Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery

Kaur G, Singh SK, Kumar R, Kumar B, Kumari Y, Gulati M, et al. Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis. J Drug Deliv Sci Technol. 2020. https://doi.org/10.1016/j.jddst.2020.101980.

Article  Google Scholar 

Mohanta S, Singh SK, Kumar B, Gulati M, Kumar R, Yadav AK, et al. Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis. Int J Biol Macromol. 2019;126:427–35. https://doi.org/10.1016/j.ijbiomac.2018.12.154.

Article  PubMed  CAS  Google Scholar 

McCoubrey LE, Favaron A, Awad A, Orlu M, Gaisford S, Basit AW. Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics. J Control Release. 2023;353:1107–26. https://doi.org/10.1016/j.jconrel.2022.12.029.

Article  PubMed  CAS  Google Scholar 

Philip AK, Philip B. Colon targeted drug delivery systems: a review on primary and novel approaches. Oman Med J. 2010. https://doi.org/10.5001/2Fomj.2010.24.

Article  PubMed  PubMed Central  Google Scholar 

Ibrahim IM. Advances in polysaccharide-based oral colon-targeted delivery systems: the journey so far and the road ahead. Cureus. 2023. https://doi.org/10.7759/cureus.33636.

Article  PubMed  PubMed Central  Google Scholar 

Chatterjee S, Corrie L, Hanmantrao M, Vishwas S, Kumar R, Alotaibi F, et al. Quality by design-oriented formulation optimization and characterization of guar gum-pectin based oral colon targeted liquisolid formulation of xanthohumol. J Drug Deliv Sci Technol. 2023;82: 104350. https://doi.org/10.1016/j.jddst.2023.104350.

Article  CAS  Google Scholar 

Hanmantrao M, Chaterjee S, Kumar R, Vishwas S, Harish V, Porwal O, et al. Development of guar gum-pectin-based colon targeted solid self-nanoemulsifying drug delivery system of xanthohumol. Pharmaceutics. 2022. https://doi.org/10.3390/pharmaceutics14112384.

Article  PubMed  PubMed Central  Google Scholar 

Jyoti J, Anandhakrishnan NK, Singh SK, Kumar B, Gulati M, Gowthamarajan K, et al. A three-pronged formulation approach to improve oral bioavailability and therapeutic efficacy of two lipophilic drugs with gastric lability. Drug Deliv Transl Res. 2019;9:848–65. https://doi.org/10.1007/s13346-019-00635-0.

Article  PubMed  CAS  Google Scholar 

Zhou C, Huang Y, Nie S, Zhou S, Gao X, Chen G. Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent. Eur J Med Res. 2023;28:297. https://doi.org/10.1186/s40001-023-01271-8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dong W, Jia C, Li J, Zhou Y, Luo Y, Liu J, et al. Fisetin attenuates diabetic nephropathy-induced podocyte injury by inhibiting NLRP3 inflammasome. Front Pharmacol. 2022. https://doi.org/10.3389/2Ffphar.2022.783706.

Article  PubMed  PubMed Central  Google Scholar 

Kumar R, Kumar R, Khurana N, Singh SK, Khurana S, Verma S, et al. Improved neuroprotective activity of Fisetin through SNEDDS in ameliorating the behavioral alterations produced in rotenone-induced Parkinson’s model. Environ Sci Pollut Res. 2022;29(33):50488–99. https://doi.org/10.1007/s11356-022-19428-z.

Article  CAS  Google Scholar 

Shanmugam K, Ravindran S, Kurian GA, Rajesh M. Fisetin confers cardioprotection against myocardial ischemia reperfusion injury by suppressing mitochondrial oxidative stress and mitochondrial dysfunction and inhibiting glycogen synthase kinase 3 β activity. Oxid Med Cell Longev. 2018;25:9173436. https://doi.org/10.1155/2018/9173436.

Article  CAS  Google Scholar 

Ren Q, Tao S, Guo F, Wang B, Yang L, Ma L, et al. Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling. Phytomedicine. 2021;87: 153552. https://doi.org/10.1016/j.phymed.2021.153552.

Article  PubMed  CAS  Google Scholar 

Vishwas S, Singh SK, Gulati M, Awasthi A, Khursheed R, Corrie L, et al. Harnessing the therapeutic potential of fisetin and its nanoparticles: Journey so far and road ahead. Chem Biol Interact. 2022;356: 109869. https://doi.org/10.1016/j.cbi.2022.109869.

