Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review

Al Rayes H, Abdulaziz S, Alotaibi AM, Alaithan MA, Attar M, Daghasi H, Melibari R, Althagafi AH, Elnady B (2021) Adverse impact of rheumatoid arthritis on pregnancy outcomes: a Saudi Arabia prospective multicenter study. Open Access Rheumatol Res Rev, 167–175

Anderka MT, Lin AE, Abuelo DN, Mitchell AA, Rasmussen SA (2009) Reviewing the evidence for mycophenolate mofetil as a new teratogen: case report and review of the literature. Am J Med Genet A 149(6):1241–1248. https://doi.org/10.1002/ajmg.a.32685

Article  Google Scholar 

Antonucci R, Zaffanello M, Puxeddu E, Porcella A, Cuzzolin L, Dolores Pilloni M, Fanos V (2012) Use of non-steroidal anti-inflammatory drugs in pregnancy: impact on the fetus and newborn. Curr Drug Metab 13(4):474–490. https://doi.org/10.2174/138920012800166607

Article  CAS  PubMed  Google Scholar 

Baerts W, Fetter WPF, Hop WCJ, Wallenburg HCS, Spritzer R, Sauer PJJ (1990) Cerebral lesions in preterm infants after tocolytic indomethacin. Dev Med Child Neurol 32(10):910–918. https://doi.org/10.1111/j.1469-8749.1990.tb08104.x

Article  CAS  PubMed  Google Scholar 

Banhidy F, Acs N, Puhó EH, Czeizel AE (2011) Chronic hypertension with related drug treatment of pregnant women and congenital abnormalities in their offspring: a population-based study. Hypertens Res 34(2):257–263. https://doi.org/10.1038/hr.2010.227

Article  PubMed  Google Scholar 

Barrett JH, Brennan P, Fiddler M, Silman AJ (1999) Does rheumatoid arthritis remit during pregnancy and relapse postpartum?: Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy. Arthritis Rheumatism 42(6):1219–1227. https://doi.org/10.1002/1529-0131(199906)42:6%3C1219::AID-ANR19%3E3.0.CO;2-G

Article  CAS  PubMed  Google Scholar 

Bharti B, Lee SJ, Lindsay SP, Wingard DL, Jones KL, Lemus H, Chambers CD (2015) Disease severity and pregnancy outcomes in women with rheumatoid arthritis: results from the organization of teratology information specialists autoimmune diseases in pregnancy project. J Rheumatol 42(8):1376–1382. https://doi.org/10.3899/jrheum.140583

Article  PubMed  Google Scholar 

Bizzaro N, Bartoloni E, Morozzi G, Manganelli S, Riccieri V, Sabatini P, Filippini M, Tampoia M, Afeltra A, Sebastiani G, Alpini C (2013) Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study. Arthritis Res Ther 15:1–9. https://doi.org/10.1186/ar4148

Article  CAS  Google Scholar 

Borrero CG, Mountz JM, Mountz JD (2011) Emerging MRI methods in rheumatoid arthritis. Nat Rev Rheumatol 7(2):85–95. https://doi.org/10.1038/nrrheum.2010.173

Article  PubMed  Google Scholar 

Bowden AP, Barrett JH, Fallow WENDY, Silman AJ (2001) Women with inflammatory polyarthritis have babies of lower birth weight. J Rheumatol 28(2):355–359

CAS  PubMed  Google Scholar 

Bröms G, Granath F, Ekbom A, Hellgren K, Pedersen L, Sørensen HT, Stephansson O, Kieler H (2016) Low risk of birth defects for infants whose mothers are treated with anti-Tumor Necrosis Factor agents during pregnancy. Clin Gastroenterol Hepatol 14(2):234–241. https://doi.org/10.1016/j.cgh.2015.08.039

