Abdollahi AR, Firouzian F, Haddadi R, Nourian A (2021) Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation. Inflammopharmacology 29(1):107–121. https://doi.org/10.1007/s10787-020-00776-6

Article  CAS  PubMed  Google Scholar 

Afnan A, Saleem A, Akhtar MF (2023) Chrysin, a 5,7-dihydroxyflavone restrains inflammatory arthritis in rats via subsiding oxidative stress biomarkers and inflammatory cytokines. Inflammopharmacology. https://doi.org/10.1007/s10787-023-01229-6

Article  PubMed  Google Scholar 

Akhter S, Muhammad H, Alamgeer I, Jahan S, Shahzad M (2022) Nerolidol : a potential approach in rheumatoid arthritis through reduction of TNF-α, IL-1β, IL-6, NF-kB, COX-2 and antioxidant effect in CFA-induced arthritic model. Inflammopharmacology. https://doi.org/10.1007/s10787-022-00930-2

Article  PubMed  Google Scholar 

Amin A, Akhtar MF, Saleem A, Sharif A, Shah S, Khan MI, Sohail MF (2022) Pterostilbene improves CFA-induced arthritis and peripheral neuropathy through modulation of oxidative stress, inflammatory cytokines and neurotransmitters in Wistar rats. Inflammopharmacology. https://doi.org/10.1007/s10787-022-01069-w

Article  PubMed  Google Scholar 

Asija R, Samaria S, Khanijau R, Verma T (2022) Evaluation of anti-arthritic activity of the ethanolic extract of Catharanthus roseus in Wistar Rats. Chem Res J 7(2):116–127

CAS  Google Scholar 

Baa A, Sakat SS, Joshi K, Paudel S, Joshi D, Joshi K, Varshney A (2019) Anti-inflammatory and anti-arthritic efficacies of an indian traditional herbo-mineral medicine “Divya Amvatari Ras” in collagen antibody: induced arthritis (CAIA) mouse model through modulation of IL-6/IL-1 β/TNF-α/NF κ B signaling. Front Pharmacol 10:1–19. https://doi.org/10.3389/fphar.2019.00659

Article  CAS  Google Scholar 

Bao Y, Sun Y, Ji J, Gan L, Zhang C, Wang C, Yuan C (2019) Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK/STAT and NF-κB signaling pathways Yarigui. Phytomedicine. https://doi.org/10.1016/j.phymed.2019.153036

Article  PubMed  Google Scholar 

Bhal S, Kassam K (2005) Application note structural optimization of leads to improve ADME properties

Calabresi E, Petrelli F, Bonifacio AF, Puxeddu I, Alunno A (2018) Review one year in review 2018: pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol 36(2):175–184

PubMed  Google Scholar 

Caporali R, Fakhouri WKH, Nicolay C, Longley HJ, Losi S, Rogai V (2020) New rheumatoid arthritis treatments for ‘Old’ patients: results of a systematic review. Adv Ther 37(9):3676–3691. https://doi.org/10.1007/s12325-020-01435-6

Article  PubMed  PubMed Central  Google Scholar 

Carolina A, Costa DF, De Sousa LM, Maria J, Goes P, Maria K, Gondim DV (2021) Anti-inflammatory and hepatoprotective effects of quercetin in an experimental model of rheumatoid arthritis. Inflammation 44(5):2033–2043. https://doi.org/10.1007/s10753-021-01479-y

Article  CAS  Google Scholar 

Cellat M, İşler CT, Kutlu T, Kuzu M, Etyemez M, Alakuş H, Güvenç M (2022) Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats. J Biochem Mol Toxicol. https://doi.org/10.1002/jbt.23140

Article  PubMed  Google Scholar 

Chen G, Song Y, Ma F, Ma Y (2020) Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines. Korean J Physiol Pharmacol 24(6):453–462. https://doi.org/10.4196/kjpp.2020.24.6.453

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhary N, Bhatt LK, Prabhavalkar KS (2018) Experimental animal models for rheumatoid arthritis. Immunopharmacol Immunotoxicol. https://doi.org/10.1080/08923973.2018.1434793

Article  PubMed  Google Scholar 

Conigliaro P, Triggianese P, De Martino E, Fonti GL, Chimenti MS, Sunzini F, Perricone R (2019) Challenges in the treatment of rheumatoid arthritis. Autoimmun Rev 18(7):706–713. https://doi.org/10.1016/j.autrev.2019.05.007

Article  PubMed  Google Scholar 

Cui X, Wang R, Bian P, Wu Q, Seshadri VDD, Liu L (2019) Evaluation of antiarthritic activity of nimbolide against Freund’s adjuvant induced arthritis in rats. Artif Cells, Nanomed Biotechnol 47(1):3391–3398. https://doi.org/10.1080/21691401.2019.1649269

Article  CAS  PubMed  Google Scholar 

De S, Kundu S, Chatterjee M (2020) Generation of a robust model for inducing autoimmune arthritis in Sprague Dawley rats. J Pharmacol Toxicol Methods 102:106659. https://doi.org/10.1016/j.vascn.2019.106659

Article  CAS  PubMed  Google Scholar 

Dhikale R, Gulecha V, Zalte A (2022) Amelioration of CFA induced arthritis in rats by buchnania lanzan. Int J Health Sci 6:2459–2484. https://doi.org/10.53730/ijhs.v6ns2.5565

Article  Google Scholar 

Ezeani NN, Ibiam UA, Orji OU, Igwenyi IO, Aloke C, Alum E, Ugwu OPC (2019) Effects of aqueous and ethanol root extracts of olax subscopioidea on inflammatory parameters in complete freund’s adjuvant-collagen type II induced arthritic albino rats. Pharmacogn J 11(1):16–25. https://doi.org/10.5530/pj.2019.1.4

