Crucian B, Babiak-Vazquez A, Johnston S, Pierson D, Ott CM, Sams C. Incidence of clinical symptoms during long-duration orbital spaceflight. Int J Gen Med. 2016;9:383–91.
Article PubMed PubMed Central Google Scholar
Spielmann G, Agha N, Kunz H, Simpson RJ, Crucian B, Mehta S, et al. B cell homeostasis is maintained during long-duration spaceflight. J Appl Physiol. 2019;126:469–76.
Article CAS PubMed Google Scholar
Bonnefoy J, Baselet B, Moser D, Ghislin S, Miranda S, Riant E, et al. B-cell homeostasis is maintained during two months of Head-down tilt bed rest with or without antioxidant supplementation. Front Immunol. 2022;13:830662.
Article CAS PubMed PubMed Central Google Scholar
Buchheim J, Ghislin S, Ouzren N, Albuisson E, Vanet A, Matzel S, et al. Plasticity of the human IgM repertoire in response to long-term spaceflight. FASEB J. 2020;34:16144–62.
Article CAS PubMed Google Scholar
Rettig TA, Tan JC, Nishiyama NC, Chapes SK, Pecaut MJ. An analysis of the effects of spaceflight and vaccination on antibody repertoire diversity. Immunohorizons. 2021;5:675–86.
Article CAS PubMed Google Scholar
Globus RK, Morey-Holton E. Hindlimb unloading: rodent analog for microgravity. J Appl Physiol. 2016;120:1196–206.
Article CAS PubMed Google Scholar
Rettig TA, Nishiyama NC, Pecaut MJ, Chapes SK. Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. Life Sci Space Res. 2019;22:16–28.
Rettig TA, Bye BA, Nishiyama NC, Hlavacek S, Ward C, Pecaut MJ, et al. Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. PLoS One. 2019;14:e0210284.
Article CAS PubMed PubMed Central Google Scholar
Boxio R, Dournon C, Frippiat J-P. Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl. J Appl Physiol. 2005;98:905–10.
Article CAS PubMed Google Scholar
Bascove M, Huin-Schohn C, Guéguinou N, Tschirhart E, Frippiat J-P. Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl. FASEB J. 2009;23:1607–15.
Article CAS PubMed Google Scholar
Frippiat J-P. Contribution of the urodele amphibian Pleurodeles waltl to the analysis of spaceflight-associated immune system deregulation. Mol Immunol. 2013;56:434–41.
Article CAS PubMed Google Scholar
Bascove M, Guéguinou N, Schaerlinger B, Gauquelin-Koch G, Frippiat J-P. Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions. FASEB J. 2011;25:2947–55.
Article CAS PubMed Google Scholar
Schatz DG, Swanson PC. V(D)J recombination: mechanisms of initiation. Annu Rev Genet. 2011;45:167–202.
Article CAS PubMed Google Scholar
Ma Y, Pannicke U, Schwarz K, Lieber MR. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 2002;108:781–94.
Article CAS PubMed Google Scholar
Huin-Schohn C, Guéguinou N, Schenten V, Bascove M, Koch GG, Baatout S, et al. Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. FASEB J. 2013;27:333–41.
Article CAS PubMed Google Scholar
Lescale C, Schenten V, Djeghloul D, Bennabi M, Gaignier F, Vandamme K, et al. Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging. FASEB J. 2015;29:455–63.
Article CAS PubMed Google Scholar
Tascher G, Gerbaix M, Maes P, Chazarin B, Ghislin S, Antropova E, et al. Analysis of femurs from mice embarked on board BION-M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on earth. FASEB J. 2019;33:3772–83.
Article CAS PubMed Google Scholar
Lescale C, Dias S, Maës J, Cumano A, Szabo P, Charron D, et al. Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age. Aging Cell. 2010;9:410–9.
Article CAS PubMed Google Scholar
Pulivarthy SR, Lion M, Kuzu G, Matthews AGW, Borowsky ML, Morris J, et al. Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination. Proc Natl Acad Sci U S A. 2016;113:E6427–36.