Article  CAS  PubMed  Google Scholar 

Brouwer J, Laven JS, Hazes JM, Dolhain RJ (2015) Brief report: miscarriages in female rheumatoid arthritis patients: associations with serologic findings, disease activity, and antirheumatic drug treatment. Arthritis & Rheumatology 67(7):1738–1743. https://doi.org/10.1002/art.39137

Article  CAS  Google Scholar 

Burmester GR, Dimitriu-Bona A, Waters SJ, Winchester RJ (1983) Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts. Scand J Immunol 17(1):69–82. https://doi.org/10.1111/j.1365-3083.1983.tb00767.x

Article  CAS  PubMed  Google Scholar 

Carmichael SL, Shaw GM (1999) Maternal corticosteroid use and risk of selected congenital anomalies. Am J Med Genet 86(3):242–244. https://doi.org/10.1002/(sici)1096-8628(19990917)86:3%3c242::aid-ajmg9%3e3.0.co;2-u

Article  CAS  PubMed  Google Scholar 

Carmichael SL, Shaw GM, Ma C, Werler MM, Rasmussen SA, Lammer EJ and Study NBDP (2007) Maternal corticosteroid use and orofacial clefts. Am J Obstet Gynecol 197(6):585-e1. https://doi.org/10.1016/j.ajog.2007.05.046

Article  CAS  Google Scholar 

Carter JD, Ladhani A, Ricca LR, Valeriano J, Vasey FB (2009) A safety assessment of tumor necrosis factor antagonists during pregnancy: a review of the Food and Drug Administration database. J Rheumatol 36(3):635–641. https://doi.org/10.3899/jrheum.080545

Article  PubMed  Google Scholar 

Cassina M, Johnson DL, Robinson LK, Braddock SR, Xu R, Jimenez JL, Mirrasoul N, Salas E, Luo YJ, Jones KL, Chambers CD (2012) Pregnancy outcome in women exposed to leflunomide before or during pregnancy. Arthritis Rheum 64(7):2085–2094. https://doi.org/10.1002/art.34419

Article  CAS  PubMed  Google Scholar 

Chakravarty EF (2011) Rheumatoid arthritis and pregnancy: beyond smaller and preterm babies. Arthritis Rheum 63(6):1469–1471. https://doi.org/10.1002/art.30206

Article  PubMed  Google Scholar 

Chakravarty EF, Nelson L, Krishnan E (2006) Obstetric hospitalizations in the United States for women with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 54(3):899–907. https://doi.org/10.1002/art.21663

Article  PubMed  Google Scholar 

Chakravarty EF, Murray ER, Kelman A, Farmer P (2011) Pregnancy outcomes after maternal exposure to rituximab. Blood J Am Soc Hematol 117(5):1499–1506. https://doi.org/10.1182/blood-2010-07-295444

Article  CAS  Google Scholar 

Chang Z, Spong CY, Jesus AA, Davis MA, Plass N, Stone DL, Chapelle D, Hoffmann P, Kastner DL, Barron K and Goldbach‐Mansky RT (2014) Brief report: anakinra use during pregnancy in patients with cryopyrin‐associated periodic syndromes.https://doi.org/10.1002/art.38811

Cleary BJ, Källén B (2009) Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A 85(7):647–654. https://doi.org/10.1002/bdra.20583

Article  CAS  Google Scholar 

Costedoat-Chalumeau N, Amoura Z, Aymard G, Du Le Thi Hong, DLTH, Wechsler B, Vauthier D, Dermer ME, Darbois Y, Piette JC (2002) Evidence of transplacental passage of hydroxychloroquine in humans

Dawood MY (1993) Non-steroidal anti-inflammatory drugs and reproduction. Am J Obstet Gynecol 169:1255–1265. https://doi.org/10.1002/art.10150

Article  CAS  PubMed  Google Scholar 

Dawson AL, Riehle-Colarusso T, Reefhuis J, Arena JF, National Birth Defects Prevention Study (2014) Maternal exposure to methotrexate and birth defects: a population-based study. Am J Med Genet A 164(9):2212–2216. https://doi.org/10.1002/ajmg.a.36625