Article  CAS  Google Scholar 

Findeisen KE, Sewell J, Ostor AJK (2021) Biological therapies for rheumatoid arthritis: an overview for the clinician. Biol Targets Ther 15:343–352. https://doi.org/10.2147/BTT.S252575

Article  Google Scholar 

Fraenkel L, Bathon JM, England BR, St. Clair EW, Arayssi T, Carandang K, Akl EA (2021) 2021 American College of rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol 73(7):1108–1123. https://doi.org/10.1002/art.41752

Article  PubMed  Google Scholar 

Gautam RK, Sharma S, Sharma K, Gupta G (2018) Evaluation of antiarthritic activity of butanol fraction of Punica granatum linn. Rind extract against Freund’s complete adjuvant-induced arthritis in rats. J Environ Pathol, Toxicol Oncol 37(1):53–62. https://doi.org/10.1615/JEnvironPatholToxicolOncol.2018025137

Article  PubMed  Google Scholar 

Gautam RK, Gupta G, Sharma S, Hatware K, Patil K, Sharma K, Dua K (2019) Rosmarinic acid attenuates inflammation in experimentally induced arthritis in Wistar rats, using Freund’s complete adjuvant. Int J Rheum Dis 22(7):1247–1254. https://doi.org/10.1111/1756-185X.13602

Article  CAS  PubMed  Google Scholar 

Gautam RK, Sharma S, Sharma K, Goyal S (2020) Evaluation of comparative anti-arthritic activity of traditionally well documented medicinal plants in rats. Indian J Pharm Sci 82(5):781–786. https://doi.org/10.36468/pharmaceutical-sciences.706

Article  CAS  Google Scholar 

Hegde K (2020) Anti arthritic potentials of piper betle: a preclinical study. Indian J Pharm Pharmacol 5(1):21–28. https://doi.org/10.18231/2393-9087.2018.0006

Article  Google Scholar 

Hua D, Yang J, Meng Q, Ling Y, Wei Q, Wang Z, Hu C (2021) Soufeng sanjie formula alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation. Chin Med (UK) 16(1):1–15. https://doi.org/10.1186/s13020-021-00448-9

Article  CAS  Google Scholar 

Hussain A, Aslam B, Muhammad F, Faisal MN, Kousar S, Mushtaq A, Bari MU (2021) Anti-arthritic activity of Ricinus communis L. and Withania somnifera L. extracts in adjuvant-induced arthritic rats via modulating inflammatory mediators and subsiding oxidative stress. Iran J Basic Med Sci 24(7):951–961

PubMed  PubMed Central  Google Scholar 

Javed K, Rakha A, Butt MS, Faisal MN, Tariq U, Saleem M (2022) Evaluating the anti-arthritic potential of walnut (Juglans regia L.) in FCA induced Sprague Dawley rats. J Food Biochem. https://doi.org/10.1111/jfbc.14327

Article  PubMed  Google Scholar 

Jin S, Zhao J, Li M, Zeng X (2022) New insights into the pathogenesis and management of rheumatoid arthritis. Chronic Dis Transl Med. https://doi.org/10.1002/cdt3.43

Article  PubMed  PubMed Central  Google Scholar 

Kundu T, Pramanik A (2020) Expeditious and eco-friendly synthesis of new multifunctionalized pyrrole derivatives and evaluation of their antioxidant property. Bioorg Chem 98:103734. https://doi.org/10.1016/j.bioorg.2020.103734

Article  CAS  PubMed  Google Scholar 

Lu QJ, Li JY, Lin HX, Cai YS, Liu CS, Fu LP, Yuan LX (2022a) Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis. Pharm Biol 60(1):1606–1615. https://doi.org/10.1080/13880209.2022.2107018

Article  PubMed  PubMed Central  Google Scholar 

Lu Q, Jiang H, Zhu Q, Xu J, Cai Y, Huo G, Xu A (2022b) Tetrandrine ameliorates rheumatoid arthritis in mice by alleviating neutrophil activities. Evid-Based Complement Altern Med. https://doi.org/10.1155/2022/8589121

Article  Google Scholar 

Manan M, Saleem U, Hamid Akash MS, Qasim M, Hayat M, Raza Z, Ahmad B (2020) Antiarthritic potential of comprehensively standardized extract of Alternanthera bettzickiana: in vitro and in vivo studies. ACS Omega 5(31):19478–19496. https://doi.org/10.1021/acsomega.0c01670

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng M, Yue Z, Chang L, Liu Y, Hu J, Song Z, Wang C (2021) Anti-rheumatoid arthritic effects of paris saponin VII in human rheumatoid arthritis fibroblast-like synoviocytes and adjuvant-induced arthritis in rats. Front Pharmacol 12:1–20. https://doi.org/10.3389/fphar.2021.683698

Article  CAS  Google Scholar 

Miao Y, Yang J, Yun Y, Sun J, Wang X (2021) Synthesis and anti-rheumatoid arthritis activities of 3- (4-aminophenyl)-coumarin derivatives. J Enzyme Inhib Med Chem 36(1):450–461. https://doi.org/10.1080/14756366.2021.1873978

Article  CAS  PubMed  PubMed Central  Google Scholar 

OECD (2002) OECD guidelines for the testing of chemicals. Test no. 423: acute oral toxicity—acute toxic class method. OECD Guidel Test Chem. https://doi.org/10.1787/9789264071001-en

Article  Google Scholar 

Prajapati P, Gajera V (2022) Anti-arthritic effect of methanol extract of leaves of Abies webbiana Lindl. in complete Freund’s adjuvant-induced arthritis in albino rats. Int J Health Sci 6:7400–7417. https://doi.org/10.53730/ijhs.v6ns1.6591