fct.2012.07.016

Article  CAS  PubMed  Google Scholar 

Guilhermino L, Soares AM, Carvalho AP, Lopes MC (1998) Correlation between whole blood cholinesterase activity and cerebral cortex cholinesterase activity in rats treated with parathion. Chemosphere 37:1385–1393. https://doi.org/10.1016/s0045-6535(98)00129-5

Article  CAS  PubMed  Google Scholar 

Guo M et al (2019) Biochanin A provides neuroprotection against cerebral ischemia/reperfusion injury by Nrf2-mediated inhibition of oxidative stress and inflammation signaling pathway in rats. Med Sci Monit 25:8975–8983. https://doi.org/10.12659/MSM.918665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130–7139

CAS  PubMed  Google Scholar 

Halder S, Kar R, Chakraborty S, Banerjee BD (2021) Chromium exposure in late gestation period caused increased levels of cr in brain tissue: association with alteration of activity and gene expression of antioxidant enzymes of F1 and F2 generation mice. Biol Trace Elem Res 199:2635–2643. https://doi.org/10.1007/s12011-020-02367-6

Article  CAS  PubMed  Google Scholar 

Han B et al (2019) Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1alpha/Nrf2. Pathw Food Funct 10:5555–5565. https://doi.org/10.1039/c9fo01152h

Article  CAS  Google Scholar 

Hu ML (1994) Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 233:380–385. https://doi.org/10.1016/s0076-6879(94)33044-1

Article  CAS  PubMed  Google Scholar 

Hu Z, Nie G, Luo J, Hu R, Li G, Hu G, Zhang C (2023) Molybdenum and cadmium co-induce pyroptosis via inhibiting Nrf2-Mediated antioxidant defense response in the brain of ducks. Biol Trace Elem Res 201:874–887. https://doi.org/10.1007/s12011-022-03170-1

Article  CAS  PubMed  Google Scholar 

Itoh K, Tong KI, Yamamoto M (2004) Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36:1208–1213. https://doi.org/10.1016/j.freeradbiomed.2004.02.075

Article  CAS  PubMed  Google Scholar 

Jin Y, Zhang S, Tao R, Huang J, He X, Qu L, Fu Z (2016) Oral exposure of mice to cadmium (II), chromium (VI) and their mixture induce oxidative- and endoplasmic reticulum-stress mediated apoptosis in the livers. Environ Toxicol 31:693–705. https://doi.org/10.1002/tox.22082

Article  CAS  PubMed  Google Scholar 

Kaygusuzoglu E, Caglayan C, Kandemir FM, Yildirim S, Kucukler S, Kilinc MA, Saglam YS (2018) Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats. Biomed Pharmacother 102:517–530. https://doi.org/10.1016/j.biopha.2018.03.119

Article  CAS  PubMed  Google Scholar 

Levine RL et al (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464–478. https://doi.org/10.1016/0076-6879(90)86141-h

Article  CAS  PubMed  Google Scholar 

Lian CY, Chu BX, Xia WH, Wang ZY, Fan RF, Wang L (2023) Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy. J Adv Res 46:87–100. https://doi.org/10.1016/j.jare.2022.04.016

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