Article  CAS  Google Scholar 

De Man YA, Dolhain RJ, Van De Geijn FE, Willemsen SP, Hazes JM (2008) Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Care Res 59(9):1241–1248. https://doi.org/10.1002/art.24003

Article  Google Scholar 

De Man YA, Bakker-Jonges LE, Dufour-Van Den Goorbergh CM, Tillemans SPR, Hooijkaas H, Hazes JMW, Dolhain RJEM (2010) Women with rheumatoid arthritis negative for anti-cyclic citrullinated peptide and rheumatoid factor are more likely to improve during pregnancy, whereas in autoantibody-positive women autoantibody levels are not influenced by pregnancy. Ann Rheum Dis 69(2):420–423

Article  PubMed  Google Scholar 

de Man YA, Hazes JM, van der Heide H, Willemsen SP, de Groot CJ, Steegers EA, Dolhain RJ (2009) Association of higher rheumatoid arthritis disease activity during pregnancy with lower birth weight: results of a national prospective study. Arthritis Rheumatism 60(11):3196–3206. https://doi.org/10.1002/art.24914

Article  PubMed  Google Scholar 

de Steenwinkel FD, Hokken-Koelega AC, de Man YA, de Rijke YB, de Ridder MA, Hazes JM, Dolhain RJ (2013) Circulating maternal cytokines influence fetal growth in pregnant women with rheumatoid arthritis. Ann Rheum Dis 72(12):1995–2001

Article  PubMed  Google Scholar 

de Steenwinkel FD, Hokken-Koelega AC, de Ridder MA, Hazes JM, Dolhain RJ (2014a) Rheumatoid arthritis during pregnancy and postnatal catch-up growth in the offspring. Arthritis Rheumatol 66(7):1705–1711. https://doi.org/10.1002/art.38519

Article  PubMed  Google Scholar 

de Steenwinkel FD, Hokken-Koelega AC, Hazes JM, Dolhain RJ (2014b) The influence of foetal prednisone exposure on the cortisol levels in the offspring. Clin Endocrinol 80(6):804–810. https://doi.org/10.1111/cen.12388

Article  CAS  Google Scholar 

Dedmon LE (2020) The genetics of rheumatoid arthritis. Rheumatology 59(10):2661–2670. https://doi.org/10.1093/rheumatology/keaa232

Article  CAS  PubMed  Google Scholar 

Diav-Citrin O, Shechtman S, Schwartz V, Avgil-Tsadok M, Finkel-Pekarsky V, Wajnberg R, Arnon J, Berkovitch M, Ornoy A (2010) Pregnancy outcome after in utero exposure to colchicine. Am J Obstet Gynecol 203(2):144-e1. https://doi.org/10.1016/j.ajog.2010.02.063

Article  CAS  Google Scholar 

Diav-Citrin O, Blyakhman S, Shechtman S, Ornoy A (2013) Pregnancy outcome following in utero exposure to hydroxychloroquine: a prospective comparative observational study. Reprod Toxicol 39:58–62. https://doi.org/10.1016/j.reprotox.2013.04.005

Article  CAS  PubMed  Google Scholar 

Erez O, Mastrolia SA, Thachil J (2015) Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management. Am J Obstet Gynecol 213(4):452–463. https://doi.org/10.1016/j.ajog.2015.03.054

Article  CAS  PubMed  Google Scholar 

Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M (2006) Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheumatism 54(7):2096–2108. https://doi.org/10.1002/art.21930

Article  CAS  PubMed  Google Scholar 

Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K, Arthanari S, Cunningham J, Flanders L, Moore L, Crossley A (2016) BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding—Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology 55(9):1693–1697. https://doi.org/10.1093/rheumatology/kev404

Article  CAS  PubMed 

Comments (0)

No login
gif