Article CAS PubMed PubMed Central Google Scholar
Baizan-Edge A, Stubbs BA, Stubbington MJT, Bolland DJ, Tabbada K, Andrews S, et al. IL-7R signaling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells. Cell Rep. 2021;36:109349.
Article CAS PubMed PubMed Central Google Scholar
Taves MD, Hamden JE, Soma KK. Local glucocorticoid production in lymphoid organs of mice and birds: functions in lymphocyte development. Horm Behav. 2017;88:4–14.
Article CAS PubMed Google Scholar
Gaignier F, Schenten V, De Carvalho BM, Gauquelin-Koch G, Frippiat J-P, Legrand-Frossi C. Three weeks of murine Hindlimb unloading induces shifts from B to T and from Th to Tc splenic lymphocytes in absence of stress and differentially reduces cell-specific Mitogenic responses. PLoS One. 2014;9:e92664.
Article PubMed PubMed Central Google Scholar
The International Immunogenetics Information System: IMGT. https://www.imgt.org/. Accessed 05 June 2023.
Rettig TA, Ward C, Pecaut MJ, Chapes SK. Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the international Space Station. Gravit Space Res. 2017;5:2–23.
Article PubMed PubMed Central Google Scholar
Rettig TA, Ward C, Bye BA, Pecaut MJ, Chapes SK. Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing. PLoS One. 2018;13:e0190982.
Article PubMed PubMed Central Google Scholar
Johnston CM, Wood AL, Bolland DJ, Corcoran AE. Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain V region. J Immunol. 2006;176:4221–34.
Article CAS PubMed Google Scholar
Dong Y, Wu C, Zhao X, Zhang P, Zhang H, Zheng M, et al. Epigenetic modifications of the V H region after DJ H recombination in pro-B cells. Immunology. 2017;152:218–31.
Article CAS PubMed PubMed Central Google Scholar
Gong M, Li X, Zheng A, Xu H, Xie S, Yan R, et al. Age-related changes in the TRB and IGH repertoires in healthy adult males and females. Immunol Lett. 2021;240:71–6.
Article CAS PubMed Google Scholar
Lucas JS, Murre C, Feeney AJ, Riblet R. The structure and regulation of the immunoglobulin loci. In: Alt FW, Honjo T, Radbruch A, Reth M, editors. Molecular biology of B cells. Elsevier; 2015. p. 1–11.
PubMed. https://pubmed.ncbi.nlm.nih.gov/. Accessed 05 June 2023.
The NCBI Sequence Read Archive. https://www.ncbi.nlm.nih.gov/sra. Accessed 05 June 2023.
Ward C, Rettig TA, Hlavacek S, Bye BA, Pecaut MJ, Chapes SK. Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice. Life Sci Space Res. 2018;16:63–75.
Guerrettaz LM, Johnson SA, Cambier JC. Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci U S A. 2008;105:11898–902.
Article CAS PubMed PubMed Central Google Scholar
De Bourcy CFA, Angel CJL, Vollmers C, Dekker CL, Davis MM, Quake SR. Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging. Proc Natl Acad Sci U S A. 2017;114:1105–10.
Article PubMed PubMed Central Google Scholar
Jiang N, He J, Weinstein JA, Penland L, Sasaki S, He X-S, et al. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013;5:171ra19.
Article PubMed PubMed Central Google Scholar
Wang C, Liu Y, Xu LT, Jackson KJL, Roskin KM, Pham TD, et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J Immunol. 2014;192:603–11.
Article CAS PubMed Google Scholar
Jensen K, Rother MB, Brusletto BS, Olstad OK, Dalsbotten Aass HC, Van Zelm MC, et al. Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output. J Immunol. 2013;191:1210–9.
Article CAS PubMed Google Scholar
Labrie JE, Borghesi L, Gerstein RM. Bone marrow microenvironmental changes in aged mice compromise V(D)J recombinase activity and B cell generation. Semin Immunol. 2005;17:347–55.
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