The role of Tmem119 in the estrogen action on bone in mice

Khosla S, Monroe DG (2018) Regulation of bone metabolism by sex steroids. Cold Spring Harb Perspect Med 8:a031211

Article  PubMed  PubMed Central  Google Scholar 

Almeida M, Laurent MR, Dubois V, Claessens F, O’Brien CA, Bouillon R, Vanderschueren D, Manolagas SC (2017) Estrogens and androgens in skeletal physiology and pathophysiology. Physiol Rev 97:135–187

Article  PubMed  Google Scholar 

Emmanuelle NE, Marie-Cecile V, Florence T, Jean-Francois A, Francoise L, Coralie F, Alexia V (2021) Critical role of estrogens on bone homeostasis in both male and female: from physiology to medical implications. Int J Mol Sci 22:1568

Article  PubMed  Google Scholar 

Manolagas SC (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31:266–300

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kaji H, Sugimoto T, Kanatani M, Nasu M, Chihara K (1996) Estrogen blocks parathyroid hormone (PTH)-stimulated osteoclast-like cell formation by selectively affecting PTH-responsive cyclic adenosine monophosphate pathway. Endocrinology 137:2217–2224

Article  PubMed  CAS  Google Scholar 

Kanatani M, Sugimoto T, Takahashi Y, Kaji H, Kitazawa R, Chihara K (1998) Estrogen via the estrogen receptor blocks cAMP-mediated parathyroid hormone (PTH)-stimulated osteoclast formation. J Bone Miner Res 13:854–862

Article  PubMed  CAS  Google Scholar 

Meng X, Lin Z, Cao S, Janowska I, Sonomoto K, Andreev D, Katharina K, Wen J, Knaup KX, Wiesener MS, Kronke G, Rizzi M, Schett G, Bozec A (2022) Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss. Bone Res 10:15

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu Z, Lee HL, Suh JS, Deng P, Lee CR, Bezouglaia O, Mirnia M, Chen V, Zhou M, Cui ZK, Kim RH, Lee M, Aghaloo T, Hong C, Wang CY (2022) The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells. Bone Res 10:3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H (2011) Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. J Biol Chem 286:9787–9796

Article  PubMed  PubMed Central  CAS  Google Scholar 

Calabrese G, Bennett BJ, Orozco L, Kang HM, Eskin E, Dombret C, De Backer O, Lusis AJ, Farber CR (2012) Systems genetic analysis of osteoblast-lineage cells. PLoS Genet 8:e1003150

Article  PubMed  PubMed Central  CAS  Google Scholar 

Doolittle M, Khosla S, Saul D (2023) Single-cell integration of BMD GWAS results prioritize candidate genes influencing age-related bone loss. JBMR Plus 7:e10795

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu M, Wang D, Li K, Ma T, Wang Y, Xia B (2024) TMEM119 (c.G143A, p. S48L) mutation is involved in primary failure of eruption by attenuating glycolysis-mediated osteogenesis. Int J Mol Sci 25:2821

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kawao N, Matsumura D, Yamada A, Okumoto K, Ohira T, Mizukami Y, Hashimoto D, Kaji H (2024) Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice. Bone 181:117040

Article  PubMed  CAS  Google Scholar 

Tanaka K, Inoue Y, Hendy GN, Canaff L, Katagiri T, Kitazawa R, Komori T, Sugimoto T, Seino S, Kaji H (2012) Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells. Bone 51:158–167

Article  PubMed  CAS  Google Scholar 

Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T (2014) Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cells. Calcif Tissue Int 94:454–464

Article  PubMed  CAS  Google Scholar 

Yang R, Li J, Zhang J, Xue Q, Qin R, Wang R, Goltzman D, Miao D (2023) 17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation. Free Radic Biol Med 195:231–244

Article  PubMed  CAS  Google Scholar 

Matsumura D, Kawao N, Yamada A, Okumoto K, Ohira T, Mizukami Y, Goto K, Kaji H (2024) Tmem119 deficiency delays bone repair in mice. Bone 186:117177

Article  PubMed  CAS  Google Scholar 

Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Muller R (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25:1468–1486

Article  PubMed  Google Scholar 

Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H (2013) Plasminogen plays a crucial role in bone repair. J Bone Miner Res 28:1561–1574

Article  PubMed  CAS  Google Scholar 

Moshi MR, Nicolopoulos K, Stringer D, Ma N, Jenal M, Vreugdenburg T (2023) The clinical effectiveness of denosumab (Prolia®) for the treatment of osteoporosis in postmenopausal women, compared to bisphosphonates, selective estrogen receptor modulators (SERM), and placebo: a systematic review and network meta-analysis. Calcif Tissue Int 112:631–646

Article  PubMed  CAS  Google Scholar 

Herrera-Quiterio GA, Encarnacion-Guevara S (2023) The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Front Oncol 13:1244740

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comments (0)

No login
gif