Article  PubMed  CAS  Google Scholar 

Sahu BD, Kumar JM, Sistla R. Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling. J Nutr Biochem. 2016;28:171–82. https://doi.org/10.1016/j.jnutbio.2015.10.004.

Article  PubMed  CAS  Google Scholar 

Wang C, Xiang Y, Ma W, Guo C, Wu X. Therapeutic potential evaluation of silk sericin stabilized fisetin to ulcerative colitis. Macromol Biosci. 2024;24:2300277. https://doi.org/10.1002/mabi.202300277.

Article  CAS  Google Scholar 

Ashiqueali SA, Chaudhari D, Zhu X, Noureddine S, Siddiqi S, Garcia DN, et al. Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis. GeroScience. 2024;46:3085–103. https://doi.org/10.1007/s11357-024-01060-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li L, Wang M, Yang H, Li Y, Huang X, Guo J, et al. Fisetin inhibits trypsin activity and suppresses the growth of colorectal cancer in vitro and in vivo. Nat Prod Commun. 2022. https://doi.org/10.1177/1934578X221115511.

Article  Google Scholar 

Suh Y, Afaq F, Johnson JJ, Mukhtar H. A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-κB-signaling pathways. Carcinogenesis. 2009;30:300–7. https://doi.org/10.1093/2Fcarcin%2Fbgn269.

Article  PubMed  CAS  Google Scholar 

Vishwas S, Gulati M, Kapoor B, Gupta S, Singh SK, Awasthi A, et al. Expanding the arsenal against Huntington’s disease-Herbal drugs and their nanoformulations. Curr Neuropharmacol. 2021;19:957–89. https://doi.org/10.2174/1570159x18666201109090824.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khursheed R, Singh SK, Gulati M, Wadhwa S, Kapoor B, Pandey NK, et al. Exploring role of polysaccharides present in Ganoderma lucidium extract powder and probiotics as solid carriers in development of liquisolid formulation loaded with quercetin: A novel study. Int J Biol Macromol. 2021;183:1630–9. https://doi.org/10.1016/j.ijbiomac.2021.05.064.

Article  PubMed  CAS  Google Scholar 

Khursheed R, Singh SK, Kumar B, Wadhwa S, Gulati M, Anupriya A, et al. Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin-induced rats. Int J Pharm. 2022. https://doi.org/10.1016/j.ijpharm.2021.121306.

Article  PubMed  Google Scholar 

Khursheed R, Singh SK, Wadhwa S, Gulati M, Awasthi A, Kumar R, et al. Exploring role of probiotics and Ganoderma lucidum extract powder as solid carriers to solidify liquid self-nanoemulsifying delivery systems loaded with curcumin. Carbohydr Polym. 2020;250: 116996.

Article  PubMed  CAS  Google Scholar 

Ghosh D, Singh SK, Khursheed R, Pandey NK, Kumar B, Kumar R, et al. Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid. Drug Dev Ind Pharm Taylor & Francis. 2020. https://doi.org/10.1080/03639045.2020.1742143.

Article  Google Scholar 

Pandya P, Pandey NK, Singh SK, Kumar M. Formulation and characterization of ternary complex of poorly soluble duloxetine hydrochloride. J Appl Pharm Sci. 2015;5:88–96. https://doi.org/10.7324/JAPS.2015.50615.

Article  CAS  Google Scholar 

Kumar B, Singh SK, Prakash T, Bhatia A, Gulati M, Garg V, et al. Pharmacokinetic and pharmacodynamic evaluation of Solid self-nanoemulsifying delivery system (SSNEDDS) loaded with curcumin and duloxetine in attenuation of neuropathic pain in rats. Neurol Sci. 2020;42:1785–97. https://doi.org/10.1007/s10072-020-04628-7.

Article  PubMed  Google Scholar 

Pandey NK, Singh SK, Gulati M, Kumar B, Kapoor B, Ghosh D, et al. Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of glimepiride and simvastatin co-delivered in the form of nanosuspension and solid self-nanoemulsifying drug delivery system: A comparative study. J Drug Deliv Sci Technol. 2020;60: 102083. https://doi.org/10.1016/j.jddst.2020.102083.

Article  CAS  Google Scholar 

Kassem AA, Abd El-Alim SH, Salman AM, Mohammed MA, Hassan NS, El-Gengaihi SE. Improved hepatoprotective activity of Beta vulgaris L. leaf extract loaded self-nanoemulsifying drug delivery system (SNEDDS): in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2020;46:1589–603. https://doi.org/10.1080/0363904520201811303.

Comments (0)

No login
gif