Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273–285

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang X, Ding Y, Sun L, Shi M, Zhang P, Huang Z, Wang J, He A, Wang J, Wei J et al (2022) Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling. Redox Biol 58:102555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zeng X, Lu D, Yin M, Shan M, Gao Y, Jin L (2021) Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod 36(4):951–964

Article  CAS  PubMed  Google Scholar 

Zhang Y, Hu M, Jia W, Liu G, Zhang J, Wang B, Li J, Cui P, Li X, Lager S et al (2021) Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats. J Endocrinol 246(2):247–263

Google Scholar 

Kagan VE, Mao G, Qu F, Angeli JPF, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB et al (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol 13(1):81–90

Article  CAS  PubMed  Google Scholar 

Wang M, Zhang BQ, Ma S, Xu Y, Zhao DH, Zhang JS, Li CJ, Zhou X, Zheng LW (2024) Broadening horizons: the role of ferroptosis in polycystic ovary syndrome. Front Endocrinol (Lausanne) 15:1390013

Article  PubMed  Google Scholar 

Adamska A, Łebkowska A, Krentowska A, Adamski M, Kowalska I (2019) The association between serum ferritin concentration and visceral adiposity estimated by whole-body DXA scan in women with polycystic ovary syndrome. Front Endocrinol (Lausanne) 10:873

Article  PubMed  Google Scholar 

Chen B, Zhao L, Yang R, Xu T (2023) The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer. Front Genet

Ward DM, Cloonan SM (2019) Mitochondrial iron in human health and disease. Annu Rev Physiol 81(1):453–482

Article  CAS  PubMed  Google Scholar 

Kawabata H (2019) Transferrin and transferrin receptors update. Free Radic Biol Med 133:46–54

Article  CAS  PubMed  Google Scholar 

Torti SV, Torti FM (2020) Iron and cancer: 2020 vision. Can Res 80(24):5435–5448

Article  CAS  Google Scholar 

Wu H, Liu Q, Shan,X, Gao W, Chen Q (2023) ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4. Autophagy

Yan N, Zhang J (2019) Iron metabolism, ferroptosis, and the links with Alzheimer’s disease. Front Neurosci 13:1443

Article  PubMed  Google Scholar 

Zhu T, Xiao Z, Yuan H-Y, Tian H, Chen T, Chen Q, Chen M, Yang J-K, Zhou Q, Guo W et al (2022) ACO1 and IREB2 downregulation confer poor prognosis and correlate with autophagy-related ferroptosis and immune infiltration in KIRC. Front Oncol 12

Li N, Wang W, Zhou H, Wu Q-Q, Duan M, Liu C, Wu H-M, Deng W, Shen D-F, Tang Q (2020) Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med

Santana-Codina N,Gikandi A, Mancias J (2021) The role of NCOA4-mediated ferritinophagy in ferroptosis. Adv Exp Med Biol

Santana-Codina N, del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, Poupault C, Kuljanin M, John KM, Biancur DE et al (2022) NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins. Cancer Discov 12(10):2180–2197

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo W, Zhao Y, Li H, Lei L (2021) NCOA4-mediated ferritinophagy promoted inflammatory responses in periodontitis. J Periodontal Res

Yang L, Liu Q, Lu Q, Xiao JJ, Fu AY, Wang S, Ni L, Hu JW, Yu H, Wu X et al (2024) Scavenger receptor class B type I deficiency induces iron overload and ferroptosis in renal tubular epithelial cells via hypoxia-inducible factor-1α/transferrin receptor 1 signaling pathway. Antioxid Redox Signal 41(1–3):56–73

Article  CAS  PubMed  Google Scholar 

Yan X, Xie Y, Liu H, Huang M, Yang Z, An D, Jiang G (2023) Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy. Diabetol Metab Syndr 15(1):161

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T et al (2018) Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell 172(3):409-422.e21

Article  CAS  PubMed  Google Scholar 

Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH et al (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575(7784):693–698

Article  CAS  PubMed  Google Scholar 

Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12(8):599–620

Article  CAS  PubMed  Google Scholar 

Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y, Vergely C (202) Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis. Int J Mol Sci

Yoo S, Bae J, Moon J, Koh G (2020) System χc- overexpression prevents 2-deoxy-d-ribose-induced β-cell damage. Free Radic Biol Med

Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H et al (2020) Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Investig 130(4):1752–1766

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chase L, Kleyn MV, Schiller N, King A, Flores G, Engelsman SB, Bowles C, Smith SL, Robinson A, Rothstein J (2019) Hydrogen peroxide triggers an increase in cell surface expression of system xc − in cultured human glioma cells. Neurochem Int 134

Wang F, Min J (2021) DHODH tangoing with GPX4 on the ferroptotic stage. Signal Transduct Target Ther 6(1):244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang F, Zhang G, An N, Dai Q, Cho W, Shang H, Xing Y (2024) Interplay of ferroptosis, cuproptosis, and PANoptosis in cancer treatment-induced cardiotoxicity: mechanisms and therapeutic implications. Semin Cancer Biol 106–107:106–122

Article  PubMed  Google Scholar 

Vučković A-M, Travain VB, Bordin L, Cozza G, Miotto G, Rossetto M, Toppo S, Venerando R, Zaccarin M, Maiorino M et al (2020) Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε. FEBS Lett 594

Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann A, Cai LL, Niehues M, Badock V et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol 16(5):497–506

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee H-J, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM et al (2020) Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368(6486):85–89

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Y, Kang R, Klionsky DJ, Tang D (2023) GPX4 in cell death, autophagy, and disease. Autophagy 19(10):2621–2638

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conrad M, Proneth B (2020) Selenium: tracing another essential element of ferroptotic cell death. Cell Chem Biol

Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ et al (2019) Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell 177(5):1262-1279.e25

Article  CAS  PubMed  Google Scholar 

Yang Z, Kang C, Wing Kak L, Jinzhao L, Weirong K, Yaming Z, Ranyao Y, Leigang J, Yiyun C, Aimin X et al (2023) Photo‐enhanced synergistic induction of ferroptosis for anti‐cancer immunotherapy. Adv Healthc Mater

Lee JY, Kim WK, Bae KH, Lee SC, Lee EW (2021) Lipid metabolism and ferroptosis. Biology 10(3)

Tang D, Kroemer G (2020) Peroxisome: the new player in ferroptosis. Signal Transduct Target Ther

Habaxi KK, Wang W, Taximaimaiti M, Wang X (2024) Methylation regulation of LPCAT3 improves osteoarthritis by regulating ACSL4 to inhibit chondrocyte ferroptosis. Crit Rev Eukaryot Gene Expr 34(2):77–86

Article  PubMed  Google Scholar 

Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK et al (2019) Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol 26(3):420-432.e9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shubhra M (2023) Ferroptosis signaling pathways: Alzheimer’s disease. Horm Metab Res

Fujii J, Yamada KI (2023) Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage. Free Radic Res 57:353–372

Article  CAS  PubMed  Google Scholar 

Wenzel SE, Tyurina YY, Zhao J, St. Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA et al (2017) PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell 171(3):628–641 (e26)